Effect of Tether Length on endo/exo Stereoselectivity in Alkene–Arene meta‐Photocycloaddition Reactions towards the Aphidocolin/Stemodin Scaffolds
Aljazy A. A. Alshammari,
Joseph W. Boyd,
Nicola Greaves
et al.
Abstract:Intramolecular alkene‐arene meta‐photocycloadditions are powerful transformations that use the enhanced reactivity of photoexcited benzene rings to facilitate addition of an alkene 1,3 across donor groups and form complex three‐dimensional fused‐ring systems from readily accessible starting materials. Intramolecular examples have traditionally been restricted to 3‐membered tethers, with cycloaddition resulting from exo‐conformation. However, by judicious tether design we have demonstrated that a 4‐membered tet… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.