Effect of Testosterone Propionate and Methyl Testosterone on Growth and Skeletal Maturation in Rats

Joss, E; Zuppinger, K; Sobel, Edna H.

doi:10.1210/endo-72-1-123

Cited by 27 publications

(2 citation statements)

References 18 publications

(26 reference statements)

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“…For in all three of the papers, the authors did not relate measurements of phys iologically active levels of testosterone to cognitive per formance, but rather used supposed androgen indicators (various head and body measurements along with hair characteristics and muscle development; 17-ketosteroid excretions were only used by Klaiber et al (1967]). Thus, the androgen levels were estimated using variables, all of which -as cited in the above-mentioned works -had been conjectured by Dorfman and Shipley [1956], Tan ner et al [1959], Tanner [1962], Joss et al [1963], Tan ner [ 1969], and Rosenfield [ 1971 ] to be related to andro gens. Newer studies [summarized in Bardin and Catterall, 1981;Vague, 1983; in which serum hormone deter minations have been carried out using radioimmunoas says and in which some determinations of free testoster one in the saliva have also been made have shown that all the relationships between testosterone and physique conjectured earlier either are not in the direction ex pected or are not to T^ at all, but rather to DHT, free testosterone, or to the interrelationships between the hormones.…”

Section: Discussionmentioning

confidence: 99%

Sex Hormones and Cognitive Functioning in Men

1987

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Blood and saliva samples were obtained from 117 healthy young men, following which radioimmunoassays were used to determine the serum concentrations of testosterone (T_ser), 5α-dihydrotestosterone (DHT), and the level of free testosterone (T_sal) in the saliva. The cognitive functioning was determined by five spatial and six verbal ipsative test scores, reflecting intra-individual variance in the performance of these tasks, independent of the person’s general level of achievement. Within the normal physiological range androgen levels – especially T_ser and to a lesser extent DHT and T_sal – showed a significantly positive correlation with measures of spatial ability and field dependence-independence and a significantly negative correlation with measures of verbal production.

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Section: Discussionmentioning

confidence: 99%

Sex Hormones and Cognitive Functioning in Men

1987

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“…•*• growing mice (Silberberg & Silberberg, 1956, 1961Howard, 1963) rats (Joss, Zuppinger, & Sobel, 1963;Ronning, Makinen, Lathimer, & Raijola, 1964), and children (Geller, 1964) advanced skeletal maturation. These compounds also accelerated the articular aging changes which may be considered as pacemakers for the evolution of senile osteoarthrosis (Weichselbaum, 1877;Silberberg & Silberberg, 1941, 1961aBennett, Waine, & Bauer, 1942;de Palma, 1957;Papadia, Montinari, & Cagnazzo, 1959).…”

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confidence: 99%