“…Patients with hypercalcemia and breast cancer usually have widespread osteolytic bone secondaries (Galasko & Burn 1971) associated with release of calcium from the skeleton in excess of that which can be cleared by the kidney (Laszlo et al 1952). This idea is supported by the data of Coombes, who has shown how patients with breast cancer and bone metastases have reduced calcium absorption from the gut (Coombes, Ward, Greenberg et al 1976).…”