Effect of testosterone on bone density and bone metabolism in adolescent male hypogonadism

Arisaka, Osamu; Arisaka, Madoka; Nakayama, Yuko; Fujiwara, Sachi; Yabuta, Keijiro

doi:10.1016/0026-0495(95)90046-2

Cited by 64 publications

(35 citation statements)

References 23 publications

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“…Bone is considered a target tissue for androgens [1]: hypogonadal men showed reduced bone mineral density (BMD) [2, 3], and androgen administration improved BMD in both osteopenic men and women [3, 4, 5, 6]. Androgen receptors have been identified in normal human osteoblast-like cells [7], and androgens stimulate osteoblast proliferation and differentiation [8]and may inhibit bone resorption [9].…”

Section: Introductionmentioning

confidence: 99%

Altered Bone Mineral Density in Patients with Complete Androgen Insensitivity Syndrome

et al. 1998

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Androgens have major influences on the regulation of bone mineralization. Because of their unique peripheral metabolism androgens may act on bone via activation of the androgen and/or estrogen receptor. Patients with complete androgen insensitivity syndrome (cAIS) are natural models to assess androgen actions on bone. We studied bone mineral density (BMD) in 10 patients with cAIS (mean age 13.70, range 4.7–19.8 years); 3 patients were studied before gonadectomy; the others were castrated and 6 were on hormonal replacement therapy. The BMD area (aBMD) was measured by dual energy X-ray; lumbar ‘apparent’ volumetric density (vBMD) was calculated using the formula vBMD = aBMD × [4/(π × width)]. In the patients, aBMD (0.72 ± 0.16 g/cm²) and vBMD (0.23 ± 0.04 g/cm³) were significantly (p < 0.001) reduced in comparison with those of a control group (n = 15, age 5.0–20.5 years: aBMD 1.028 ± 0.20 g/cm²; vBMD 0.35 ± 0.04 g/cm³). Both aBMD and vBMD were also reduced in comparison with normal values for males (aBMD –2.66 ± 0.99 SDS, p < 0.001; vBMD –3.08 ± 1.53 SDS, p < 0.0005) and females (aBMD –2.88 ± 1.05 SDS, p < 0.001; vBMD –2.84 ± 1.18 SDS, p < 0.0007). Real lumbar bone density, assessed by computed tomography in 1 patient, was also reduced (–6.2 SDS and –3.5 SDS for male and female normal values, respectively). Biochemical markers of bone metabolism were normal and not significantly different in patients and controls. Girls with cAIS did not have more fractures than controls. In conclusion, both aBMD and vBMD are reduced in cAIS patients, while bone turnover and the fracture risk seem not to be increased. Our data indicate that both androgens and estrogens may be required for acquisition of bone density during childhood.

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Section: Introductionmentioning

confidence: 99%

Altered Bone Mineral Density in Patients with Complete Androgen Insensitivity Syndrome

et al. 1998

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“…An elevated IGF-I level suggests enhancement of the growth hormone-IGF-I axis and an elevated osteocalcin level may reflect accelerated bone maturation due to excessive levels of the sex steroid E2. In fact, excess levels of androgenic sex steroids in infants with congenital adrenal hyperplasia are known to be associated with increased serum osteocalcin levels and bone maturation and androgens have been demonstrated to exert direct effects on bone (18,19).…”

Section: Growth and Skeletal Maturationmentioning

confidence: 99%

Effect of Neonatal Ovarian Cysts on Infant Growth

Arisaka

Hosaka

Shimura

et al. 1995

Clin Pediatr Endocrinol

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Ovarian follicular cysts were diagnosed antenatally or postnatally by routine obstetric ultrasound scanning in 7 infants. In 5 of them the serum levels of estradiol (E2), insulin-like growth factor-I (IGF-I), osteocalcin and other hormones were measured serially after birth for almost one year. The patients' growth and skeletal maturation were also assessed. The elevated serum E2 levels (242-8,300 pg/mL) in cases with ovarian cysts fell after cystectomy/cyst aspiration or conservative management, but their serum E2 levels remained high compared with those of control infants for 1-5 months. The IGF-I and osteocalcin serum levels of some patients were also relatively high.Furthermore, a tendency to growth acceleration during early infancy and advancement of skeletal age were each observed in two patients.Our present observations suggest that neonatal ovarian cysts associated with elevated serum E2 levels during early infancy may affect the statural growth and bone maturation of female infants.

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“…Hypogonadism is accompanied by low bone mineral density (BMD) (1), and testosterone (T) replacement therapy resulted in a steady increase in BMD in hypogonadal adolescent boys and adult men (2)(3)(4)(5). Several markers of bone turnover have been utilized to investigate the mechanisms for increased BMD by T treatment; these suggest that reduced bone resorption is considerable in adults (3,4) and is largely due to the effects of estrogens converted from T (6).…”

Section: Introductionmentioning

confidence: 99%

Testosterone-Induced Changes in Markers of Bone Turnover in Adolescent Boys with Testicular Dysfunction

Ogawa

Katsushima

Fujiwara

et al. 2003

Clin Pediatr Endocrinol

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Abstract. The effects of testosterone (T) for pubertal induction on bone mineral density (BMD) and biochemical markers of bone turnover were evaluated in three boys with testicular dysfunction. Testosterone enanthate (50 mg) was administered every 4 weeks for 1 year intramuscularly in all subjects. BMD and markers of bone turnover including serum osteocalcin, bone-specific alkaline phosphatase (bALP), urinary deoxypyridinoline (Dpyr), and N-terminal telopeptide of type I collagen, were measured before and during T treatment. BMD steadily increased during treatment. All markers of bone turnover were increased at 6 months of treatment, although increases were statistically significant only in bALP and Dpyr. An initial increase in markers of bone turnover has not been described in adults, but the observed changes resemble spontaneous puberty. The effects of exogenous T administration on bone turnover appear to differ depending on age.

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Effect of testosterone on bone density and bone metabolism in adolescent male hypogonadism

Cited by 64 publications

References 23 publications

Altered Bone Mineral Density in Patients with Complete Androgen Insensitivity Syndrome

Altered Bone Mineral Density in Patients with Complete Androgen Insensitivity Syndrome

Effect of Neonatal Ovarian Cysts on Infant Growth

Testosterone-Induced Changes in Markers of Bone Turnover in Adolescent Boys with Testicular Dysfunction

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