Effect of Testosterone Administration on Liver Fat in Older Men With Mobility Limitation: Results From a Randomized Controlled Trial

Abstract

Testosterone administration in older men with mobility limitation and low testosterone levels was not associated with a reduction in hepatic fat. Larger trials are needed to determine whether testosterone replacement improves liver fat in men with nonalcoholic hepatic steatosis.

MR spectroscopy of hepatic fat and adiponectin and leptin levels during testosterone therapy in type 2 diabetes: a randomized, double-blinded, placebo-controlled trial

“…There is evidence that TRT may reduce ectopic fat deposition and improve the adipokine profile in ageing men with and without T2D (30,31,32,33,34,35,36) possibly through the inhibition of the adipogenic lineage (37,38). A beneficial effect on ectopic fat deposition is consistent with reports showing that TRT increases lipid oxidation in hypopituitary men (39,40) and in ageing men without T2D (41), but could also simply reflect an overall effect of TRT on total fat mass (35,41,42).…”

“…One previous study has evaluated the efficacy of TRT on the content of hepatic fat in ageing men with T2D (30) and the sparse reports on the content of hepatic fat in men without T2D during TRT are conflicting probably due to different assessment methods, inhomogeneous groups of included patients e.g. large age spans and varying biochemical cutoffs for hypogonadism (32,33,34,36). In theory, a reduction of SAT may result in a beneficial change in the adipokine profile with an increase in adiponectin levels and a decrease in leptin concentrations (43,44).…”

Low testosterone and non-alcoholic fatty liver disease: Evidence for their independent association in men with chronic spinal cord injury

“…Although ultrasonography is the diagnostic tool of choice for NAFLD, because it is non-invasive, safe, sensitive, and specific in identifying fatty infiltration, 34 liver biopsy is regarded as the gold standard for detecting hepatic steatosis. 39 reported that testosterone administration for 6 months was not associated with a reduction in hepatic fat in older men with mobility limitation and low testosterone levels. Differences in the characteristics of study populations and in diagnosis methods could partially explain these conflicting results.…”

Low serum sex hormone‐binding globulin is associated with nonalcoholic fatty liver disease in type 2 diabetic patients

“…conducted a testosterone therapy study to supplement testosterone to men with low testosterone and found that fatty liver is alleviated by administration of testosterone for 18 weeks. However, the same beneficial effect is not reproduced in another testosterone therapy study in old man . Thus, aetiological role of testosterone in fatty liver remains to be further elucidated.…”

“…In addition, in a randomized, placebo controlled trial of obese men, testosterone therapy appears to be effective in reducing liver fat . But the result is not reproduced in a study afterwards that administration of testosterone does not alleviate fatty liver in older men . Interestingly, in a case–control study, Goto et al .…”