Effect of tertiary amines on yellowing of UV‐curable epoxide resins

Chiang, Tzu Hsuan; Hsieh, Tsung−Eong

doi:10.1002/pi.2300

Cited by 5 publications

(2 citation statements)

References 23 publications

(27 reference statements)

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“…Though LAP is known to exhibit low yellowing, 67 the yellow discoloration is probably due to the formation of chromophores such as hydroperoxide. 68 We noticed that photo yellowing was reversible, and a few hours after UV exposure or soaking in water, the samples were colorless.…”

Section: ■ Results and Discussionmentioning

confidence: 94%

Mass Spectrometry, Structural Analysis, and Anti-Inflammatory Properties of Photo-Cross-Linked Human Albumin Hydrogels

Sharifi

Saei

Gharibi

et al. 2022

ACS Appl. Bio Mater.

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Albumin-based hydrogels offer unique benefits such as biodegradability and high binding affinity to various biomolecules, which make them suitable candidates for biomedical applications. Here, we report a non-immunogenic photocurable human serumbased (HSA) hydrogel synthesized by methacryloylation of human serum albumin by methacrylic anhydride (MAA). We used matrix-assisted laser desorption ionization-time-offlight mass spectrometry, liquid chromatography-tandem mass spectrometry, as well as size exclusion chromatography to evaluate the extent of modification, hydrolytic and enzymatic degradation of methacrylated albumin macromer and its cross-linked hydrogels. The impacts of methacryloylation and cross-linking on alteration of inflammatory response and toxicity were evaluated in vitro using brain-derived HMC3 macrophages and Ex-Ovo chick chorioallantoic membrane assay. Results revealed that the lysines in HSA were the primary targets reacting with MAA, though modification of cysteine, threonine, serine, and tyrosine, with MAA was also confirmed. Both methacrylated HSA and its derived hydrogels were nontoxic and did not induce inflammatory pathways, while significantly reducing macrophage adhesion to the hydrogels; one of the key steps in the process of foreign body reaction to biomaterials. Cytokine and growth factor analysis showed that albumin-based hydrogels demonstrated anti-inflammatory response modulating cellular events in HMC3 macrophages. Ex-Ovo results also confirmed the biocompatibility of HSA macromer and hydrogels along with slight angiogenesismodulating effects. Photocurable albumin hydrogels may be used as a non-immunogenic platform for various biomedical applications including passivation coatings.

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Section: ■ Results and Discussionmentioning

confidence: 94%

Mass Spectrometry, Structural Analysis, and Anti-Inflammatory Properties of Photo-Cross-Linked Human Albumin Hydrogels

Sharifi

Saei

Gharibi

et al. 2022

ACS Appl. Bio Mater.

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“…Unfortunately, the cured film turns yellow at the light intensity of 13 mW cm −2 as shown in Figure . Because the thermos‐effect of high light intensity accelerates the reaction of the free radicals with functional groups other than double bonds in UV‐curing procedure some chromogenic groups are formed . In the following experiments, the light intensity is set as 0.66 mW cm −2 .…”

Section: Resultsmentioning

confidence: 99%

UV‐curing behavior of unsaturated cyclohexanone formaldehyde resins with thiols

Chang

et al. 2019

J of Applied Polymer Sci

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Numerous researches about the modification and application of cyclohexanone formaldehyde resins (CFR) have been conducted, few of them involve in the UV-curing of unsaturated CFR with thiols. Thus, CFR are synthesized using the rehydrated magnesium-aluminum hydrotalcite as the catalyst and double bonds are introduced by capping the chain ends with 5-norbornene-2,3-dicarboxylic anhydride. Through monitoring the conversion of double bonds with FTIR, the UV-curing behavior of unsaturated CFR in the presence of pentaerythritol tetra (3-mercaptopropionate) is studied. The results show that the conversion of double bonds can reach to 64.1% at 0.66 mW cm −2 of UV light intensity when the molar ratio of double bonds to sulfhydryl groups is 1:1 in the presence of benzoin dimethyl ether (1% of molar amount of double bonds). Considering the similarity between UV-curing of thiols-double bonds and thermo-curing of amine-epoxy, one diffusion controlled kinetics model is derived and it shows good fitness.

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