Effect of temporal lobe structure volume on memory in elderly depressed patients

Ávila, Renata; Ribeiz, Salma Rose Imanari; Duran, Fábio L.S.; Arrais, Jony; Moscoso, Marco Antônio; Bezerra, Diana M.; Jaluul, Omar; Castro, Cláudio Campi de; Busatto, Geraldo F.; Bottino, Cássio M. C.

doi:10.1016/j.neurobiolaging.2009.11.004

Cited by 22 publications

(16 citation statements)

References 30 publications

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“…In this study, we extended this previous result to the structural abnormalities of the other medial temporal and posterior parietal structures, which might be a distinctive feature of LOD as compared with early-onset elderly depression. A previous VBM study by Avila et al (2011) suggesting direct correlation between delayed visual-verbal memory recall scores with left parahippocampal volumes in elderly depressed individuals provided support to the view that depression in elderly populations may be a risk factor for dementia. As our results showed that depression severity was not correlated with the medial temporal and posterior parietal structures, these cognitive impairments might be an independent and co-occurring process in LOD (Butters et al, 2008b).…”

Section: Clinical Implications Of Cognitive Impairments In Lodmentioning

confidence: 68%

Regional Cortical Thickness and Subcortical Volume Changes Are Associated with Cognitive Impairments in the Drug-Naive Patients with Late-Onset Depression

Lim

Jung

Ahn

et al. 2011

Neuropsychopharmacol

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Previous studies have shown an association between late-onset depression (LOD) and cognitive impairment in older adults. However, the neural correlates of this relationship are not yet clear. The aim of this study was to investigate the differences in both cortical thickness and subcortical volumes between drug-naive LOD patients and healthy controls and explore the relationship between LOD and cognitive impairments. A total of 48 elderly, drug-naive patients with LOD and 47 group-matched healthy control subjects underwent 3T MRI scanning, and the cortical thickness was compared between the groups in multiple locations, across the continuous cortical surface. The subcortical volumes were also compared on a structure-by-structure basis. Subjects with LOD exhibited significantly decreased cortical thickness in the rostral anterior cingulate cortex, the medial orbitofrontal cortex, dorsolateral prefrontal cortex, the superior and middle temporal cortex, and the posterior cingulate cortex when compared with healthy subjects (all p<0.05, false discovery rate corrected). Reduced volumes of the right hippocampus was also observed in LOD patients when compared with healthy controls (p<0.001). There were significant correlations between memory functions and cortical thickness of medial temporal, isthmus cingulate, and precuneus (p<0.001). This study was the first study to explore the relationships between the cortical thickness/subcortical volumes and cognitive impairments of drug-naive patients with LOD. These structural changes might explain the neurobiological mechanism of LOD as a risk factor of dementia.

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Section: Clinical Implications Of Cognitive Impairments In Lodmentioning

confidence: 68%

Regional Cortical Thickness and Subcortical Volume Changes Are Associated with Cognitive Impairments in the Drug-Naive Patients with Late-Onset Depression

Lim

Jung

Ahn

et al. 2011

Neuropsychopharmacol

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“…Consistent with the present SMMSE findings, correlations between immediate and delayed free recalls were found with the GM volume of the left hippocampus in a smaller sample of 18 participants with MCI, 21 with AD and 11 CHI [ 13 ]. Additionally, correlations were reported between the MMSE score and the total GM volume [ 13 ], as well as the GM subvolumes of various brain regions including the parietal GM [ 13 ], the frontal GM [ 13 ], and the parahippocampal [ 12 ] and hippocampal subvolumes [ 11 , 12 ]. Of note, and consistent with our findings, the latter correlation was not mediated by the diagnostic category (i.e., MCI, AD, or CHI) [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

Anatomic Correlation of the Mini-Mental State Examination: A Voxel-Based Morphometric Study in Older Adults

Dinomais¹,

Celle²,

Duval³

et al. 2016

PLoS ONE

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The clinical utility of the Mini-Mental State Examination (MMSE) and its shorter version (SMMSE) is still debated. There is a need to better understand the neuroanatomical correlates of these cognitive tests. The objective of this cross-sectional study was to determine whether lower MMSE and SMMSE scores correlated with focal brain volume reduction in older adults. Participants from the GAIT study (n = 207; mean, 70.9±5.9 years; 57% female; mean MMSE 26.2±3.9; mean SMMSE 5.1±1.1) were evaluated using the MMSE and SMMSE and received a 1.5-Tesla MRI scan of the brain. Cortical gray and white matter subvolumes were automatically segmented using Statistical Parametric Mapping. Age, gender, education level, and total intracranial volume were included as potential confounders. We found correlations between the MMSE score and specific cortical regions of the limbic system including the hippocampus, amygdala, cingulate gyrus, and parahippocampal gyrus, independently of the diagnostic category (i.e., mild cognitive impairment or Alzheimer disease or controls). Regarding correlations with the SMMSE score, only one cluster in the left hippocampus was identified, which overlapped with the cluster that was positively correlated with the MMSE score. There were no correlations with the volume of white matter. In conclusion, worse MMSE and SMMSE scores were associated with gray matter atrophy mainly in the limbic system. This finding highlights that atrophy of specific brain regions are related to performance on the MMSE and the SMMSE tests, and provides new insights into the cognitive function probed by these tests.

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“…Treatment with antidepressants significantly improved memory and depression but did not alter hippocampal volume, suggesting that antidepressants may improve hippocampal function in the absence of detectable structural changes (85). Similarly, hippocampal and parahippocampal gyrus volumes do not differentiate between elderly patients with mild to moderate depressive disorders and those without depression (106). This suggests that mechanisms other than hippocampal volume reductions are associated with cognitive and especially memory deficits in elderly depressed patients.…”

Section: Human Hippocampus and Mdd: Does Hippocampal Size Matter?mentioning

confidence: 99%

“…Avila et al. (106) speculate, ‘Future MRI studies involving larger samples, and taking into consideration genetic markers, clinical comorbidities and the age of the depressive symptoms onset, will likely shed further light on the pathophysiology of depression and its associated cognitive deficits in the elderly, as well as on the relationship between this clinical condition and Alzheimer’s Disease’.…”

Section: Human Hippocampus and Mdd: Does Hippocampal Size Matter?mentioning

confidence: 99%

Stress Controversies: Post-Traumatic Stress Disorder, Hippocampal Volume, Gastroduodenal Ulceration*

Fink

2011

Journal of Neuroendocrinology

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IntroductionThe neurobiological response to stress in mammals involves three key mechanisms (1-9). First, the stress is perceived and processed by higher brain centres. Second, the brain mounts a neuroendocrine stress response by way of the hypothalamic-pituitary-adrenal axis (HPA) and the autonomic nervous system (ANS). These two systems trigger behavioural, cardiovascular, endocrine and metabolic cascades that enable the individual to fight, flee and ⁄ or cope with the stress. Third, except in the case of extreme stress, feedback mechanisms restore homeostasis within the HPA and ANS.A major breakthrough in our understanding of the HPA response to stress came from the characterisation by Vale et al. (10) of corticotrophin-releasing factor (CRF), a 41-amino acid residue peptide that mediates neural control of adrenocorticotrophin (ACTH) release from pituitary corticotrophs. A series of physiological studies, including measurements of neurohormone release into hypophysial portal blood in vivo, have confirmed earlier views that arginine vasopressin (AVP) acts synergistically with CRF to control ACTH release (11,12). The actions of CRF and AVP on pituitary corticotrophs are mediated by way of the CRF receptor-1 (CRFR1) and the vasopressin receptor 1B (V1B also termed V3), respectively (13)(14)(15). In addition to its neurohumoral actions, CRF is considered to play a role in mediating stress-induced anxiety, and possibly depressed mood (13)(14)(15)(16)(17)(18)(19)(20). The urocortins, members of the CRF peptide family, have recently been shown to exert metabolic effects (21).Stressful life events can induce depression. The precise mechanisms involved remain to be determined, although genomic data Stress in mammals triggers a neuroendocrine response mediated by the hypothalamic-pituitaryadrenal axis and the autonomic nervous system. Increased activity of these two systems induces behavioural, cardiovascular, endocrine and metabolic cascades that enable the individual to fight or flee and cope with the stress. Our understanding of stress and stress-response mechanisms is generally robust. Here, however, we review three themes that remain controversial and perhaps deserve further scrutiny and investigation before they achieve canonical status. The themes are, first, hypocortisolaemia in post-traumatic stress disorder (PTSD). A reduction rather than a stress-induced increase in adrenal glucocorticoid levels, as seen in major depressive disorder (MDD), is puzzling and furthermore is not a consistent feature of PTSD. Overall, studies on PTSD show that glucocorticoid levels may be normal or higher or lower than normal. The second theme concerns the reduction in volume of the hippocampus in MDD attributed to the neurotoxicity of hypercortisolaemia. Again, as for hypocortisolaemia in PTSD, reduced hippocampal volume in MDD has been found in some but not all studies. Third, the discovery of a causal association between Helicobacter pylori and peptic ulcers apparently brought to an end the long-held view that peptic ulceratio...

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Effect of temporal lobe structure volume on memory in elderly depressed patients

Cited by 22 publications

References 30 publications

Regional Cortical Thickness and Subcortical Volume Changes Are Associated with Cognitive Impairments in the Drug-Naive Patients with Late-Onset Depression

Regional Cortical Thickness and Subcortical Volume Changes Are Associated with Cognitive Impairments in the Drug-Naive Patients with Late-Onset Depression

Anatomic Correlation of the Mini-Mental State Examination: A Voxel-Based Morphometric Study in Older Adults

Stress Controversies: Post-Traumatic Stress Disorder, Hippocampal Volume, Gastroduodenal Ulceration*

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