Effect of temperature on the association behavior in aqueous mixtures of an oppositely charged amphiphilic block copolymer and bile salt

Du, Guanqun; Giudice, Alessandra Del; Alfredsson, Viveka; Carnerup, Anna M.; Pavel, Nicolae Viorel; Loh, Watson; Masci, Giancarlo; Nyström, Bo; Galantini, Luciano; Schillén, Karin

doi:10.1016/j.polymer.2020.122871

Cited by 10 publications

(7 citation statements)

References 96 publications

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“…Indeed, the co‐assembled structures were stable in solution at room temperature for a surprisingly long time (at least for several months). At elevated temperatures above the phase transition of PNIPAM, which is thermoresponsive, the colloidal stability decreases as found for a similar block copolymer–NaDC system [11] …”

Section: Resultsmentioning

confidence: 56%

Condensed Supramolecular Helices: The Twisted Sisters of DNA

Belić

Giudice

et al. 2021

Angewandte Chemie

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Condensation of DNA helices into hexagonally packed bundles and toroids represents an intriguing example of functional organization of biological macromolecules at the nanoscale. The condensation models are based on the unique polyelectrolyte features of DNA, however here we could reproduce a DNA‐like condensation with supramolecular helices of small chiral molecules, thereby demonstrating that it is a more general phenomenon. We show that the bile salt sodium deoxycholate can form supramolecular helices upon interaction with oppositely charged polyelectrolytes of homopolymer or block copolymers. At higher order, a controlled hexagonal packing of the helices into DNA‐like bundles and toroids could be accomplished. The results disclose unknown similarities between covalent and supramolecular non‐covalent helical polyelectrolytes, which inspire visionary ideas of constructing supramolecular versions of biological macromolecules. As drug nanocarriers the polymer–bile salt superstructures would get advantage of a complex chirality at molecular and supramolecular levels, whose effect on the nanocarrier assisted drug efficiency is a still unexplored fascinating issue.

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Section: Resultsmentioning

confidence: 56%

Condensed Supramolecular Helices: The Twisted Sisters of DNA

Belić

Giudice

et al. 2021

Angewandte Chemie

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“…At elevated temperatures above the phase transition of PNIPAM, which is thermoresponsive, the colloidal stability decreases as found for a similar block copolymer–NaDC system. [11] …”

Section: Resultsmentioning

confidence: 99%

“…At elevated temperatures above the phase transition of PNIPAM, which is thermoresponsive,the colloidal stability decreases as found for as imilar block copolymer-NaDC system. [11] Analysis of the cross section of the bundle obtained from the cryogenic electron tomography (cryo-ET) 3D reconstruction of ar epresentative PNIPAM 65 -b-PAMPTMA(+ +) 20 -NaDC mixture at CR = 1(Figure S13 and Movie S1) revealed that the supramolecular helices were packed in ah exagonal lattice (Figures 1h,S 14b,a nd Movies S2, S3). An inter-helix distance of 5.5 nm and an inter-plane distance of 4.8 nm was estimated from the gray value analysis (Figure 1i).…”

Section: Methodsmentioning

confidence: 99%

Condensed Supramolecular Helices: The Twisted Sisters of DNA

Belić

Giudice

et al. 2021

Angew Chem Int Ed

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Condensation of DNAh elices into hexagonally packed bundles and toroids represents an intriguing example of functional organization of biological macromolecules at the nanoscale.T he condensation models are based on the unique polyelectrolyte features of DNA, however here we could reproduce aD NA-like condensation with supramolecular helices of small chiral molecules,t hereby demonstrating that it is am ore general phenomenon. We showt hat the bile salt sodium deoxycholate can form supramolecular helices upon interaction with oppositely charged polyelectrolytes of homopolymer or blockc opolymers.A th igher order,acontrolled hexagonal packing of the helices into DNA-like bundles and toroids could be accomplished. The results disclose unknown similarities between covalent and supramolecular non-covalent helical polyelectrolytes,w hich inspire visionary ideas of constructing supramolecular versions of biological macromolecules.A sd rug nanocarriers the polymer-bile salt superstructures would get advantage of ac omplex chirality at molecular and supramolecular levels,w hose effect on the nanocarrier assisted drug efficiency is as till unexplored fascinating issue.

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“…It was also found that the loss of water-solubility of PNIPAM with increasing temperature induces pronounced aggregation at a transition temperature, to provide aggregates with an interior containing dehydrated PNIPAM and a remarkably positive or negative charge depending on the mixture composition, thereby promoting the block copolymer–BA complex as versatile smart material for nanotechnological application. It was also demonstrated that precipitation of the complexes occurs at large fraction of BA as those encountered by sequestrants in the gastrointestinal track [ 142 ]. A thermoresponsive BAD was observed to interact with the same catanionic block copolymer to form a complex, for which an intriguing thermoresponse was revealed by scattering techniques and circular dichroism measurements [ 143 ].…”

Section: Ba Polymer Mixturesmentioning

confidence: 99%

Physiology and Physical Chemistry of Bile Acids

Gregorio

Cautela

Galantini

2021

IJMS

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Bile acids (BAs) are facial amphiphiles synthesized in the body of all vertebrates. They undergo the enterohepatic circulation: they are produced in the liver, stored in the gallbladder, released in the intestine, taken into the bloodstream and lastly re-absorbed in the liver. During this pathway, BAs are modified in their molecular structure by the action of enzymes and bacteria. Such transformations allow them to acquire the chemical–physical properties needed for fulling several activities including metabolic regulation, antimicrobial functions and solubilization of lipids in digestion. The versatility of BAs in the physiological functions has inspired their use in many bio-applications, making them important tools for active molecule delivery, metabolic disease treatments and emulsification processes in food and drug industries. Moreover, moving over the borders of the biological field, BAs have been largely investigated as building blocks for the construction of supramolecular aggregates having peculiar structural, mechanical, chemical and optical properties. The review starts with a biological analysis of the BAs functions before progressively switching to a general overview of BAs in pharmacology and medicine applications. Lastly the focus moves to the BAs use in material science.

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Effect of temperature on the association behavior in aqueous mixtures of an oppositely charged amphiphilic block copolymer and bile salt

Cited by 10 publications

References 96 publications

Condensed Supramolecular Helices: The Twisted Sisters of DNA

Condensed Supramolecular Helices: The Twisted Sisters of DNA

Condensed Supramolecular Helices: The Twisted Sisters of DNA

Physiology and Physical Chemistry of Bile Acids

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