Effect of temperature on low-energy nano-emulsification and phase behavior in water/polyoxyethylene sorbitan fatty acid ester (Tweens®)/vegetable oil systems

Prasert, Waraporn; Gohtani, Shoichi

doi:10.1016/j.jfoodeng.2016.02.014

Cited by 9 publications

(6 citation statements)

References 15 publications

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“…Increasing emulsification-energy input by raising the temperature from 50°C to 60°C led to a significant increase in droplet size from 14.74 to 30.19 nm. This result corresponds with a reported study, 48 which indicated that bigger droplet sizes were produced when The original oil drop rapidly divided into many small oil drops at moderately high temperatures, inducing fast dispersion and high degree of dispersion of the emulsion. 49 The nature of the oil phase also alters phase-inversion temperature.…”

Section: Effect Of Emulsification Temperaturesupporting

confidence: 92%

Formulation, development, and optimization of a novel octyldodecanol-based nanoemulsion for transdermal delivery of ceramide IIIB

Su¹,

Yang²,

Wang³

et al. 2017

IJN

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This research aimed to develop and optimize a nanoemulsion-based formulation containing ceramide IIIB using phase-inversion composition for transdermal delivery. The effects of ethanol, propylene glycol (PG), and glycerol in octyldodecanol and Tween 80 systems on the size of the nanoemulsion region in the phase diagrams were investigated using water titration. Subsequently, ceramide IIIB loading was kept constant (0.05 wt%), and the proposed formulation and conditions were optimized via preliminary screening and experimental design. Factors such as octyldodecanol/(Tween 80:glycerol) weight ratio, water content, temperature, addition rate, and mixing rate were investigated in the preliminary screening experiment. Response surface methodology was employed to study the effect of water content (30%–70%, w/w), mixing rate (400–720 rpm), temperature (20°C–60°C), and addition rate (0.3–1.8 mL/min) on droplet size and polydispersity index. The mathematical model showed that the optimum formulation and conditions for preparation of ceramide IIIB nanoemulsion with desirable criteria were a temperature of 41.49°C, addition rate of 1.74 mL/min, water content of 55.08 wt%, and mixing rate of 720 rpm. Under optimum formulation conditions, the corresponding predicted response values for droplet size and polydispersity index were 15.51 nm and 0.12, respectively, which showed excellent agreement with the actual values (15.8 nm and 0.108, respectively), with no significant ( P >0.05) differences.

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Section: Effect Of Emulsification Temperaturesupporting

confidence: 92%

Formulation, development, and optimization of a novel octyldodecanol-based nanoemulsion for transdermal delivery of ceramide IIIB

Su¹,

Yang²,

Wang³

et al. 2017

IJN

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“…Even at this high surfactant concentration, the mean droplet sizes are generally >10 μm. 40 Consequently, SL-esters have improved emulsification performance when compared to many currently used commercial surfactants.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…Another study evaluated the emulsification of a vegetable oil with polysorbate surfactants using a water/surfactant/oil ratio of 0.8:0.1:0.1 and a similar homogenization method. Even at this high surfactant concentration, the mean droplet sizes are generally >10 μm . Consequently, SL-esters have improved emulsification performance when compared to many currently used commercial surfactants.…”

Section: Resultsmentioning

confidence: 99%

Effect of Sophorolipid n-Alkyl Ester Chain Length on Its Interfacial Properties at the Almond Oil–Water Interface

2016

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Sophorolipids (SLs), produced by Candida bombicola, are of interest as potential replacements for hazardous commercial surfactants. For the first time, a series of molecularly edited SLs with ethyl (EE), n-hexyl (HE), and n-decyl (DE) esters were evaluated at an oil (almond oil)-water interface for their ability to reduce interfacial tension (IFT) and generate stable emulsions. An increase in the n-alkyl ester chain length from ethyl to hexyl resulted in a maximum % decrease in the IFT from 86.1 to 95.3, respectively. Furthermore, the critical aggregation concentrations (CACs) decreased from 0.035 to 0.011 and 0.006 mg/mL as the ester chain length was increased from ethyl to n-hexyl and n-decyl, respectively. In contrast, the CAC of natural SL, composed of 50/50 acidic and LSL, is 0.142 mg/mL. Dynamic IFT analysis showed significant differences in diffusion coefficients for all SLs studied. Almond oil emulsions with up to 200:1 (by weight) oil/SL-DE were stable against oil separation for up to 1 week with average droplet sizes below 5 μm. Emulsions of almond oil with natural SLs showed consistent oil separation 24 h after emulsification. A unique connection between IFT and emulsification was found as SL-DE has both the lowest CAC and the best emulsification performance of all natural and modified SLs studied herein. This connection between CAC and emulsification may be generally applicable, providing a tool for the prediction of optimal surfactants in other oil-water interfacial applications.

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“…Brij 97 as a surfactant is used to construct LLC (Chen et al, ; Ma et al, ; Wang et al, , ), and the LLC constructed by surfactant mixture of Brij 97 and other surfactants was also studied (Fan et al, ; Li et al, ). Tween 40 has also been used to construct LLC (Prasert and Gohtani, , b), but it has rarely been reported to form LLC with other surfactants. Oleic acid (OLA) is an indispensable substance widely found in animals and plants, and, it is generally recognized as safe (GRAS listed) unsaturated fatty acid (Ibrahim and Li, ).…”

Section: Introductionmentioning

confidence: 99%

The Investigations of Construction and in vitro Release of Curcumin Lyotropic Liquid Crystals: Phase Diagrams, Small Angle X‐ray Scattering, Rheological Technology, and Release Kinetics

Liu

Wang

2019

J Surfact & Detergents

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In this study, hexagonal and cubic lyotropic liquid crystals (LLC) were constructed in Brij 97‐Tween 40 (MS82, MS64 and MS46)/OLA/H2O systems to encapsulate curcumin. MS82, MS64, and MS46 indicated that the mass ratio of Brij 97/Tween 40 was 8/2, 6/4, and 4/6. The microstructure of curcumin LLC was studied using small angle X‐ray scattering (SAXS). Phase diagrams showed that the increase of MS reduced the phase transition temperature (TC). Particularly, the TC of sample C1Cur [Brij 97‐Tween 40 (MS46)/OLA/H2O = 50.0/2.8/47.2] and C2Cur [Brij 97‐Tween 40 (MS46)/OLA/H2O = 50.0/25.0/25.0] was 37.6 and 35.4 °C, respectively, close to the temperature of the human body. Thus, the shear rheology and SAXS were used to study the structural changes of samples C1Cur and C2Cur with temperature. The moduli values of samples C1Cur and C2Cur decreased with the increase of temperature, showing various structural strengths. in vitro release experiment was used to study the drug release kinetics. The release of curcumin from LLC conformed to the concentration diffusion model. Due to a similar aS, the release of curcumin from samples A1Cur, B1Cur, and C1Cur (Brij 97‐Tween 40/OLA/H2O = 50.0/2.8/47.2 and the MS is MS82, MS64, and MS46) showed a similar release behavior under different MS. The release behavior of curcumin was related to the structure of samples C1Cur and C2Cur at different temperatures. Curcumin exhibited the fastest release rate when the samples behaved as the micellar phase.

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Effect of temperature on low-energy nano-emulsification and phase behavior in water/polyoxyethylene sorbitan fatty acid ester (Tweens®)/vegetable oil systems

Cited by 9 publications

References 15 publications

Formulation, development, and optimization of a novel octyldodecanol-based nanoemulsion for transdermal delivery of ceramide IIIB

Formulation, development, and optimization of a novel octyldodecanol-based nanoemulsion for transdermal delivery of ceramide IIIB

Effect of Sophorolipid n-Alkyl Ester Chain Length on Its Interfacial Properties at the Almond Oil–Water Interface

The Investigations of Construction and in vitro Release of Curcumin Lyotropic Liquid Crystals: Phase Diagrams, Small Angle X‐ray Scattering, Rheological Technology, and Release Kinetics

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