Effect of temperature on gastric intramucosal P CO 2 measurement by saline and air tonometry

Dohgomori, Hiroshi; Arikawa, K; Kanmura, Yuichi

doi:10.1007/s00540-003-0190-8

Cited by 3 publications

(1 citation statement)

References 6 publications

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“…This CO 2 production is probably caused by buffering of bicarbonate with the amino acids of the proteins of the meal (NH 3 ' '/ HCO 3 ( 0/NH 3 OH'/CO 2 ). A dinner as provocation meal demonstrates the greatest disturbance of CO 2 measurements, which can be explained by the fact that dinner is the most ''uncontrolled'' meal, owing to different factors: 1) chewing of the meal which adds bicarbonate to the gastric contents via the saliva [13], 2) relatively large amount of proteins, and 3) differences in temperature after ingestion of this meal [14,15]. Although theoretically a perfect test meal, with minimal in vitro production and absorption of CO 2 , the fat-predominant meal was practically intolerable for most subjects, and is therefore clinically useless.…”

Section: Discussionmentioning

confidence: 99%

Effect of various test meals on gastric and jejunal carbon dioxide: A study in healthy subjects

Mensink

Geelkerken²,

Huisman

et al. 2006

Scandinavian Journal of Gastroenterology

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Section: Discussionmentioning

confidence: 99%

Effect of various test meals on gastric and jejunal carbon dioxide: A study in healthy subjects

Mensink

Geelkerken²,

Huisman

et al. 2006

Scandinavian Journal of Gastroenterology

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Organ dysfunction assessment score for severe head injury patients during brain hypothermia

et al.

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Gastric Tonometry as a Prognostic Index of Mortality in Sepsis

Upadhyay

Vp²,

Murthy

2007

Medical Journal Armed Forces India

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Background: Splanchnic hypoperfusion in sepsis leads to translocation of bacteria from gut and development of multi-organ dysfunction syndrome (MODS), with increased mortality in critically ill patients. Gastric tonometry can detect this hypoperfusion by measuring carbon dioxide tension (PgCO 2 ) and intramucosal pH (pHi) from gastric mucosa. Therapeutic intervention aimed at improving gut perfusion can improve the outcome and prognosticate the mortality in sepsis patients. Methods: 100 patients with clinical diagnosis of sepsis were included and divided into two groups of 50 each. Group A patients were managed traditionally without gastric tonometry and in Group B gastric tonometry was used for therapeutic intervention. The intramucosal PCO 2 , pHi, end tidal carbon dioxide tension (EtCO 2 ) and (PgCO 2 -EtCO 2 ) differences were monitored at 0, 12 and 24 hours interval. Result: Overall mortality in Group A was 64% and 54% in Group B. In Group B 45% patients developed MODS and 54% died with low pHi. As an index of mortality low pHi had a sensitivity of 70% and specificity of 65%. Conclusion: There is a good correlation between mortality prediction on the basis of pHi and PgCO 2 -EtCO 2 difference and actual mortality in critically ill patients. The gastric tonometer should be used to predict mortality and guide resuscitation in septicemia.

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Effect of temperature on gastric intramucosal P CO 2 measurement by saline and air tonometry

Cited by 3 publications

References 6 publications

Effect of various test meals on gastric and jejunal carbon dioxide: A study in healthy subjects

Effect of various test meals on gastric and jejunal carbon dioxide: A study in healthy subjects

Organ dysfunction assessment score for severe head injury patients during brain hypothermia

Gastric Tonometry as a Prognostic Index of Mortality in Sepsis

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