Effect of temperature on curcumin solubility in a pressurized hot water solvent: Experimental and molecular dynamics simulation

Gazmeh, Motahareh; Khajenoori, Maryam; Yousefi-Nasab, Sadegh

doi:10.1016/j.icheatmasstransfer.2023.106918

Cited by 4 publications

(1 citation statement)

References 40 publications

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“…The application of AMF allows an increase in the temperature, and therefore the solubility of both molecules is improved. CUR s solubility in water is temperature dependent; is it possible to achieve a 12-fold increase at 90 °C with respect to room temperature [39][40][41]. Meanwhile for KET, despite the drug being soluble in water, the bioavailability and availability can be improved using heat, pH and other components in the dosage form [42][43][44].…”

Section: Alternating Magnetic Field Onmentioning

confidence: 99%

Remote-Controlled Activation of the Release through Drug-Loaded Magnetic Electrospun Fibers

Ziegler,

Ilyas,

Mathur

et al. 2024

Fibers

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The integration of magnetic nanoparticles within fibrillar structures represents an interesting avenue for the remotely controlled release of therapeutic agents. This work presents a novel drug release platform based on electrospun magnetic fibers (EMFs) combining drugs, magnetic nanoparticles (MNPs) and mesoporous silica nanoparticles (MSNs) for controlled drug delivery via alternating magnetic fields (AMF). The platform was demonstrated to be versatile and effective for hydrophilic ketorolac (KET) and hydrophobic curcumin (CUR) encapsulation and the major response observed for AMF-triggered release was reached using drug-loaded MSNs within the fibers, providing fine control over drug release patterns. The EMFs exhibited excellent inductive heating capabilities, showing a temperature increase of ∆T up to 8 °C within a 5 min AMF pulse. The system is shown to be promising for applications like transdermal pain management, oncological drug delivery, tissue engineering, and wound healing, enabling precise control over drug release in both spatial and temporal dimensions. The findings of this study offer valuable insights into the development of the next generation of smart drug delivery systems, based in multifunctional materials that can be remotely regulated and potentially revolutionize the field of nanomedicine.

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Section: Alternating Magnetic Field Onmentioning

confidence: 99%

Remote-Controlled Activation of the Release through Drug-Loaded Magnetic Electrospun Fibers

Ziegler,

Ilyas,

Mathur

et al. 2024

Fibers

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Application of molecular dynamics simulations in interface interaction of clay: Current status and perspectives

Chen

Chu

Cheng

et al. 2023

Asia-Pacific J Chem Eng

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To understand the research progress of molecular dynamics (MD) method in the field of clay minerals, the application of MD in the interface interaction of clay minerals is reviewed in this paper. MD simulations have become the indispensable means to study mineral interface effects. Clay minerals are common associated minerals with hydrophilic surface, the ease of argillization, negative electricity, and the ability of forming impurities and defects. They are widely concerned in the fields of mine wastewater treatment, fine clay mineral flotation, shale oil and gas exploitation, and so forth. In addition, clay minerals are considered as natural adsorbents due to their large specific surface area, but their complex interface interactions hinder their effective utilization. Therefore, it is particularly important to reveal the interaction mechanism of clay interface at the atomic/molecular level by means of software simulation technology. In this review, our focus is on the applications of MD method in the field of clay mineral interface interaction, such as clay/gas interface, clay/water interface, agents and clay/water interface, and mineral particle and clay/water interface. Furthermore, the history and shortcomings of MD simulation are summarized. The research and effective utilization of clay interface are summarized and prospected as well.

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Solubility of curcumin in subcritical water: Experimental data, modeling, and thermodynamic parameters

Simiari,

Khajenoori,

Haghighi Asl

2024

The Journal of Chemical Thermodynamics

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Effect of temperature on curcumin solubility in a pressurized hot water solvent: Experimental and molecular dynamics simulation

Cited by 4 publications

References 40 publications

Remote-Controlled Activation of the Release through Drug-Loaded Magnetic Electrospun Fibers

Remote-Controlled Activation of the Release through Drug-Loaded Magnetic Electrospun Fibers

Application of molecular dynamics simulations in interface interaction of clay: Current status and perspectives

Solubility of curcumin in subcritical water: Experimental data, modeling, and thermodynamic parameters

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