Effect of Telmisartan Versus Captopril on Insulin Resistance in Hypertensive Type 2 Diabetic Patients

Zainal, Adnan A.; Al-Hamamy, Fadhel

doi:10.33899/mjn.2014.162935

Cited by 2 publications

(2 citation statements)

References 32 publications

(35 reference statements)

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“…Which is a complex inflammatory disease (7,8). And significant risk factors for atherosclerosis are cholesterol and triglyceride; this plays an important role in initiating coronary artery disease and atheroma plaque formation (9). The etiology of these disorders is complicated by oxidative stress.…”

Section: Introductionmentioning

confidence: 99%

Effects of Hypericum perforatum on serum lipid vascular systems in mice

Hamed¹,

Abed²,

Almashhadany³

et al. 2022

IJVS

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Herbal products are increasingly used against lipid to attenuate its negative impact on vasculature system. However, there are uncertainty regarding the best administration approaches and preparation of herbal product to be used due to variation in absorption rate and extent with subsequent impaction on the lipid levels. The aim of the present study was comparing the pharmacological and analytical aspects of soaked versus powder form of Hypericum perforatum; a well-known anti-hyperlipidemic herbal product, using atorvastatin drug as a reference drug for comparison in addition to controlling groups (on/off lipid diet) handled as an additional control group. To conduct this research, the hyperlipidemia mice models were created by exposing the mice to a fatty diet and using H. perforatum and atorvastatin for evaluation. The plant extracts were also analyzed for active constituents. The results indicate that the plant analysis detected the presence of different antihyperlipidemic agents and the plant has effectively reduced plasma lipid parameters in exposed mice compared to control group; especially when taken forms of the plant was used. The study concluded that; soaked H. perforatum extract shown an effective reduction of lipid parameters and analysis of which revealed the presence of herbal active constituent which might be utilized in industrial pharmacy for new drug innovation.

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Section: Introductionmentioning

confidence: 99%

Effects of Hypericum perforatum on serum lipid vascular systems in mice

Hamed¹,

Abed²,

Almashhadany³

et al. 2022

IJVS

View full text Add to dashboard Cite

show abstract

“…In animal models, higher susceptibility to depression and anxiety is linked to ulceration, the same will be valid in human beings 7,8 . Furthermore, typical antidepressants and anxiolytics can greatly minimize the onset of stress ulcers, possibly to a significant degree than typical therapy like cimetidine and antacids 9,10 .…”

Section: Introductionmentioning

confidence: 99%

Fluvoxamine Provide a Gastro-Protection Against Vitiated Insult

Sada W. Abdulqader,

Ibrahim M. Faisal,

M. G. Saeed

et al. 2021

Indian Journal of Forensic Medicine & Toxicology

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The etiology of peptic ulcer disease is multifactorial and remains an enigma over the last decades. The central parameter is the acid secretion; whose control is under the coordination of gastrin, acetylcholine, histamine, and prostaglandin. The treatment of peptic ulcers is a bi-armed tool, directed toward fighting microbial growth alongside acid suppression. However recent studies reported failure of the therapy due to recurrence of symptoms. Therefore, additional parameters should be considered including patient mood and psychological status. The present study aimed to introduce a new approach to the therapeutic regimen of ulcer disease using commonly used antidepressant drugs (fluvoxamine and fluoxetine) in a laboratory animal model of peptic ulcer induced by stress insult to act as a mood upset model in an attempt to mimic mood changes in human. The study was conducted on 4 groups of laboratory animals using control negative and control positive (misoprostol) against the tested drugs group (fluvoxamine and fluoxetine group). The result confirmed that fluvoxamine confers gastroprotective effects against ulcer insult compared to both fluoxetine or misoprostol groups. These results might significantly mean that antidepressant drugs could be utilized in peptic ulcer diseases or added at low doses to prevent ulcer insults due to whatever precipitating factors, such as, infection, alcohol, smoking, NSAIDs, and stress ulcer.

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Effect of Telmisartan Versus Captopril on Insulin Resistance in Hypertensive Type 2 Diabetic Patients

Cited by 2 publications

References 32 publications

Effects of Hypericum perforatum on serum lipid vascular systems in mice

Effects of Hypericum perforatum on serum lipid vascular systems in mice

Fluvoxamine Provide a Gastro-Protection Against Vitiated Insult

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