Effect of telmisartan on the expression of cardiac adiponectin and its receptor 1 in type 2 diabetic rats

Guo, Zhixin; Zheng, Caihong; Qin, Zhihong; Wei, Ping

doi:10.1111/j.2042-7158.2010.01157.x

Cited by 23 publications

(19 citation statements)

References 35 publications

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“…SREBP1, which is negatively regulated by AMPK, is a major regulator of fatty acid synthesis [32]. Consistent with the observation that AMPK inhibits lipogenesis by reducing SREBP1 expression and by activating glucose uptake via GLUT4 upregulation [27,33], ALA reversed the increase in the levels of SREBP1 and decreased the levels of GLUT4 in OLETF rat hearts. In our previous study, we also confirmed the effect of ALA on SREBP1 and GLUT4 expression in non-alcoholic fatty liver disease of OLETF rats [27].…”

Section: Discussionmentioning

confidence: 58%

Alpha-lipoic acid attenuates cardiac fibrosis in Otsuka Long-Evans Tokushima Fatty rats

Lee

Jeon

et al. 2012

Cardiovasc Diabetol

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BackgroundHyperglycemia leads to cardiac oxidative stress and an imbalance in glucose homeostasis. Diabetic cardiomyopathy is characterised by cardiac hypertrophy and fibrosis. However, the underlying mechanisms of diabetic cardiomyopathy are not fully understood. This study aimed to investigate the effects of alpha-lipoic acid (ALA) on cardiac energy metabolism, antioxidant effect, and fibrosis in the hearts of Otsuka Long-Evans Tokushima fatty (OLETF) rats.MethodsAnimals were separated into non-diabetic Long-Evans Tokushima Otsuka (LETO) rats and diabetes-prone OLETF rats with or without ALA (200 mg/kg/day) administration for 16 weeks. Diabetic cardiomyopathy was assessed by staining with Sirius Red. The effect of ALA on AMPK signalling, antioxidant enzymes, and fibrosis-related genes in the heart of OLETF rats were performed by Western blot analysis or immunohistochemistry.ResultsWestern blot analysis showed that cardiac adenosine monophosphate-activated kinase (AMPK) signalling was lower in OLETF rats than in LETO rats, and that ALA treatment increased the signalling in OLETF rats. Furthermore, the low antioxidant activity in OLETF rats was increased by ALA treatment. In addition to increased Sirius red staining of collagen deposits, transforming growth factor-β1 (TGF-β1) and connective tissue growth factor (CTGF) were expressed at higher levels in OLETF rat hearts than in LETO rat hearts, and the levels of these factors were decreased by ALA.ConclusionsALA enhances AMPK signalling, antioxidant, and antifibrogenic effect. Theses findings suggest that ALA may have beneficial effects in the treatment of diabetic cardiomyopathy.

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Section: Discussionmentioning

confidence: 58%

Alpha-lipoic acid attenuates cardiac fibrosis in Otsuka Long-Evans Tokushima Fatty rats

Lee

Jeon

et al. 2012

Cardiovasc Diabetol

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“…Insulin sensitivity index (ISI) were significantly reduced in diabetic rats compared to controls and telmisartan treatment significantly increased the insulin sensitivity index in diabetic rats. The ratio of heart weight to body weight, an index of cardiac hypertrophy, was significantly increased in diabetic rats compared to controls and telmisartan treatment significantly decreased the ratio of heart weight to body weight in diabetic rats (See table one in reference [6], a paper we previously published. The samples we used in this paper were the same as in reference [6]).…”

Section: Resultsmentioning

confidence: 99%

“…Telmisartan treatment significantly increased plasma and myocardial adiponectin levels in diabetic rats (See Table two in reference [6], a paper we previously published. The samples we used in this paper were the same as in reference [6]).…”

Section: Resultsmentioning

confidence: 99%

“…Adiponectin receptor type 1 and adiponectin receptor type 2 are not only expressed in skeletal muscle and liver, but also in heart and kidney [5]. Our previous study showed that the expression of myocardial adipoR1 was significantly decreased in type 2 diabetic rats [6]. It is unknown whether the expression of adipoR2 in the heart and the expression of adipoR1 in aorta are also changed in type 2 diabetic rat.…”

Section: Introductionmentioning

confidence: 99%

“…Telmisartan normalizes vascular dysfunction and reduces platelet activation in diabetic rats [20]. Our previous study showed that telmisartan treatment significantly attenuated the decreased expression of myocardial adipoR1 in diabetic rats [6]. It is unknown whether the expression of adipoR2 and NADPH oxidase subunits in the heart and the expression of adipoR1 in aorta are changed by telmisartane treatment in type 2 diabetic rats.…”

Section: Introductionmentioning

confidence: 99%

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Effect of telmisartan on the expression of adiponectin receptors and nicotinamide adenine dinucleotide phosphate oxidase in the heart and aorta in type 2 diabetic rats

Guo

Zhang

et al. 2012

Cardiovasc Diabetol

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BackgroundDiabetic cardiovascular disease is associated with decreased adiponectin and increased oxidative stress. This study investigated the effect of telmisartan on the expression of adiponectin receptor 2 (adipoR2) and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase subunits in the heart and the expression of adiponectin receptor 1 (adipoR1) in aorta in type 2 diabetic rats.MethodsType 2 diabetes was induced by high-fat and high-sugar diet and intraperitoneal injection of a low dose of streptozotocin (STZ). Heart function, adipoR2, p22phox, NOX4, glucose transporter 4(GLUT4), monocyte chemoattractant protein-1(MCP-1) and connective tissue growth factor (CTGF)in the heart, and adipoR1, MCP-1 and nuclear factor kappa B (NF-κB) in aorta were analyzed in controls and diabetic rats treated with or without telmisartan (5mg/kg/d) by gavage for 12 weeks.ResultsHeart function, plasma and myocardial adiponectin levels, the expression of myocardial adipoR2 and GLUT4 were significantly decreased in diabetic rats (P <0.05). The expression of myocardial p22phox, NOX4, MCP-1, and CTGF was significantly increased in diabetic rats (P <0.05). The expression of adipoR1 was decreased and the expression of MCP-1 and NF-κB was increased in the abdominal aorta in diabetic rats (P <0.05). Telmisartan treatment significantly attenuated these changes in diabetic rats (P <0.05).ConclusionsOur results suggest that telmisartan upregulates the expression of myocardial adiponectin, its receptor 2 and GLUT4. Simultaneously, it downregulates the expression of myocardial p22phox, NOX4, MCP-1, and CTGF, contributing so to the improvement of heart function in diabetic rats. Telmisartan also induces a protective role on the vascular system by upregulating the expression of adipoR1 and downregulating the expression of MCP-1 and NF-κB in the abdominal aorta in diabetic rats.

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Modulation of Vascular Reactivity by Perivascular Adipose Tissue (PVAT)

et al. 2018

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PVAT possesses a relevant endocrine-paracrine activity, which may be altered in several pathophysiological and clinical conditions. During the last two decades, it has been shown that PVAT may modulate vascular reactivity. It has also been previously demonstrated that inflammation in adipose tissue may be implicated in vascular dysfunction. In particular, adipocytes secrete a number of adipokines with various functions, as well as several vasoactive factors, together with components of the renin-angiotensin system which may act at local or at systemic level. It has been shown that the anti-contractile effect of PVAT is lost in obesity, probably as a consequence of the development of adipocyte hypertrophy, inflammation, and oxidative stress. Adipose tissue dysfunction is interrelated with inflammation and oxidative stress, thus contributing to endothelial dysfunction observed in several pathological and clinical conditions such as obesity and hypertension. Decreased local adiponectin level, macrophage recruitment and infiltration, and activation of renin-angiotensin-aldosterone system could play an important role in this regard.

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Effect of telmisartan on the expression of cardiac adiponectin and its receptor 1 in type 2 diabetic rats

Cited by 23 publications

References 35 publications

Alpha-lipoic acid attenuates cardiac fibrosis in Otsuka Long-Evans Tokushima Fatty rats

Alpha-lipoic acid attenuates cardiac fibrosis in Otsuka Long-Evans Tokushima Fatty rats

Effect of telmisartan on the expression of adiponectin receptors and nicotinamide adenine dinucleotide phosphate oxidase in the heart and aorta in type 2 diabetic rats

Modulation of Vascular Reactivity by Perivascular Adipose Tissue (PVAT)

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