Effect of Tegretol on Oxidative Stress, Serum Inflammatory Factors, and Left Ventricular Function in AMI Patients after Emergency PCI

Abstract

To investigate the effects of tegretol on oxidative stress, serum inflammatory factors, and left ventricular function in patients with acute myocardial infarction (AMI) after emergency percutaneous coronary intervention (PCI), 70 AMI patients who received PCI in the emergency department of our hospital from January 2021 to December 2021 were collected. The patients in the control group were treated with aspirin, clopidogrel, and heparin sodium during the perioperative period, and the patients in the study group were treated with tegretol. The levels of oxidative stress, serum inflammatory factors, and left ventricular function index were compared between the two groups. The patients in the control group were treated with TT (( 12.00 ± 2.05 ) s), APTT (( 35.50 ± 4.19 ) s), PT (( 16.60 ± 1.58 ) s), TT (( 15.90 ± 2.14 ) s) APTT (( 30.40 ± 3.80 ) s), and PT (( 14.30 ± 1.45 ) s)) and were comparable ( P > 0.05 ), and the difference was statistically significant ( t = 8.210 , 4.600, 7.010, P < 0.001 ). There was no comparable difference in the level of oxidative stress index before treatment ( P > 0.05 ). After treatment, there was significant difference in MDA (( 14.53 ± 2.14 ) mmol/L), SOD (( 120.45 ± 8.17 ) U/L), MDA (( 11.15 ± 2.02 ) mmol/L), and SOD (( 129.86 ± 8.55 ) U/L) in the control group ( t = 7.320 , 5.099, P < 0.001 ). The levels of inflammatory factors in patients before treatment were not comparable ( P > 0.05 ). After treatment, there were levels of IL-6 (( 3.20 ± 1.05 ) ng/L), CRP (( 4.80 ± 1.16 ) mg/L), MPO (( 196.78 ± 21.51 ) mg/L) and TNF-α (( 3.96 ± 0.80 ) pmol/L), IL-6 (( 1.95 ± 0.80 ) ng/L), CRP (( 3.10 ± 1.02 ) mg/L), MPO (( 163.60 ± 21.10 ) mg/L), and TNF-α in a study group level (( 3.05 ± 0.70 ) pmol/L), with statistically significant difference ( t = 5.187 , 6.028, 6.031, 4.689, P < 0.001 ). Before treatment, there was no comparable difference in the level of left ventricular function index ( P > 0.05 ). After treatment, there was significant difference in LVEF ((46.10 ± 2.39) %) and LVDD ((52.06 ± 1.07) mm), LVEF ((56.85 ± 2.33) %), and LVDD ((48.75 ± 1.02) mm) in the control group ( t = 17.640 , 21.540, P < 0.001 ). Tegretol as an adjunctive therapy for emergency PCI patients with acute myocardial infarction can effectively improve postoperative coagulation function, reduce oxidative stress and inflammatory reaction, and improve cardiac function indicators. It has a positive clinical value.

Clinical Application of PINK1 and ACSL4 Protein Levels in the Acute Myocardial Infarction Patients and Prognosis Evaluation After PCI

“…However, some patients may experience ventricular remodeling after PCI, with related nerves activated, increased inflammation response, leading to complications such as pneumonia and heart failure, which can also pose a threat to patients' health. 14,15 At present, T-ProBNP, GDF15 and other biomarkers commonly used in clinical practice are susceptible to multiple factors such as autoimmune system disorders and inflammation, and the prediction accuracy is low. 16 Therefore, it is particularly important to find specific factors that can assist in diagnosis and prediction of the prognosis of patients with acute myocardial infarction.…”

Serum oxidative stress factors predict myocardial ischemia reperfusion injury after percutaneous coronary intervention in patients with acute myocardial infarction and type 2 diabetes mellitus

“…Acute myocardial infarction (AMI) results in ventricular remodeling in response to oxygen demand, which is characterized by left ventricular dilatation and elevated myocardial wall stress [1,2]. Percutaneous coronary interven-tion (PCI) has been regarded as a gold standard therapy for AMI therapy to restore coronary blood flow [3,4]. AMI is a frequent reason for fatality in patients with type 2 diabetes mellitus (T2DM) and vascular dysfunction is a main ingredient of diabetic cardiomyopathy [5].…”

Retracted: Effect of Tegretol on Oxidative Stress, Serum Inflammatory Factors, and Left Ventricular Function in AMI Patients after Emergency PCI

“…This article has been retracted by Hindawi following an investigation undertaken by the publisher [1]. This investigation has uncovered evidence of one or more of the following indicators of systematic manipulation of the publication process:…”

“…This article has been retracted by Hindawi following an investigation undertaken by the publisher [ 1 ]. This investigation has uncovered evidence of one or more of the following indicators of systematic manipulation of the publication process: Discrepancies in scope Discrepancies in the description of the research reported Discrepancies between the availability of data and the research described Inappropriate citations Incoherent, meaningless and/or irrelevant content included in the article Peer-review manipulation …”