Effect of tear secretory IgA on chemotaxis of polymorphonuclear leucocytes

Lan, J; Willcox, Mark; Jackson, G. D. F.; Thakur, Archana

doi:10.1111/j.1442-9071.1998.tb01367.x

Cited by 12 publications

(8 citation statements)

References 8 publications

(1 reference statement)

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“…After treatment, IL‐8 levels were significantly reduced; therefore, the level of IL‐8 is directly correlated with levels of Dsg1‐specific IgA and disease activity. Our data are consistent with previous reports that showed a positive correlation between levels of IL‐8 and IgA antibodies in the circulation 1–3 . These findings indicate that the increased IgA and IL‐8 levels may be responsible for recruiting and activating neutrophils in these IgA‐mediated skin conditions 1–3 …”

Section: Discussionsupporting

confidence: 92%

“…Our data are consistent with previous reports that showed a positive correlation between levels of IL-8 and IgA antibodies in the circulation. [1][2][3] These findings indicate that the increased IgA and IL-8 levels may be responsible for recruiting and activating neutrophils in these IgA-mediated skin conditions. [1][2][3] About 10 similar cases have been reported elsewhere with different clinical lesions, such as those of herpetiformis, erythematosus, foliaceus, and vegetation type, and with coexistence of IgA and IgG autoantibodies against Dsg1/Dsg3/desmocollins in the circulation.…”

Section: Discussionmentioning

confidence: 99%

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A case of IgA/IgG pustular pemphigus

Liu

Jin

et al. 2011

Int J Dermatology

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

A case of IgA/IgG pustular pemphigus

Liu

Jin

et al. 2011

Int J Dermatology

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“…Thus sIgA is of great importance as it facilitates removal of pathogens right at the point of entry at the ocular surface. sIgA has also been shown to be chemotactic for phagocytic neutrophils (Lan et al, 1998) and to prevent the binding of P. aeruginosa and Acanthamoeba polyphaga to contact lenses (Campos-Rodriguez et al, 2004; Lan et al, 1999). …”

Section: “Classic” Tear Antimicrobial Componentsmentioning

confidence: 99%

“…However the preponderance of studies suggest a decrease in sIgA with contact lens wear. This is of significance as this antibody has been shown to reduce binding of P. aeruginosa to contact lenses and be chemoattractive for phagocytic neutrophils (Lan et al, 1999; Lan et al, 1998). …”

Section: Modulation Of Tear Antimicrobialsmentioning

confidence: 99%

Antimicrobial compounds in tears

McDermott

2013

Experimental Eye Research

234

171

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The tear film coats the cornea and conjunctiva and serves several important functions. It provides lubrication, prevents drying of the ocular surface epithelia, helps provide a smooth surface for refracting light, supplies oxygen and is an important component of the innate defense system of the eye providing protection against a range of potential pathogens. This review describes both classic antimicrobial compounds found in tears such as lysozyme and some more recently identified such as members of the cationic antimicrobial peptide family and surfactant protein-D as well as potential new candidate molecules that may contribute to antimicrobial protection. As is readily evident from the literature review herein, tears, like all mucosal fluids, contain a plethora of molecules with known antimicrobial effects. That all of these are active in vivo is debatable as many are present in low concentrations, may be influenced by other tear components such as the ionic environment, and antimicrobial action may be only one of several activities ascribed to the molecule. However, there are many studies showing synergistic/additive interactions between several of the tear antimicrobials and it is highly likely that cooperativity between molecules is the primary way tears are able to afford significant antimicrobial protection to the ocular surface in vivo. In addition to effects on pathogen growth and survival some tear components prevent epithelial cell invasion and promote the epithelial expression of innate defense molecules. Given the protective role of tears a number of scenarios can be envisaged that may affect the amount and/or activity of tear antimicrobials and hence compromise tear immunity. Two such situations, dry eye disease and contact lens wear, are discussed here.

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“…The primary antibody present in tears is sIgA, which is produced in the lacrimal gland and works to prevent bacterial adhesion, aggregate neutralized pathogens, and allow clearance of the pathogens from the ocular surface 16b,26. It has also been associated with the increased chemotaxis of neutrophils and other immune cells during the prolonged period of eyelid closure during sleep 27. Tear lipids can also augment the bactericidal properties of tears, as short‐chain lipids affect the surface properties of the bacterial cell membrane, and long‐chain lipids have a direct effect on bacterial metabolism 20,28.…”

Section: Introduction: the Barriers To Topical Ocular Drug Deliverymentioning

confidence: 99%

Material, Immunological, and Practical Perspectives on Eye Drop Formulation

Bennett

Chinnery

Downie

et al. 2020

Adv Funct Materials

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Eye drops are the most common and inexpensive approach to topical ocular drug delivery. Eye drops offer a noninvasive treatment strategy; however, this can be detrimental to therapeutic efficacy when compared to invasive methods such as surgeries, implants, and injections. Improvements to the efficacy of the topical delivery of drugs to ocular tissues are currently being explored and much of this work centers on adjusting the formulation of the eye drops and prolonging the bioavailability of the therapeutic agent. This is often in preference to improving other patient‐focused or clinical factors. In this progress report, conventional, commercially available polymer eye drops are explored and the ability for current and future innovations to maintain the existing benefits of eye drops to the patient is assessed. The final materials and form of the drops (liquid, gel, or other) and the immunological implications for the user are explored. There is currently no consensus for how to most effectively improve the ocular retention and drug delivery capabilities of eye drops, but key issues are highlighted in the context of current methods under development, and potential questions and considerations for future innovations are raised.

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Effect of tear secretory IgA on chemotaxis of polymorphonuclear leucocytes

Abstract: The massive recruitment of PMN in tears during sleep may be partially attributed to the increased levels of tear sIgA. This may play an important role in protecting the eye against bacterial infection.

Cited by 12 publications

References 8 publications

A case of IgA/IgG pustular pemphigus

A case of IgA/IgG pustular pemphigus

Antimicrobial compounds in tears

Material, Immunological, and Practical Perspectives on Eye Drop Formulation

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