Effect of taurine supplementation on fat and energy absorption in cystic fibrosis.

Curtis, Mario De; Santamaria, Francesca; Ercolini, P; Vittoria, Luisa Nicoletti Stefania; Ritis, G De; Garofalo, Virginia; Ciccimarra, F

doi:10.1136/adc.67.9.1082

Cited by 12 publications

(6 citation statements)

References 16 publications

(5 reference statements)

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“…However, the beneficial effect of taurine supplementation on fat absorption is not unequivocally demonstrated [42][43][44][45]. Furthermore, the degree of fat absorption did not relate to changes in the serum glycine/taurine ratio in CF children [45].…”

Section: Intervention Studiesmentioning

confidence: 85%

Persistent fat malabsorption in cystic fibrosis; lessons from patients and mice

Wouthuyzen-Bakker

Bodewes

Verkade

2011

Journal of Cystic Fibrosis

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Fat malabsorption in pancreatic insufficient cystic fibrosis (CF) patients is classically treated with pancreatic enzyme replacement therapy (PERT). Despite PERT, intestinal fat absorption remains insufficient in most CF patients. Several factors have been suggested to contribute to the persistent fat malabsorption in CF (CFPFM). We reviewed the current insights concerning the proposed causes of CFPFM and the corresponding intervention studies. Most data are obtained from studies in CF patients and CF mice. Based on the reviewed literature, we conclude that alterations in intestinal pH and intestinal mucosal abnormalities are most likely to contribute to CFPFM. The presently available data indicate that acid suppressive drugs and broad spectrum antibiotics could be helpful in individual CF patients for optimizing fat absorption and/or nutritional status.

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Section: Intervention Studiesmentioning

confidence: 85%

Persistent fat malabsorption in cystic fibrosis; lessons from patients and mice

Wouthuyzen-Bakker

Bodewes

Verkade

2011

Journal of Cystic Fibrosis

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“…In CF, oral taurine load appears to be normal, but excessive fecal loss [153] increases the ratio of glycine/taurine-conjugated BA [94,140,141]. Oral taurine supplementation in CF children is effective in decreasing the glycine/taurine ratio in duodenal fluid [153], but its ability to improve fat malabsorption is controversial [154-157].…”

Section: Intraluminal Abnormalitiesmentioning

confidence: 99%

“…Oral taurine supplementation in CF children is effective in decreasing the glycine/taurine ratio in duodenal fluid [153], but its ability to improve fat malabsorption is controversial [154-157]. Apparently, taurine supplementation improves BA malabsorption, mainly in patients with a high degree of steatorrhea [158-160].…”

Section: Intraluminal Abnormalitiesmentioning

confidence: 99%

Mechanisms of lipid malabsorption in Cystic Fibrosis: the impact of essential fatty acids deficiency

et al. 2005

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Transport mechanisms, whereby alimentary lipids are digested and packaged into small emulsion particles that enter intestinal cells to be translocated to the plasma in the form of chylomicrons, are impaired in cystic fibrosis. The purpose of this paper is to focus on defects that are related to intraluminal and intracellular events in this life-limiting genetic disorder. Specific evidence is presented to highlight the relationship between fat malabsorption and essential fatty acid deficiency commonly found in patients with cystic fibrosis that are often related to the genotype. Given the interdependency of pulmonary disease, pancreatic insufficiency and nutritional status, greater attention should be paid to the optimal correction of fat malabsorption and essential fatty acid deficiency in order to improve the quality of life and extend the life span of patients with cystic fibrosis.

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“…Available human data from the use of taurine in human medicine do not give any indication of safety concerns (Franconi et al, 1995;Takahashi and Nakane, 1978;Fukuyama and Ochiai, 1982;Airaksinen et al, 1980;Mantovani and DeVibo, 1979;Marchesi et al, 1975;Mutani et al, 1975;Azuma et al, 1983a;1983b;Fujita et al, 1987;Yamori et al, 1996;Krøll and Lund, 1966;Yamamoto et al, 1994;Gentile et al, 1994;Matsuyama et al, 1983;Podda et al, 1990;Kimura et al, 1992;Obinata et al, 1996;Durelli et al, 1982;Nyland et al, 1989;Kopple et al, 1990;Thompson 1988;Darling et al, 1985;Carrasco et al, 1990;Belli et al, 1987;Colombo et al, 1988;Smith et al, 1991;De Curtis et al, 1992;Skopnik et al, 1991;Colombo et al, 1990).…”

Section: Human Datamentioning

confidence: 99%

The use of taurine and D-glucurono-gamma-lactone as constituents of the so-called “energy” drinks

2009

EFSA Journal

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SUMMARYFollowing a request from the Commission, the Scientific Panel on Food Additives and Nutrient Sources added to Food (ANS) has been asked to evaluate the safety-in-use of taurine and D-glucurono-γ-lactone as constituents of the so-called "energy" drinks.In the present opinion the Panel evaluates the safety of taurine and D-glucurono-γ-lactone as individual ingredients of so-called "energy" drinks based on the new studies provided by the petitioner.The Panel does not evaluate the safety of "energy" drinks as such.Taurine and D-glucurono-γ-lactone are constituents of the so-called "energy" drinks, but they also occur at much lower levels as natural ingredients in food, and they are also normal human metabolites. Previous Scientific Committee on Food (SCF) Opinions have summarized safety studies of taurine and D-glucurono-γ-lactone, but the safety-in-use of these The use of taurine and D-glucurono-γ-lactone as constituents of the so-called "energy" drinksThe EFSA Journal (2009) 935, 2-31 two ingredients at the levels of exposure expected from their use in "energy" drinks could not be established at that time.In the absence of new chronic and acute exposure data, the exposures used in this opinion are based on the data reported by the SCF in 2003, i.e. a daily mean chronic consumption of 0.5 cans per person and a high chronic exposure at the 95 th percentile of 1.4 cans per regular consumer. The Panel notes that actual exposure data on "energy" drink consumption, especially for adolescents and young adults, may need to be collected. Based on the assumption that a can contains 250 mL and 4000 mg/L taurine and 2400 mg/L D-glucurono-γ-lactone, the SCF calculated that these values result in a mean daily exposure to 500 mg taurine (8.3 mg taurine/kg bw/day for a 60 kg person) and 300 mg D-glucurono-γ-lactone (5.0 mg D-glucurono-γ-lactone/kg bw/day for a 60 kg person). The 95 th percentile exposure of regular users would amount to 1400 mg taurine/day (23.3 mg/kg bw/day for a 60 kg person) and 840 mg D-glucurono-γ-lactone /day (14 mg/kg bw/day for a 60 kg person).If it is assumed that this amount of chronic consumption is relevant to occasional exposure of children of 25 kg body weight, then their exposure (on a body weight basis) would be about 2.5 times higher than that for adults (60-65 kg body weight). It must be emphasized that these estimates relate to chronic exposures by average and high consuming adults, and would not reflect the occasional and sporadic exposure that might occur in children. If the frequency of exposure for children would be 2.5 times lower than for adults, then the average chronic exposure for children, on a body weight basis, would be the same as for adults. If children were to consume the adult intake of 0.5 and 1.4 cans per person only once per week, then the average chronic exposure to "energy" drinks and their constituents for children, on a body weight basis, would be one third of that for adults.These estimates for the daily exposure to taurine and D-glucurono-γ-lactone from "energy"...

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Effect of taurine supplementation on fat and energy absorption in cystic fibrosis.

Cited by 12 publications

References 16 publications

Persistent fat malabsorption in cystic fibrosis; lessons from patients and mice

Persistent fat malabsorption in cystic fibrosis; lessons from patients and mice

Mechanisms of lipid malabsorption in Cystic Fibrosis: the impact of essential fatty acids deficiency

The use of taurine and D-glucurono-gamma-lactone as constituents of the so-called “energy” drinks

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