Effect of Taurine Supplementation on Hepatic Function During Short-Term Parenteral Nutrition in the Premature Infant

Cooke, R. J.; Whitington, Peter F.; Kelts, Drew

doi:10.1097/00005176-198403000-00012

Cited by 54 publications

(14 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a hamster model, taurine supplementation increases bile flow rate as well as bile acid excretion rate 42 . However, there were no significant differences in liver biochemical tests with taurine supplementation 43 . Amino acid solutions have been formulated to match pediatric needs.…”

Section: Amino Acidsmentioning

confidence: 73%

Prevention and Treatment of Intestinal Failure-Associated Liver Disease in Children

Raphael

Duggan

2013

Semin Liver Dis

View full text Add to dashboard Cite

Intestinal failure-associated liver disease (IFALD), a serious complication occurring in infants, children and adults exposed to long-term parenteral nutrition (PN), causes a wide-spectrum of disease, ranging from cholestasis and steatosis to fibrosis and eventually cirrhosis. Known host risk factors for IFALD include low birth weight, prematurity, short bowel syndrome and recurrent sepsis. The literature suggests that components of PN may also play a part of the multifactorial pathophysiology. Because some intravenous lipid emulsions (ILE) may contribute to inflammation and interfere with bile excretion, treatment with ILE minimization and/or ILEs composed primarily of omega-3 fatty acids can be helpful but requires careful monitoring for growth failure and essential fatty acid deficiency (EFAD). Data from randomized controlled trials are awaited to support widespread use of these approaches. Other IFALD treatments include cycling PN, ursodeoxycholic acid, sepsis prevention, photoprotection and polyvinylchloride-free tubing. Management and prevention of IFALD remains a clinical challenge.

show abstract

Section: Amino Acidsmentioning

confidence: 73%

Prevention and Treatment of Intestinal Failure-Associated Liver Disease in Children

Raphael

Duggan

2013

Semin Liver Dis

View full text Add to dashboard Cite

show abstract

“…Short-term supplementation to parenteral nutrition of 20 premature infants at 10.8 mg/kg/day for 10 days did not result in a different effect on hepatic function. 200 In children dependent on home parenteral nutrition who developed cholestasis, supplementation did not improve liver function tests despite a significant increase in blood taurine concentrations. 201 In a retrospective review of the frequency of cholestasis in infants who received two different commercial parenteral amino acid formulations supplemented with taurine (25 and 70 mg/100 ml bulk solution), PNAC occurred in 21.4% of subjects (15/70 patients) in equal numbers of those who received either formulation for at least 14 days.…”

Section: Taurine Deficiencymentioning

confidence: 96%

Parenteral Nutrition‐Associated Liver Complications in Children

Btaiche

Khalidi

2002

Pharmacotherapy

View full text Add to dashboard Cite

Parenteral nutrition is a life-saving therapy for patients with intestinal failure. It may be associated with transient elevations of liver enzyme concentrations, which return to normal after parenteral nutrition is discontinued. Prolonged parenteral nutrition is associated with complications affecting the hepatobiliary system, such as cholelithiasis, cholestasis, and steatosis. The most common of these is parenteral nutrition-associated cholestasis (PNAC), which may occur in children and may progress to liver failure. The pathophysiology of PNAC is poorly understood, and the etiology is multifactorial. Risk factors include prematurity, long duration of parenteral nutrition, sepsis, lack of bowel motility, and short bowel syndrome. Possible etiologies include excessive caloric administration, parenteral nutrition components, and nutritional deficiencies. Several measures can be undertaken to prevent PNAC, such as avoiding overfeeding, providing a balanced source of energy, weaning parenteral nutrition, starting enteral feeding, and avoiding sepsis.

show abstract

“…In guinea pigs, oral supplementation increases bile flow and the taurine:glycine ratio of conjugate bile acids 23. It had been widely believed that taurine supplementation was responsible for the decreased incidence observed in neonatal PNALD,24, 25 although more recent data have suggested that it does not lead to a lower incidence of cholestasis 26–28. It is more likely that overall improvements in neonatal critical care, including treatment of sepsis, hypoxia, hypotension, and early enteral feeding, have contributed to the decline in the incidence of PNALD in this population 29…”

Section: Pathophysiologymentioning

confidence: 99%

Parenteral nutrition-associated liver disease and the role for isolated intestine and intestine/liver transplantation

2005

View full text Add to dashboard Cite

Parenteral nutrition-associated liver disease (PNALD) is the most devastating complication of long-term parenteral nutrition therapy. Because its progression is typically insidious and its long-term consequences are generally underappreciated, PNALD is often recognized too late, when liver injury is irreversible. When end-stage liver disease (ESLD) develops in these patients, most potential interventions are futile and transplantation of both an intestine and a liver becomes the only viable option, despite the relatively poor outcomes associated with this combined procedure. Although likely multifactorial in origin, the etiology of PNALD is poorly understood. Early clinical intervention with a combination of nutritional, medical, hormonal, and surgical therapies can be effective in preventing liver disease progression. If these interventions fail, intestinal transplantation should be performed expeditiously before development of ESLD mandates simultaneous inclusion of a liver graft as well. (HEPATOLOGY 2006;43:9-19.)

show abstract

Effect of Taurine Supplementation on Hepatic Function During Short-Term Parenteral Nutrition in the Premature Infant

Cited by 54 publications

References 0 publications

Prevention and Treatment of Intestinal Failure-Associated Liver Disease in Children

Prevention and Treatment of Intestinal Failure-Associated Liver Disease in Children

Parenteral Nutrition‐Associated Liver Complications in Children

Parenteral nutrition-associated liver disease and the role for isolated intestine and intestine/liver transplantation

Contact Info

Product

Resources

About