Effect of taurine on toxicity of oxidized fish oil in rats

Hwang, Deng‐Fwu; Hour, J.L; Cheng, Hao-Yuan

doi:10.1016/s0278-6915(00)00052-1

Cited by 36 publications

(23 citation statements)

References 14 publications

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“…Our study showed an elevated TBARS content in the liver of bullfrog oil-treated animals, which was associated with the increase in the PUFA/SFA ratio ( Table 1). These results agree with previous studies indicating that a high PUFA/SFA ratio in the diet is partially responsible for the increase of TBARS content leading to histological and functional damage in the liver (20).…”

supporting

confidence: 93%

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Effect of bullfrog (Rana catesbeiana) oil administered by gavage on the fatty acid composition and oxidative stress of mouse liver

Silva

Miyasaka

Martins

et al. 2004

Braz J Med Biol Res

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The aim of the present study was to investigate the effects of daily intragastric administration of bullfrog oil (oleic, linoleic and palmitoleic acid-rich oil), corresponding to 0.4% of body weight for four weeks, on fatty acid composition and oxidative stress (lipid peroxidation and catalase activity) in mouse liver. The activities of aspartate aminotransferase (AST), alkaline phosphatase (ALP), alanine aminotransferase (ALT), and gamma-glutamyltransferase (GGT), biomarkers of tissue injury, were determined in liver homogenates and serum. The proportions of 18:2n-6, 20:4n-6, 20:5n-3, and 22:6n-3 (polyunsaturated fatty acids, from 37 to 60%) in the total fatty acid content were increased in the liver of the bullfrog oil-treated group (P < 0.05) compared to control. At the same time, a significant decrease in the relative abundance of 14:0, 16:0, and 18:0 (saturated fatty acids, from 49 to 25%) was observed. The hepatic content of thiobarbituric acid reactive substances (TBARS) was increased from 2.3 ± 0.2 to 12.3 ± 0.3 nmol TBA-MDA/mg protein and catalase activity was increased from 840 ± 32 to 1110 ± 45 µmol reduced H 2 O 2 min -1 mg protein -1 in the treated group. Bullfrog oil administration increased AST and ALP activities in the liver (from 234.10 ± 0.12 to 342.84 ± 0.13 and 9.38 ± 0.60 to 20.06 ± 0.27 U/g, respectively) and in serum (from 95.41 ± 6.13 to 120.32 ± 3.15 and 234.75 ± 11.5 to 254.41 ± 2.73 U/l, respectively), suggesting that this treatment induced tissue damage. ALT activity was increased from 287.28 ± 0.29 to 315.98 ± 0.34 U/g in the liver but remained unchanged in serum, whereas the GGT activity was not affected by bullfrog oil treatment. Therefore, despite the interesting modulation of fatty acids by bullfrog oil, a possible therapeutic use requires care since some adverse effects were observed in liver.

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confidence: 93%

“…AST, ALT, GGT, and ALP activities serve as biomarkers of liver injury (20). It is generally assumed that an increase of these enzyme activities reflects active inflammation and necrosis of hepatic cells, whereas a decrease indicates a decline of hepatic inflammation and may lead to morphological improvement (20).…”

mentioning

confidence: 99%

Effect of bullfrog (Rana catesbeiana) oil administered by gavage on the fatty acid composition and oxidative stress of mouse liver

Silva

Miyasaka

Martins

et al. 2004

Braz J Med Biol Res

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“…Sulfur-containing amino acids such as methionine, cystine, taurine, and glutathione have been studied extensively for their antioxidant properties (Parcell 2002;Atmaca 2004;Battin and Brumaghim 2009). Hwang et al (2000) fed 5% taurine to rats and observed decreased liver lipid oxidation from feeding diets containing 3% oxidised fish oil, which indicated that taurine may protect against lipid oxidation. Sulfur in water and feed exists in the form of sulfate; in ruminants, sulfate-reducing bacteria reduce sulfate to hydrogen sulfide, which is utilised to produce sulfur-containing amino acids (Drewnoski et al 2014).…”

Section: Lipid Oxidationmentioning

confidence: 99%

Feeding wet distillers grains plus solubles contributes to sarcoplasmic reticulum membrane instability

et al. 2018

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Abstract. Feeding wet distillers grains plus solubles (WDGS) increases polyunsaturated fatty acid (PUFA) levels in beef. It was hypothesised that WDGS in feedlot diets increases PUFA concentration in the sarcoplasmic reticulum (SR) membrane, thereby altering membrane integrity, resulting in more rapid intracellular calcium leakage and improved tenderness. The objective of this study was to evaluate this hypothesis. Ninety-six crossbred steers were fed either a corn-based diet with 0% WDGS or 50% WDGS. Fifteen strip loins per treatment were collected, fabricated into steaks, aged and placed under retail display conditions. Steaks were used to measure tenderness, proteolysis, free calcium concentrations, lipid oxidation, sarcomere length and SR membrane fatty acid, phospholipid lipid, neutral lipid and total lipid profiles. Compared with steaks from steers fed 0% WDGS, steaks from steers fed 50% WDGS were more tender (P < 0.05) and had greater (P < 0.05) free calcium concentrations early post-mortem. Feeding 50% WDGS also tended to increase (P < 0.10) total PUFA concentrations, decrease (P < 0.10) total phospholipid concentration and increase (P < 0.10) total neutral lipid concentration for SR membrane. Steaks from steers fed 0% WDGS had greater (P < 0.05) lipid oxidation (TBARS values) than steaks from steers fed 50% WDGS after extended aging. Although differences in tenderness between the two treatments were detected, there were no corresponding differences (P > 0.10) in sarcomere length or proteolysis. This study showed that feeding WDGS may increase tenderness, possibly by increasing free calcium in muscle early post-mortem. However, the true mechanism that contributes to these differences is still unclear.

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“…In Japan, meals eaten away from home often include deep-fried foods. The batter coating of breaded pork cutlet (80 g pork), a Japanese favorite, contains [10][11][12][13][14][15] oil 3) , mostly frying oil, which matches the average amount of edible oil ingested daily by the Japanese 2) . Our study 3) revealed that frying oil deteriorated to an extent equal to or greater than that of used frying oil recovered from foodmanufacturing companies was present in 4-56% of commercially deep-fried foods, depending on the analytical items (color, triacylglycerol content, acid value (AV), content of polar compounds, and carbonyl value (COV)).…”

Section: Introductionmentioning

confidence: 99%

“…The rats, probably 4 weeks old, seem too young for the purpose of the experiment, and the oil employed was basically different in properties from oil practically used. Although AST and ALT are important factors for the diagnosis of liver and kidneys, only a few animal studies on the toxicity of oxidized oil measured AST/ALT 11,12) . Recently, a statistical study on life-style related diseases reported that the intake of polar compounds (PC) in cooking oil induced a risk of hypertension 13) .…”

Section: Introductionmentioning

confidence: 99%

Mild Ingestion of Used Frying Oil Damages Hepatic and Renal Cells in Wistar Rats

Totani

Ojiri

2007

J. Oleo Sci.

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Male Wistar rats were fed ad libitum a powdered diet (AIN93G; no fat) containing 7 wt% of fresh oil (control) or used frying oil recovered from Japanese food manufacturing companies (recovered oil) for 12 weeks and subjected to anthropometric measurements, hematological analyses, and observations of the liver and kidneys. All of the rats grew well, and no gross symptoms attributable to recovered oil were observed. There was a tendency toward higher consumption of the diet in the experimental group as compared to the control group. In the serum of the experimental group, no difference was detected in the levels of glucose, triacylglycerol, and phospholipids. But many dark-red patches, necrosis, and bleeding were found in the livers of 75% of the experimental rats; these rats had extremely high aspartate aminotransferase (AST) and alanine aminotransferase (ALT) values. Average AST and ALT values of the experimental group were significantly higher than those of the controls. The renal cells were also obviously damaged. These results raise the concern that frying oil contained in ready-made foods, snacks, etc., if deteriorated to an extent equal to or greater than that of the recovered oil, may be able to change human serum AST/ALT levels and damage the liver and kidneys.

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Effect of taurine on toxicity of oxidized fish oil in rats

Cited by 36 publications

References 14 publications

Effect of bullfrog (Rana catesbeiana) oil administered by gavage on the fatty acid composition and oxidative stress of mouse liver

Effect of bullfrog (Rana catesbeiana) oil administered by gavage on the fatty acid composition and oxidative stress of mouse liver

Feeding wet distillers grains plus solubles contributes to sarcoplasmic reticulum membrane instability

Mild Ingestion of Used Frying Oil Damages Hepatic and Renal Cells in Wistar Rats

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