Abstract:Human growth hormone (somatropin) is one of the most widely used recombinant proteins that stimulates growth, cell reproduction, and cell regulation in humans. Synthetic production of this protein normally results in low yields and inclusion body formation. To overcome these difficulties, the production of somatropin along with two common signal peptides, namely TorA and SufI, in co-expression with a cytosolic chaperone, GroEL/ES, was evaluated in the present study. The target protein and the two signal sequen… Show more
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