Effect of tannic acid on blood components and functions

Deng, Lu; Qi, Yanfang; Liu, Zonghua; Xi, Yun; Wang, Xue

doi:10.1016/j.colsurfb.2019.110505

Cited by 37 publications

(36 citation statements)

References 33 publications

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“…The clotting mechanism is assumed to be triggered in two different ways, (a) interaction with negatively‐charged materials such as polyphenols, kaolin, and silica, which is called endogenous coagulation and (b) interaction with materials containing tissue thromboplastins, which is called exogenous coagulation. Deng et al indicated that polyphenolics seriously affect the exogenous coagulation mechanism at low concentrations, but endogenous coagulation can be triggered at high concentration of phenolics in the blood 40 . Our results show that p(CAT) particles lead to endogenous coagulation at ≥25 μg/ml of particle concentrations because of the highly negatively charged nature of p(CAT) particles.…”

Section: Resultsmentioning

confidence: 57%

“…Deng et al indicated that polyphenolics seriously affect the exogenous coagulation mechanism at low concentrations, but endogenous coagulation can be triggered at high concentration of phenolics in the blood. 40 Our results show that p(CAT) particles lead to endogenous coagulation at ≥25 μg/ml of particle concentrations because of the highly negatively charged nature of p(CAT) particles. These blood compatibility tests indicate that p(CAT) particles can be safely used up to 10 μg/ml concentration in the vascular system.…”

Section: Resultsmentioning

confidence: 69%

“…The possible red blood cell destroying mechanism of polyphenolics was speculated. The small molecules of polyphenolics can readily interact with the cells by means of intermolecular hydrogen bonds and may cause to cells rupture when adsorbed onto the surface of the cell membrane with hydrophilic phenolic hydroxyl groups 40 . So, it is clear that the hemolytic effect of CAT can be diminished in particle formulation, and can be attributed to the larger size as well as structural changes due to the existence of crosslink units.…”

Section: Resultsmentioning

confidence: 99%

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A polyphenolic biomacromolecule prepared from a flavonoid: Catechin as degradable microparticles

Suner

Mohapatra

Ayyala

et al. 2021

J of Applied Polymer Sci

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Catechin (CAT) was crosslinked with trimethylolpropane triglycidyl ether (TMPTGE) to obtain degradable poly(CAT) particles in a single step. Spherical p(CAT) particles with tens of micrometer size range and an isoelectronic point at pH 1.2 were obtained. The hydrolytic degradation of p(CAT) particles provided sustainable and extended release with 264 mg/g CAT release within 10 days at pH 7.4. The antioxidant capacity of 55.0 ± 0.9 μg/ml gallic acid equivalent in terms of total phenol content, and 0.88 ± 0.3 μmol/g trolox equivalent were estimated for p(CAT) particles displaying strong radical scavenging capability. Blood clotting and hemolysis assays demonstrated dose-dependent blood compatibility revealing higher blood compatibility for p(CAT) particles up to 10 μg/ml concentration. The cytotoxicity results show that p(CAT) particles have almost no toxicity for CCD841 normal colon cells at 250 μg/ml concentration in 24 h incubation time giving~97% cell viability, whereas CAT molecules only provide~34% cell viability.

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Section: Resultsmentioning

confidence: 57%

Section: Resultsmentioning

confidence: 69%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

A polyphenolic biomacromolecule prepared from a flavonoid: Catechin as degradable microparticles

Suner

Mohapatra

Ayyala

et al. 2021

J of Applied Polymer Sci

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“…Fibrinogen is a well-known protein in the blood which plays a significant role in coagulation of blood. Phenolic compounds can interact with some proteins like fibrinogen and may affect their biological functions [20]. Therefore, the fibrinogen interaction effects of RUT and p(RUT) microgel/ nanogel were investigated to find the blood compatibility of materials.…”

Section: Resultsmentioning

confidence: 99%

“…The effects of RUT and p(RUT) microgel/nanogel on the fluorescence properties of fibrinogen were demonstrated with fluorescence spectroscopy (Thermo Scientific Lumina Spectrophotometer) according to the literature [20]. Different concentrations of RUT or p(RUT) micro/ nanogel, 16-250 µg/mL in PBS, were mixed with fibrinogen solution in 1:1 ratio by volume.…”

Section: Fibrinogen Interaction Of Rut and P(rut) Microgel/nanogelmentioning

confidence: 99%

Poli(Rutin) micro/nanogels for biomedical applications

Şahiner¹,

Suner²

2021

Hittite J. Sci. Eng.

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I nterest in flavonoids, which are phenolic compounds, has grown with the French paradox. Interest in bioflavonoids has increased based on Mediterranean culture, which includes a diet rich in phenol directly proportional to high fat with an inverse relationship with the risk of heart attack. Flavonoids are widely used in the food industry due to antioxidant and antimicrobial properties. Flavonoids are known to affect many biofunctions such as lowering blood pressure and having anti-inflammatory, hypocholesterolemic, anticancer platelet stabilizer, antiallergic, antidepressant and blood clotting properties [1,2]. Rutin is a known flavonoid and has two sugar molecules in its structure. Rutin's chemical name is quercetin-3-remnosyl glucoside [3]. It is present in many fruits and vegetables such as onion, tea, apple, parsley, citrus, sage, and grape [4]. It is used in the food, cosmetics, and even pharmacology industries

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Nature‐Inspired Gelatin‐Based Adhesive Hydrogel: A Rapid and User‐Friendly Solution for Hemostatic Applications

Wang,

et al. 2024

Adv Healthcare Materials

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Conventional hemostatic agents face challenges in achieving rapid hemostasis and effective tissue repair due to limited hemostatic scenarios, suboptimal efficacy, and inadequate adhesion to wet tissues. Drawing inspiration from nature‐sourced materials, we designed a gelatin‐based adhesive hydrogel (AOT), easily prepared and quick to form, driven by Schiff base and multiple hydrogen bonds for applications in arterial and liver bleeding models. AOT exhibited exceptional adhesion to wet tissues (48.67 ± 0.16 kPa) and displays superior hemostatic properties with reduced blood loss and hemostatic time compared to other hydrogels and conventional hemostatic materials. Moreover, AOT hydrogel exhibited good biocompatibility and biodegradability. In summary, this easily prepared adhesisve hydrogel has the potential to supplant traditional hemostatic agents, offering a novel approach to achieve swift sealing of hemostasis and facilitate wound healing and repair in broader application scenarios, owing to its unique advantages.This article is protected by copyright. All rights reserved

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Effect of tannic acid on blood components and functions

Cited by 37 publications

References 33 publications

A polyphenolic biomacromolecule prepared from a flavonoid: Catechin as degradable microparticles

A polyphenolic biomacromolecule prepared from a flavonoid: Catechin as degradable microparticles

Poli(Rutin) micro/nanogels for biomedical applications

Nature‐Inspired Gelatin‐Based Adhesive Hydrogel: A Rapid and User‐Friendly Solution for Hemostatic Applications

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