Effect of Tandospirone on Sleep Latency in Rats Placed on a Grid Suspended Over Water

Abstract

Abstract. The present study was performed to examine the effect of tandospirone on sleep latency in a new insomnia animal model by placing rats on a grid suspended over water. For investigating the mechanism of tandospirone, the effect of tandospirone on sleep latency was also studied using rats that were depleted with neuronal serotonin (5-HT) after p-chlorophenylalanine administration. Tandospirone caused a shortening of sleep latency dose-dependently, and a significant effect was observed at 20 mg / kg, p.o. or more. A shortening of sleep latency was observed by administration of p-chlorophenylalanine (300 mg / kg, i.p.) for 2 days. On the other hand, tandospirone exerted no potentiating effect on the shortening of sleep latency induced by p-chlorophenylalanine. From these findings, a shortening of sleep latency induced by tandospirone may occur through the pre-synaptic 5-HT 1A receptors in rats.

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“…26,27) As shown in the present data, however, tandospirone increased non-REM sleep time in rats treated with ACTH. This difference may be due to upregulation of 5-HT 2A receptors in ACTH-treated rats.…”

Studies on Somnolence in the Daytime Caused by Drugs Used for Neuropathic Pain

“…2.0, according to the criteria previously described (13,14). As a final step, the defined sleepwake stages were examined visually, and corrected if…”