Effect of Tamsulosin on Stentrelated Symptoms; A Prospective Study

Abstract

ORIGINAL PROF-3254 ABSTRACT… Introduction: Cystoscopic intraluminal placement of ureteral stents has become a routine practice in urology. Ureteral stents preserve urine flow from the kidney to the bladder in cases of ureteral obstruction (intrinsic or extrincis). In patients with obvious ureteral obstruction, the placement of a ureteral stent will restart urine transport and protect the kidney from possible risks. Ureteral stents are troublesome in some patients and causes LUTS. Study Design: Prospective randomized controlled trial. Setting: Urology Department, Sheikh Zayed Hospital Lahore. Period: Six month started from August 2015 to December 2015. Material and Methods: 100 patients who were randomly divided into two equal groups. The patients were between 18 to 50 years of age of both gender undergo retrograde double-J ureteral stent placement. Before the double-J stent will be applied, all patients completed an International Prostate Symptom Score (IPSS) questionnaire for evaluation of lower urinary tract symptoms. Patients were divided in two groups on the basis of lottery method tamsolusin group (1) and placebo group (2). Tamsulosin group patients was given tamsulosin post operatively and placebo group was given a placebo postoperatively. Results: There were total 100 patients who were enrolled in this study with a mean age of 42.63±6.24. There were 75(75%) were male while 25(25%) were female. The mean IPSS sore at presentation was 2.47±1.43 and post treatment was 5.20±1.65. There was significant difference in IPSS score in control group with mean 5.28±1.69 versus study as mean 2.22±1.05 group, p-value= 0.010. Conclusion: There is difference in lowering of IPSS score in the patients who are given tamsolusin versus those who were retained on placebo.

The efficacy of adjunctive alpha-blockers on ureteroscopy procedure for ureteral stones: a systematic review and meta-analysis

“…Postoperative complications outcome is also affected by the administration of postoperative alpha-blockers 19 , 20 . It was found that endoscopic treatments without the administration of adjunctive alpha-blockers are associated with a higher probability of complications 2 , 21 .…”

The efficacy of adjunctive alpha-blockers on ureteroscopy procedure for ureteral stones: a systematic review and meta-analysis

“…15,18 Postoperative complications outcome is also affected by the administration of postoperative alpha-blockers. 19,20 It was found that endoscopic treatments without the administration of adjunctive alpha-blockers are associated with a higher probability of complications. 2,21 This was shown by the forest plot, where the adjunctive alpha-blocker gives a protective effect from postoperative complications with RR = 0.41 (95% CI, 0.27-0.61).…”

A clinical study of effects of tamsulosin in ureteric stent related morbidity

“…In group A at baseline the mean of IPSS score was 9.17 (SD 1.53), the QoL score was 2.1 (SD 0.86) and Total IPSS + QoL questionnaire score 11.28(SD 1.6), but at stent removal the mean scores were 14.41 (SD 3.34) for IPSS, and 2.76 (SD 1.12) for QoL score and Total IPSS + QoL questionnaire score 17.24 (SD 3.25) 9. The findings of other study are similar to our study.…”

“…2,6 Alpha adrenergic receptor like α1A and α1D have been documented to be distributed the in the lower urinary tract and the distal ureter and the use of alpha adrenergic receptor blockers like Tamsulosin have shown considerable promise in treating the stent related symptoms. [7][8][9] This study, was done in an effort to determine the effect of tamsulosin in improving double-J stent related symptoms and QoL following ureteral stent placement.…”