Effect of Tadalafil on prostate haemodynamics: preliminary evaluation with contrast-enhanced US

Bertolotto, Michele; Trincia, Elena; Zappetti, Roberta; Bernich, R.; Savoca, G.; Cova, Maria Assunta

doi:10.1007/s11547-009-0449-8

Cited by 41 publications

(30 citation statements)

References 25 publications

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“…[10][11][12] PDE5 inhibitors acts by upregulation of the NO/cGMP activity. Preclinical studies reported partial reversal of nor-epinephrine-and endothelin-1-reduced prostatic tissue contraction 13 and an anti-proliferative effect on cultured prostate and bladder smooth muscle cells 14 . These mechanisms may decrease smooth muscle tension in the prostatic stroma and capsule and attenuate cellular proliferation associated with prostate/bladder hypertrophy respectively.…”

Section: Discussionmentioning

confidence: 99%

Comparative Study of Tadalafil and Tamsulosin as on therapy For Lower Urinary Tract Symptoms Due To Benign Hyperplasia of Prostate.

Pawar¹,

Kumar²,

Singh³

et al. 2016

IOSR

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Section: Discussionmentioning

confidence: 99%

Comparative Study of Tadalafil and Tamsulosin as on therapy For Lower Urinary Tract Symptoms Due To Benign Hyperplasia of Prostate.

Pawar¹,

Kumar²,

Singh³

et al. 2016

IOSR

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“…As a result there is decrease in smooth muscle tension in the prostatic stroma and capsule and also attenuate cellular proliferation associated with prostate/bladder neck hypertrophy respectively. Tadalafil had shown improved blood flow to prostate on color doppler ultrasound 15 .…”

Section: Discussionmentioning

confidence: 99%

Comparative Study of Tadalafil And Tamsulosin in Benign Hyperplasia of Prostate For Lower Urinary Tract Symptoms (LUTS)

Balaji¹,

Mukhilesh²

2017

IOSR JDMS

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“…Recent studies have demonstrated that PDE5 inhibitors can improve lower urinary tract symptoms (LUTS) and urodynamic parameters [3,4,5]. These indications may be sufficient to convince physicians to prescribe PDE5 inhibitors once daily to patients with erectile dysfunction (ED) with or without concomitant LUTS.…”

Section: Introductionmentioning

confidence: 99%

Impact of the Change in Urinary and Sexual Function on Health-Related Quality of Life after Once Daily Low-Dose Mirodenafil Treatment in Patients with Organic Erectile Dysfunction

Lee

Choe²,

Kim³

et al. 2014

Urol Int

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Objective: We aimed to evaluate whether changes in urinary and sexual function can influence health-related quality of life. Patients and Methods: Out of 54 recruited patients, 36 were enrolled, and data for 30 participants with erectile dysfunction were available. At baseline and after 1 and 2 months, each participant completed the International Index of Erectile Function (IIEF-15), the International Prostate Symptom Score (IPSS) and the Medical Outcomes Study Short-Form 36-Item Health Survey (SF-36). Uroflowmetry, post-voiding residual volume and the nocturnal penile tumescence (NPT) test were performed at baseline and at the study's conclusion. Results: Compared with baseline, the IPSS, IIEF-15, peak urinary flow rate, NPT parameters and mental component of the SF-36 exhibited significant improvement at the study's conclusion. Among the symptomatic parameters, the changes in the storage and erectile function parameters contributed significantly to the change in the mental component score on the SF-36 (p = 0.007, R² = 0.502). Conclusions: The daily administration of low-dose mirodenafil (50 mg) produced improvements in urinary and erectile function with or without sexual stimulation. Furthermore, this therapy enhanced the mental component of health-related quality of life by improving storage and erectile symptoms.

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Effect of Tadalafil on prostate haemodynamics: preliminary evaluation with contrast-enhanced US

Abstract: In patients with BPH, vascular changes are observed in the prostate after Tadalafil administration, which can be detected with CEUS.

Cited by 41 publications

References 25 publications

Comparative Study of Tadalafil and Tamsulosin as on therapy For Lower Urinary Tract Symptoms Due To Benign Hyperplasia of Prostate.

Comparative Study of Tadalafil and Tamsulosin as on therapy For Lower Urinary Tract Symptoms Due To Benign Hyperplasia of Prostate.

Comparative Study of Tadalafil And Tamsulosin in Benign Hyperplasia of Prostate For Lower Urinary Tract Symptoms (LUTS)

Impact of the Change in Urinary and Sexual Function on Health-Related Quality of Life after Once Daily Low-Dose Mirodenafil Treatment in Patients with Organic Erectile Dysfunction

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