Effect of tadalafil combined with atorvastatin on hemodynamics and sexual function in middle-aged and elderly patients with hyperlipidemia complicated with erectile dysfunction

Abstract

Objective: To evaluate the effect and clinical significance of tadalafil combined with atorvastatin on hemodynamics and sexual function in middle-aged and elderly patients with hyperlipidemia complicated with Erectile dysfunction (ED).
 Methods: Eighty patients with hyperlipidemia complicated with ED who were treated at The Second Hospital of Hebei Medical University from January 2019 to June 2020 were selected. Using a completely randomized design experimental method, these 80 patients were randomly divided into two groups: the experimental group and the control group, with 40 cases in each group. The control group was treated with a single drug, atorvastatin calcium, while the experimental group was given tadalafil orally on the basis of the control group for 3 months. Changes in the levels of inflammatory factors such as IL-6, TNF and CRP, adverse drug reactions, changes in hemodynamic indicators such as HSV, LSV, PSV, HCT and ESR before and after treatment, as well as changes in sexual function after treatment were compared and analyzed between the two groups.
 Results: TNF-a, CRP and IL-6 in the experimental group were significantly lower than those in the control group after treatment, with statistically significant differences (p<0.05). There was no significant difference in the incidence of adverse drug reactions between the two groups (p=0.18). After treatment, hemodynamic indexes and sexual function indexes of the experimental group were significantly improved compared with those in the control group, with statistically significant differences (p<0.05).
 Conclusion: A significant improvement effect can be achieved by tadalafil combined with atorvastatin on hemodynamics and sexual function in middle-aged and elderly patients with hyperlipidemia complicated with ED. At the same time, the combination of the two has synergism on inflammatory factors and blood rheology, and the incidence of adverse reactions is not significantly increased.
 Abbreviations: ED: Erectile dysfunction, PDE-5: Phosphodiesterase-5, IL-6: Interleukin- 6, CRP: C-reactionprotein, HSV: High shear viscosity, LSV: Low cut viscosity of whole blood, PSV: The plasma viscosity, HCT: Hematocrit, ESR: Erythrocyte sedimentation rate, IIEF-5: International Index of Erectile Function Questionnaire – 5, HMG-CoA: Hydroxy-methylglutaryl coenzyme A, cGMP: cyclic Guanosinc monophosphate, TNF-α: Tumor necrosis factor-α, IFN-γ: Interferon-γ, TC: Total cholesterol, TG: Triglycerides, HDL-C: High density lipoprotein cholesterol.
 doi: https://doi.org/10.12669/pjms.37.7.4257
 How to cite this:Du L, Jia J, Xue W, Qi J. Effect of tadalafil combined with atorvastatin on hemodynamics and sexual function in middle-aged and elderly patients with hyperlipidemia complicated with erectile dysfunction. Pak J Med Sci. 2021;37(7):---------. doi: https://doi.org/10.12669/pjms.37.7.4257
 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Impact of atorvastatin on erectile dysfunction: A meta‐analysis and systematic review

“…Three hundred and seventy‐eight related studies were found from all databases, and 9 studies were finally included in this meta‐analysis after subsequent screenings (Bank et al, 2006; Dadkhah et al, 2010; Doğru et al, 2008; Du et al, 2021; El‐Sisi et al, 2013; Gokce et al, 2012; Gokkaya et al, 2008; Herrmann et al, 2006; Nurkalem et al, 2014). Figure 1 depicts the method of screening the literature.…”

“…Seven of the nine selected papers were RCTs (Bank et al, 2006; Dadkhah et al, 2010; Du et al, 2021; El‐Sisi et al, 2013; Gokce et al, 2012; Herrmann et al, 2006; Nurkalem et al, 2014) and two were non‐randomized studies (Doğru et al, 2008; Gokkaya et al, 2008). 332 patients received an atorvastatin treatment, 141 patients received a placebo treatment, 44 patients received a rosuvastatin treatment and 40 patients received a combination of atorvastatin and tadalafil treatment.…”

“…In a meta‐analysis based on SATs, 9 Studies (Bank et al, 2006; Dadkhah et al, 2010; Doğru et al, 2008; Du et al, 2021; El‐Sisi et al, 2013; Gokce et al, 2012; Gokkaya et al, 2008; Herrmann et al, 2006; Nurkalem et al, 2014) were included in the review. We only included the group treated with atorvastatin alone in 9 trials with different groups of treatments for SAT meta‐analysis.…”

Tadalafil versus pentoxifylline in the management of diabetic kidney disease: a randomized clinical trial

“…Animal studies as well as many clinical trials reported that TAD has different beneficial effects in multiple diseases regarding hyperglycemia [ 24 ], inflammation [ 25 ], oxidative stress [ 26 ] and endothelial dysfunction [ 27 ] that make it a target in treatment or at least as adjuvant therapy for multiple diseases. PTX has recently reported various beneficial effects on the kidneys directly [ 28 ].…”