2003
DOI: 10.1021/ie020577k
|View full text |Cite
|
Sign up to set email alerts
|

Effect of Tablet Deflectors in the Draft Tube of Fluidized/Spouted Bed Coaters

Abstract: The control of tablet-to-tablet variation that occurs during batch coating operations is important in the pharmaceutical industry. This is particularly true when the coating substance contains an active ingredient (drug). The current work focused on evaluating the effect of tablet deflectors in the spray zone on the variation of coating material received by individual tablets as they pass through the spray. Digital video imaging was used to show how these deflectors changed the solids' velocity and voidage pro… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

0
11
0

Year Published

2005
2005
2023
2023

Publication Types

Select...
8
1

Relationship

0
9

Authors

Journals

citations
Cited by 20 publications
(11 citation statements)
references
References 14 publications
(28 reference statements)
0
11
0
Order By: Relevance
“…Compared with the fluidized bed, a spouted bed has several advantages, such as high efficiency of gas−solid contact, big capacity for handling a coarse particle, stable operation in a wide range of gas flow rates, small pressure drop, and little fluidizing air flow rate, etc. However, due to several limitations of the conventional spouted bed (CSB), such as low annulus aeration and slow solids turnover, which is one of the reasons for the limited commercial use of spouted bed, the particles in the bed have a long residence time and poor efficiency of heat and mass transfer. Since the conventional spouted bed suffers from these shortcomings, many modified spouted bed designs have been proposed during the past decades, for example, multiple spouted beds, spouted fluidized beds, , conical spouted beds, draft tube spouted bed, pulsed spouted bed, and rotating spouted bed. ,, Moreover, the particle hydrodynamic characteristics and gas−solid reaction models in these spouted beds have been studied. Lefroy and Davidson reported the dynamic behavior of the gas phase and solid phase in a spouted bed using a gas−solid flow model .…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…Compared with the fluidized bed, a spouted bed has several advantages, such as high efficiency of gas−solid contact, big capacity for handling a coarse particle, stable operation in a wide range of gas flow rates, small pressure drop, and little fluidizing air flow rate, etc. However, due to several limitations of the conventional spouted bed (CSB), such as low annulus aeration and slow solids turnover, which is one of the reasons for the limited commercial use of spouted bed, the particles in the bed have a long residence time and poor efficiency of heat and mass transfer. Since the conventional spouted bed suffers from these shortcomings, many modified spouted bed designs have been proposed during the past decades, for example, multiple spouted beds, spouted fluidized beds, , conical spouted beds, draft tube spouted bed, pulsed spouted bed, and rotating spouted bed. ,, Moreover, the particle hydrodynamic characteristics and gas−solid reaction models in these spouted beds have been studied. Lefroy and Davidson reported the dynamic behavior of the gas phase and solid phase in a spouted bed using a gas−solid flow model .…”
Section: Introductionmentioning
confidence: 99%
“…[1][2][3][4][5][6][7][8][9][10][11][12] However, due to several limitations of the conventional spouted bed (CSB), such as low annulus aeration and slow solids turnover, which is one of the reasons for the limited commercial use of spouted bed, 13 the particles in the bed have a long residence time and poor efficiency of heat and mass transfer. Since the conventional spouted bed suffers from these shortcomings, many modified spouted bed designs have been proposed during the past decades, 14 for example, multiple spouted beds, [15][16][17] spouted fluidized beds, 18,19 conical spouted beds, [20][21][22] draft tube spouted bed, [23][24][25][26][27] pulsed spouted bed, 13 and rotating spouted bed. 14,28,29 Moreover, the particle hydrodynamic characteristics and gas-solid reaction models in these spouted beds have been studied.…”
Section: Introductionmentioning
confidence: 99%
“…Spouted-bed dryers also have been used for the coating of particles to obtain products with special properties. A special area of application for this type of equipment in the pharmaceutical industry is the coating of tablets , and other functional particles, such as those used, for example, as injectable suspensions for cancer therapy . Drying is one of the stages that appears in all of the aforementioned technologies, and, in many cases, it limits the rate of process.…”
Section: Introductionmentioning
confidence: 99%
“…Spouted beds have developed as efficient fluid-particle contactors and have found numerous applications in the industry. Applications range from coal combustion and gasification (3)(4)(5), combustion of other fuels (6), catalytic reactors (7), thermal processing of solids (8), mixing of solids (9), and coating of particles (10) to drying of suspensions and pastes on inert solids (11)(12)(13), in addition to a variety of chemical reactions involving multiphase systems (14)(15)(16).…”
Section: Introductionmentioning
confidence: 99%