Effect of systemic blood pressure on optical coherence tomography angiography in glaucoma patients

Park, Chan Keum; Lee, Kwanghyun; Kim, Eun Woo; Kim, Sangah; Kim, Chan Yun; Seong, Gong Je; Bae, Hyoung Won

doi:10.1038/s41433-020-01199-x

Cited by 9 publications

(5 citation statements)

References 60 publications

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“…Most studies implied that age is an important factor associated with macular VD and PD [ 28 , 32 – 36 ]. This was consistent with the results of this study.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of macular microvascular density using optical coherence tomography angiography in patients with Posner-Schlossman syndrome

et al. 2022

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Background Optical coherence tomography angiography (OCTA) is a novel technology that provides a noninvasive, dye-less method to visualize the blood vessels of the retina. In the present study, we investigate macular microvascular density and the correlation of ocular and demographic factors using OCTA in Posner-Schlossman syndrome (PSS) patients. Methods This is a prospective observational study. All PSS patients and age- and sex-matched healthy subjects underwent complete ophthalmologic examination, and RE, BCVA, IOP, CCT, AL, CMT, GCIPI, RNFL, C/D ratio were recorded. The whole-image vessel density (wiVD) and whole-image perfusion density (wiPD), three-circle (1 mm central ring, 3 mm inner ring, 6 mm outer ring), and four-quadrant segmental VD and PD were calculated. Results Seventeen PSS patients and 17 healthy subjects were enrolled in this study. The mean age was 42.65 ± 11.22 years in PSS patients and 42.71 ± 10.50 years in healthy controls. IOP, CCT, and C/D ratio were higher in PSS-attacked eyes, and BCVA, OPP and RNFL thickness was lower than those in the fellow eyes (p < 0.05). BCVA and OPP were improved in the PSS-attacked eyes in intermittent period (p < 0.05). The wiVD and wiPD were lower in the PSS-affected eyes than in the fellow eyes and in the control eyes in the PSS-attacked period (p < 0.05). All segmental VD and PD was lower in the PSS affected eyes than in the healthy control eyes (p < 0.05). In intermittent period, the wiVD and wiPD were lower in the PSS-affected eyes than in the fellow eyes (p < 0.05). Age, CCT, and SSI were associated with macular wiVD and wiPD in PSS attacked period. Age and CCT were associated with macular wiVD and wiPD in PSS intermittent period. Conclusion Decreased macular superficial VD and PD was found in patients with Posner-Schlossman syndrome in attacked period and in remission. Macular wiVD and wiPD were associated with age, CCT and SSI in PSS patients.

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“…Most studies implied that age is an important factor associated with macular VD and PD [ 28 , 32 – 36 ]. This was consistent with the results of this study.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of macular microvascular density using optical coherence tomography angiography in patients with Posner-Schlossman syndrome

et al. 2022

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“…Glaucomatous eyes with disc hemorrhage tended to show microvascular dropout or VD reduction on OCT-A 22 , 31 . According to other OCT-A studies, systemic conditions such as nocturnal BP dip, higher systemic BP or low arterial BP were associated with reduced ocular VD 27 , 28 . These all indicate disturbances or instability of systemic or local blood flow, as capsured by OCT-A, and this tool could be promising in terms of evaluating the vascular status of the retina or ONH in glaucoma.…”

Section: Discussionmentioning

confidence: 82%

“…Dips in nocturnal BP have been reported to be associated with localized choroidal VD loss in glaucoma patients 27 . Furthermore, glaucoma patients with higher systemic BP showed reducted macular VD 28 . These studies could help us determine the relationship between systemic conditions and blood flow to the ONH or to the retina and help us understand the pathophysiology of progression in glaucoma.…”

Section: Introductionmentioning

confidence: 91%

Association of choroidal blood flow with autonomic dysfunction in patients with normal tension glaucoma

Shin

Hong

Lee

et al. 2022

Sci Rep

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There is increasing evidence that autonomic dysfunction is an important factor in the progression of glaucoma. Mechanism of the association between autonomic dysfunction and progression of glaucoma is poorly understood. Since blood circulation is basically regulated by the autonomic nervous system, autonomic dysfunction may contribute to unstable or fluctuating blood pressure. Therefore, It is hypothesized that autonomic dysfunction may contribute to impaired ocular blood flow and lead to glaucoma progression. However, no clinical study yet has evaluated the relationship between ocular blood flow and autonomic nervous function. We enrolled 152 open angle glaucoma patient. Ocular blood flow was assessed by measuring vessel density (VD) using optical coherence tomography angiography, and autonomic nervous function was evaluated with heart-rate variability (HRV) parameters. The low frequency/high frequency (LF/HF) ratio, which is one of the HRV parameters, quantified the degree of sympathovagal balance. This indicator could represent autonomic dysfunction. Higher LF/HF ratio was associated with reduction of the deep parapapillary VD (R = − 0.243, P = 0.003). Linear regression analysis showed a significant negative association between parapapillary choroidal VD and LF/HF ratio (β = − 0.249; 95% confidential interval = − 1.193 to − 0.249; P = 0.002) in multivariate analysis. We demonstarted the association between impaired ocular blood flow (parapapillary choroidal vessel density) and autonomic dysfunction (LF/HF ratio). This study could help understand the role of the autonomic dysfunction in pathophysiology of glaucoma progression.

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“…Three patients were treated for arterial systemic hypertension and their systemic medication did not change during the study, but arterial blood pressure was not measured. Park and co-workers [ 67 ] reported that in glaucomatous eyes with an optic disc hemorrhage, high systemic blood pressure was associated with a reduction in macular VD. However, none of our patients had an optic disc hemorrhage at baseline or after 3 months of treatment with latanoprost.…”

Section: Discussionmentioning

confidence: 99%

Retinal Ganglion Cell Function and Perfusion following Intraocular Pressure Reduction with Preservative-Free Latanoprost in Patients with Glaucoma and Ocular Hypertension

Daka,

Sustar Habjan,

Meglič

et al. 2024

JCM

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(1) Background: Given the global prevalence of glaucoma and the crucial role of intraocular pressure (IOP) reduction in the management of the disease, understanding the immediate effects on retinal structure and function is essential. (2) Methods: This study aimed to assess the effects of preservative-free latanoprost on morphological and functional parameters in treatment-naïve patients with ocular hypertension and open-angle glaucoma. (3) Results: This study showed a significant reduction in IOP by an average of 30.6% after treatment with preservative-free latanoprost. Despite the significant reduction in IOP, no statistically significant changes were observed in the electroretinogram (ERG) nor the optical coherence tomography/angiography (OCT/OCTA) parameters compared to baseline. An exploration of the correlation between IOP changes and various parameters revealed a significant association solely with the macular IPL/INL plexus vessel density (VD) measured with OCTA. (4) Conclusions: This finding suggests a possible association between IOP reduction and changes in the macular microcirculation and provides valuable insights into the differential effects of latanoprost. Acknowledging the study limitations, this study emphasizes the need for larger, longer-term investigations to comprehensively assess the sustained effects of preservative-free latanoprost on both IOP and retinal parameters. In addition, exploring systemic factors and conducting subgroup analyses could improve personalized approaches to glaucoma treatment.

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Effect of systemic blood pressure on optical coherence tomography angiography in glaucoma patients

Cited by 9 publications

References 60 publications

Evaluation of macular microvascular density using optical coherence tomography angiography in patients with Posner-Schlossman syndrome

Evaluation of macular microvascular density using optical coherence tomography angiography in patients with Posner-Schlossman syndrome

Association of choroidal blood flow with autonomic dysfunction in patients with normal tension glaucoma

Retinal Ganglion Cell Function and Perfusion following Intraocular Pressure Reduction with Preservative-Free Latanoprost in Patients with Glaucoma and Ocular Hypertension

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