Effect of Synthetic Pyrethroid Pesticide Exposure During Pregnancy on the Growth and Development of Infants

Xue, Zhanyou; Li, Xiaoqiong; Qian, Suyun; Xu, Li; Zhang, Peng; Kong, Zhenyu; Xu, Jinming; Teng, Jun

doi:10.1177/1010539513496267

Cited by 66 publications

(35 citation statements)

References 14 publications

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“…Aside from NHANES, there have been only a few studies in other pregnancy cohorts from around the world that have reported on urinary concentrations for some of these analytes [ 11 – 13 , 30 , 32 , 44 ]. Perhaps most relevant to our findings, in a study of pyrethroid exposures among pregnant women from 10 Caribbean countries (the authors did not include the Commonwealth of Puerto Rico), urinary detection frequencies for data across all countries were between 77-100% for cis -DBCA, trans -DCCA, 3-PBA, and 4-F-3-PBA [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

Urinary biomarkers of exposure to insecticides, herbicides, and one insect repellent among pregnant women in Puerto Rico

et al. 2014

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BackgroundThere are potential adverse health risks to the mother and fetus from exposure to pesticides. Thus, studies of exposure to pesticides among pregnant women are of interest as they will assist with understanding the potential burden of exposure globally, identifying sources of exposure, and designing epidemiology studies.MethodsWe measured urinary concentrations of the insect repellent N-N-diethyl-meta-toluamide (DEET) and two of its metabolites [3-diethyl-carbamoyl benzoic acid (DCBA) and N,N-diethyl-3-hydroxymethylbenzamide (DHMB)], four pyrethroid insecticide metabolites [4-fluoro-3-phenoxybenzoic acid (4-F-3-PBA); 3-phenoxybenzoic acid (3-PBA); trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylic acid (trans-DCCA); and cis-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropane carboxylic acid (cis-DBCA)], and two chlorophenoxy herbicides [2,4-dichlorophenoxyacetic acid (2,4-D) and 2,4,5-trichlorophenoxyacetic acid (2,4,5-T)] in 54 pregnant women from Puerto Rico at three separate time points (20 ± 2 weeks, 24 ± 2 weeks, and 28 ± 2 weeks of gestation). We calculated the distributions of the biomarker concentrations and compared them to those of women of reproductive age from the general U.S. population where available, and estimated the within-subject temporal variability of these repeated measurements. We also collected questionnaire data on demographics, consumption of select fruits, vegetables, and legumes in the past 48-hr, and pest-related issues, and associations between these variables and biomarker concentrations were examined.ResultsWe found that 95th percentile urinary concentrations of DEET, 3-PBA, trans-DCCA, and 2,4-D were lower than women of reproductive age on the U.S. mainland, whereas 95th percentile urinary concentrations of 4-F-3-PBA, cis-DBCA, and 2,4,5-T were similar. DCBA, the only urinary biomarker detected in >50% of the samples, showed fair to good reproducibility across pregnancy (intraclass correlation coefficient: 0.60). Women were more likely (p <0.05) to have greater urinary concentrations of pesticide biomarkers if they were less educated (DCBA and trans-DCCA), unemployed (DHMB), or married (2,4-D), had consumed collards or spinach in past 48-hr (2,4-D) or had been using insect repellent since becoming pregnant (DCBA), or were involved with residential applications of pesticides (trans-DCCA).ConclusionsWe identified concentrations and predictors of several pesticides among pregnant women in Puerto Rico. Further research is needed to understand what aspects of the predictors identified lead to greater exposure, and whether exposure during pregnancy is associated with adverse health.

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Section: Discussionmentioning

confidence: 99%

Urinary biomarkers of exposure to insecticides, herbicides, and one insect repellent among pregnant women in Puerto Rico

et al. 2014

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“…Out of five studies that evaluated the effects of prenatal PI exposure on children’s neurodevelopment, three identified evidence of deleterious outcomes. Xue and collaborators (Xue and others 2013) quantified 3-PBA, a metabolite of permethrin, cypermethrin, deltamethrin, allethrin, resmethrin, fenvalerate, cyhalothrin, fenpropathrin, and tralomethrin, in the urine of pregnant women and reported an inverse association between prenatal PI exposure and measures of motor function, social adaptation, and intelligence in Chinese infants at 1 year of age. As part of the CCCEH study, Horton and collaborators (Horton and others 2011) assessed permethrin in personal air samples collected during pregnancy.…”

Section: Pyrethroids (Pis)mentioning

confidence: 99%

Developmental neurotoxicity of succeeding generations of insecticides

Abreu‐Villaça

Levin

2017

Environment International

124

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Insecticides are by design toxic. They must be toxic to effectively kill target species of insects. Unfortunately, they also have off-target toxic effects that can harm other species, including humans. Developmental neurotoxicity is one of the most prominent off-target toxic risks of insecticides. Over the past seven decades several classes of insecticides have been developed, each with their own mechanisms of effect and toxic side effects. This review covers the developmental neurotoxicity of the succeeding generations of insecticides including organochlorines, organophosphates, pyrethroids, carbamates and neonicotinoids. The goal of new insecticide development is to more effectively kill target species with fewer toxic side effects on non-target species. From the experience with the developmental neurotoxicity caused by the generations of insecticides developed in the past advice is offered how to proceed with future insecticide development to decrease neurotoxic risk.

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“…Despite their less toxic effect to human health, recent research revealed that even low-level exposure to pyrethroids also have adverse effects on not only the nervous system but also other systems in humans. There are some reports about immunologic response associated with exposure to pyrethroid [ 8 , 9 ], behavioral problems in children [ 10 ], and neural and mental development of infants who are exposed in the prenatal period [ 11 ]. Additionally, some animal studies suggested that the possibility of harmfulness to other systems, including the hepatic system and thyroid [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Association between urinary 3-phenoxybenzoic acid and body mass index in Korean adults: 1st Korean National Environmental Health Survey

Yoo¹,

Lim²,

Kim³

et al. 2016

Ann of Occup and Environ Med

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BackgroundAccording to US-EPA report, the use of pyrethrins and pyrethroids has increased during the past decade, and their area of use included not only in agricultural settings, but in commerce, and individual household. It is known that urinary 3-PBA, major metabolite of pyrethroid, have some associations with health effect in nervous and endocrine system, however, there’s no known evidence that urinary 3-PBA have associations with obesity.MethodWe used data of 3671 participants aged above 19 from the Korean National Environmental Health Survey in 2009–2011. In our analysis, multivariate piece-wise regression and logistic regression analysis were used to investigate the association between urinary 3-PBA (3-Phenoxybenzoic Acid) and BMI.ResultLog-transformed level of urinary 3-PBA had significantly positive association with BMI at the low-level range of exposure (p < 0.0001), and opposite associations were observed at the high level exposure (p = 0.04) after adjusting covariates. In piece-wise regression analysis, the flexion point that changes direction of the associations was at around 4 ug/g creatinine of urinary 3-PBA. As quintiles based on concentration of urinary 3-PBA increased to Q4, the ORs for prevalence of overweight (BMI ≥ 23 kg/m2) were increased, and the OR of Q5 was lower than that of Q4 (OR = 1.810 for Q4; OR = 1.483 for Q5). In the analysis using obesity (BMI ≥ 25 kg/m2) as outcome variable, significant associations were observed between obesity and quintiles of 3-PBA, however, there were no differences between the OR of Q5 and that of Q4 (OR = 1.659 for Q4; OR = 1.666 for Q5).ConclusionOur analysis suggested that low-level of pyrethroid exposure has positive association with BMI, however, there is an inverse relationship above the urinary 3-PBA level at 4 ug/g creatinine.Electronic supplementary materialThe online version of this article (doi:10.1186/s40557-015-0079-7) contains supplementary material, which is available to authorized users.

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Effect of Synthetic Pyrethroid Pesticide Exposure During Pregnancy on the Growth and Development of Infants

Cited by 66 publications

References 14 publications

Urinary biomarkers of exposure to insecticides, herbicides, and one insect repellent among pregnant women in Puerto Rico

Urinary biomarkers of exposure to insecticides, herbicides, and one insect repellent among pregnant women in Puerto Rico

Developmental neurotoxicity of succeeding generations of insecticides

Association between urinary 3-phenoxybenzoic acid and body mass index in Korean adults: 1st Korean National Environmental Health Survey

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