Effect of Synthetic Acyclic Polyisoprenoids on the Cold-Restraint Stress Induced Gastric Ulcer in Rats

Murakami, Manabu; Oketani, Kiyoshi; Fujisaki, Hideaki; Wakabayashi, Tsuneo; Inai, Yuichi; Abe, Shinya; Yamatsu, Isao; Ohgo, Toshiharu

doi:10.1016/s0021-5198(19)52490-8

Cited by 3 publications

(1 citation statement)

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“…Apart from their natural occurrence, poly-trans prenylacetones (C 18 , C 23 , C 28 , C 33 , C 43 , and C 48 ) have been chemically synthesized, and the antiulcer effects of those acyclic acetones on cold-restraint stress induced gastric ulcers in rats were reported [56]. Geranylgeranyl acetone mixed with geranylneryl acetone showed a particularly potent antiulcer effect.…”

Section: Poly-trans Prenylacetonementioning

confidence: 99%

The history and recent advances in research of polyprenol and its derivatives

Sagami

Świeżewska

Shidoji

2018

Bioscience, Biotechnology, and Biochemistry

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The reduction pathway leading to the formation of dolichol was clarified in 2010 with the identification of SRD5A3, which is the polyprenol reductase. The finding inspired us to reanalyze the length of the major chain of polyprenol and dolichol from several plant leaves, including mangrove plants, as well as from animal and fish livers by 2D-TLC. Polyprenol- and dolichol-derived metabolites such as polyprenylacetone and epoxydolichol were found together with rubber-like prenol. This review focuses on analyses of polyprenol and its derivatives, including recently found epoxypolyprenol and polyprenylacetone. Attention has also been paid to the chromatographic behavior of rubber-like prenol on TLC.

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Section: Poly-trans Prenylacetonementioning

confidence: 99%