Effect of sympathomimetic amines on the synaptosomal transport of noradrenaline, dopamine and 5-hydroxytryptamine

Acute Handling Stress Modulates Methylphenidate-induced Catecholamine Overflow in the Medial Prefrontal Cortex

“…This is consistent with the demonstrated affinity of MP for NET (Gatley et al 1996), and the report that the NET has a higher affinity for DA than for NE (Raiteri et al 1977). The influential role of the NET in regulating DA overflow in the mPFC is further supported by a study resulting in significant DA increase after infusion of selective NET blocker desipramine (Gresch et al 1995).…”

Atomoxetine Increases Extracellular Levels of Norepinephrine and Dopamine in Prefrontal Cortex of Rat A Potential Mechanism for Efficacy in Attention Deficit/Hyperactivity Disorder

“…The transporters for NE are relatively abundant compared with DA transporters in the PFC (Gehlert et al 1993;Soucy et al 1997;Coulter et al 1995;Sesack et al 1998) and it has been determined that DA is taken up non-selectively by NE transporters in the PFC (Carboni et al 1990;Di Chiara et al 1992;Tanda et al 1997;Yamamoto and Novotney 1998) as well as co-released (Devoto et al 2001). The NE transporter has similar affinities for NE and DA (Raiteri et al 1977) and presumably extracellularly-released DA may diffuse transsynaptically to NE transporters (Yamamoto and Novotney 1998). Consistent with this hypothesis, locally administered atomoxetine increased both NE EX and DA EX in the PFC, but not to the magnitude seen with systemic administration.…”

There and Back Again: A Tale of Norepinephrine and Drug Addiction

“…The plasma membrane NET, which is responsible for the uptake of extracellular NE, is also capable of transporting DA in vitro (Raiteri et al, 1977). This raises the possibility that the NET may be at least partially responsible for DA uptake in brain regions innervated by both DA and NE neurons.…”