Effect of sympathetic nervous activity on alveolar bone loss induced by occlusal hypofunction in rats

Shimizu, Yasuhiro; Hosomichi, Jun; Kaneko, Sawa; Shibutani, Naoki; Ono, Takashi

doi:10.1016/j.archoralbio.2011.05.004

Cited by 33 publications

(44 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A total of 10 papers investigated the effect of mechanical loading, through diet texture modification and mastication [7], [11], [13], [19], [27], [29], [31], [36], [37], [38] on the bone micro-architecture, while 8 addressed the effect of drug intervention [3], [12], [32], [34], [39], [40], [41], [42]. One paper investigated the mandibular bone architecture in the ovariectomy-induced osteoporotic animal [43].…”

Section: Resultsmentioning

confidence: 99%

Micro-CT analysis of the rodent jaw bone micro-architecture: A systematic review

et al. 2015

View full text Add to dashboard Cite

IntroductionKnowledge about macro- and micro-structural characteristics may improve in vivo estimation of the quality and quantity of regenerated bone tissue. For this reason, micro-CT imaging has been applied to evaluate alveolar bone remodelling, alterations of periodontal ligament thickness and cortical and trabecular bone changes in rodent jaw bones. In this paper, we provide a systematic review on the available micro-CT literature on jaw bone micro-architecture.MethodologyA detailed search through the PubMed database was performed. Articles published up to December 2013 and related to maxilla, mandible and condyle with quantitatively analysed bone micro-architectural parameters were considered eligible for inclusion. Two reviewers assessed the search results according to inclusion criteria designed to identify animal studies quantifying the bone micro-architecture of the jaw rodent bones in physiological or drug-induced disease status, or in response to interventions such as mechanical loading, hormonal treatment and other metabolic alterations. Finally, the reporting quality of the included publications was evaluated using the tailored ARRIVE guidelines outlined by Vignoletti and Abrahamsson (2012).ResultsDatabase search, additional manual searching and assessment of the inclusion and exclusion criteria retrieved 127 potentially relevant articles. Eventually, 14 maxilla, 20 mandible and 12 condyle articles with focus on bone healing were retained, and were analysed together with 3 methodological papers. Each study was described systematically in terms of subject, experimental intervention, follow-up period, selected region of interest used in the micro-CT analysis, parameters quantified, micro-CT scanner device and software. The evidence level evaluated by the ARRIVE guidelines showed high mean scores (between 18 and 25; range: 0–25), indicating that most of the selected studies are well-reported. The major obstacles identified were related to sample size calculation, absence of adverse event descriptions, randomization or blinding procedures.ConclusionsThe evaluated studies are highly heterogeneous in terms of research topic and the different regions of interest. These results illustrate the need for a standardized methodology in micro-CT analysis. While the analysed studies do well according to the ARRIVE guidelines, the micro-CT procedure is often insufficiently described. Therefore we recommend to extend the ARRIVE guidelines for micro-CT studies.

show abstract

Section: Resultsmentioning

confidence: 99%

Micro-CT analysis of the rodent jaw bone micro-architecture: A systematic review

et al. 2015

View full text Add to dashboard Cite

show abstract

“…In addition, histological findings showed trabecular bone loss and enlargement of the bone marrow cavity; however, trabeculae attached to the periodontal ligament remained in the rats fed the normal calcium and soft diet. Shimizu et al 20 indicated that alveolar trabecular bone loss induced by occlusal hypofunction caused a reduction in its volume to the minimum necessary in the absence of forces stimulating the alveolar bone in growing rats. These findings indicated that the sites of remaining trabeculae (not resorbed) with the soft diet were associated with the loading direction of occlusal force in the maxilla as well as the mandible in growing rats.…”

Section: Discussionmentioning

confidence: 99%

Influence of differences in the hardness and calcium content of diets on the growth of craniofacial bone in rats

Goto

Fujita

Hotta

et al. 2015

The Angle Orthodontist

View full text Add to dashboard Cite

Objective: To examine the effects of a soft diet and a low-calcium diet on the craniofacial growth and bone architectures of the maxilla and mandible. Materials and Methods: Male rats (n 5 20, 3 weeks old) were divided into four groups. Ten rats were given a normal-calcium diet, and the other rats were given a low-calcium diet. Each group was then divided into two subgroups, which were fed a hard or a soft diet. After 4 weeks, craniofacial growth and architecture in maxillary and mandibular bone were analyzed using cephalometry, micro-computed tomography, and histopathology. Results: The low-calcium diet had no effect on serum calcium levels. The low-calcium diet had the greatest effect on craniofacial bone growth, while the soft diet affected the growth of several bone sites that are attached to the masseter muscle. A low-calcium diet resulted in the deterioration of the connectivity of the trabeculae in the furcation region of the maxillary and mandibular first molar, while a soft diet resulted in the diffuse disappearance of trabeculae in the central part of the furcation regions. In the midpalatal suture, a low-calcium diet resulted in inhibition of cartilaginous ossification, although the midpalatal suture had a normal cartilaginous structure. A soft diet resulted in narrower cartilage cell layers in the midpalatal suture. Conclusions: We demonstrated that a low-calcium diet and a soft diet resulted in a deterioration of bone structures in both the maxilla and in the mandible; however, the mechanisms underlying these effects differed between diets. (Angle Orthod. 2015;85:969-979.)

show abstract

“…Similarly to the organization of the structure of the PDL in response to occlusal force, ‘bone trabeculae [are] arranged in response to stress lines on the bone’ . When there are no forces stimulating the alveolar bone it undergoes resorption to reduce its volume to the minimum necessary . This phenomenon is best illustrated in the edentulous patient in whom the mandible and maxilla are progressively reduced to a small portion of their original size after loss of teeth .…”

Section: Discussionmentioning

confidence: 99%

Influence of masticatory hypofunction on the alveolar bone and the molar periodontal ligament space in the rat maxilla

Denes

Mavropoulos

Bresin

et al. 2013

European J Oral Sciences

View full text Add to dashboard Cite

Previous studies have established that complete absence of masticatory function results in a narrower alveolar process and periodontal ligament (PDL). The aim of our study was to investigate, for the first time, both the alveolar process and the PDL in masticatory hypofunction. Twenty-six rats, 3 wk of age, were randomly assigned to either a hard- or a soft-diet group (n = 13 each group). The rats were killed after 6 wk and their skulls were scanned using micro-computed tomography (micro-CT). We measured the cross-sectional width of the space occupied by the PDL, as well as the cross-sectional alveolar socket surface (AS) and the cross-sectional root surface (RS). We also measured the width of the alveolar process. The alveolar process was narrower, the PDL width was thinner, and the AS was smaller in rats fed a soft diet compared with rats fed a hard diet. The PDL width was correlated to the alveolar process width and the AS. The narrower alveolar process found in rats fed a soft diet is the result of alterations to both the alveolar bone and the PDL. The correlation between them provides evidence that a reduction of occlusal loading induces a simultaneous response in both tissues.

show abstract

Effect of sympathetic nervous activity on alveolar bone loss induced by occlusal hypofunction in rats

Cited by 33 publications

References 30 publications

Micro-CT analysis of the rodent jaw bone micro-architecture: A systematic review

Micro-CT analysis of the rodent jaw bone micro-architecture: A systematic review

Influence of differences in the hardness and calcium content of diets on the growth of craniofacial bone in rats

Influence of masticatory hypofunction on the alveolar bone and the molar periodontal ligament space in the rat maxilla

Contact Info

Product

Resources

About