Effect of sympathectomy on microvascular anastomosis in the rat

Hweidi, Sobhi A.; Lee, Sun; Wolf, Paul L.

doi:10.1002/micr.1920060207

Cited by 4 publications

(2 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therapeutically, lumbar sympathectomy has been used to improve the patency after small blood vessel anastomosis, [17][18][19] while Hwiedi et al 20 demonstrated no difference in the microvascular patency rate after lumbar sympathectomy after femoral anastomosis in rats.…”

Section: Discussionmentioning

confidence: 99%

Catecholamine sensitivity in the rat femoral artery after microvascular anastomosis

et al. 2000

View full text Add to dashboard Cite

Tissue can demonstrate vasospastic instability after microvascular anastomosis. This study investigates the in vitro effect of increasing concentrations of phenylephrine on the rat femoral artery after microvascular anastomosis. Bilateral groin flaps based on the inferior epigastric artery were raised on 55 Wistar male rats. On the test side, a microvascular anastomosis was performed, but not on the control side. On days 2–12 postoperatively, the rats were sacrificed and the femoral arteries harvested and suspended in increasing concentrations of phenylephrine. The vascular tone on the test and control sides were recorded and compared. Increased sensitivity was found on the test side as compared with the control side (P = 0.000). This supersensitivity to phenylephrine was blocked by the addition of phentolamine and it is believed to be the result of sympathetic denervation, which occurs when the sympathetic fibers are cut during the harvesting of the flap. The resulting vascular instability is believed to contribute to flap failure. © 2000 Wiley‐Liss, Inc. MICROSURGERY 20:217–220 2000

show abstract

Section: Discussionmentioning

confidence: 99%

Catecholamine sensitivity in the rat femoral artery after microvascular anastomosis

et al. 2000

View full text Add to dashboard Cite

show abstract

“…In the nerve‐transection group, the saphenous nerve was transected at the root. In the lumbar sympathectomy group, bilateral lumbar sympathetic trunks were removed with the procedures described by Hweidi 22 . Briefly, a longitudinal incision from the xiphoid process to the pubic symphysis was first made along the abdominal skin and the linea alba to open the abdominal cavity.…”

Section: Methodsmentioning

confidence: 99%

Segmental branches emanating from saphenous nerve morphing into sympathetic trunks for innervation of saphenous artery and its clinical implication for arterial sympathectomy

Xie

Fang

Lin

et al. 2021

International Wound Journal

View full text Add to dashboard Cite

Sympathectomy of arteries has been adopted for the treatment of peripheral arterial disease and Raynaud's disease. However, the exact route for sympathetic axons to reach peripheral arteries awaits further investigation that could pave the way for development of new surgical strategies. In this study, saphenous neurovascular bundles from 10 neonatal Sprague‐Dawley rats first were harvested for whole‐mount immunostaining to show sympathetic innervation pattern of the artery. Secondly, 40 Sprague‐Dawley male rats weighing 350 to 400 g were assigned to five groups, receiving either sham, perivascular sympathectomy, nerve‐artery separation, nerve transection in the saphenous neurovascular bundle, or lumbar sympathectomy surgery that removes the lumbar sympathetic trunks. Immediately after surgery, the arterial perfusion and diameter were measured using laser speckling contrast imaging, and 1 week later the saphenous neurovascular bundles were harvested for immunostaining using antibodies against TH, neuron‐specific β‐tubulin (Tuj 1), and α‐SMA to show the presence or absence of the TH‐immuopositive staining in the adventitia. The differences among the five groups were determined using one‐way analysis of variance (ANOVA). We found that an average of 2.8 ± 0.8 branches with a diameter of 4.8 ± 1.2 μm derived from the saphenous nerve that morphed into a primary and a secondary sympathetic trunk for innervation of the saphenous artery. Nerve‐artery separation, nerve transection, and lumbar sympathectomy could eradicate TH‐immunopositive staining of the artery, resulting, respectively, in a 12%, 36%, and 59% increase in diameter (P < .05), and a 52%, 63%, and 201% increase in perfusion compared with sham surgery (P < .01). In contrast, perivascular sympathectomy did not have a significant impact on the TH‐immunopositive staining, the diameter, and perfusion of the distal part of the artery (P > .05). We conclude that the sympathetic innervation of an artery derives from segmental branches given off from its accompanying nerve. Nerve‐artery disconnection is a theoretic option in sympathectomy of an artery.

show abstract

Lumbar sympathectomy reduces vascular permeability, possibly through decreased adenosine receptor A2a expression in the hind plantar skin of rats

Zheng

Liu

Zhu

et al. 2018

View full text Add to dashboard Cite

show abstract

Effect of sympathectomy on microvascular anastomosis in the rat

Cited by 4 publications

References 3 publications

Catecholamine sensitivity in the rat femoral artery after microvascular anastomosis

Catecholamine sensitivity in the rat femoral artery after microvascular anastomosis

Segmental branches emanating from saphenous nerve morphing into sympathetic trunks for innervation of saphenous artery and its clinical implication for arterial sympathectomy

Lumbar sympathectomy reduces vascular permeability, possibly through decreased adenosine receptor A2a expression in the hind plantar skin of rats

Contact Info

Product

Resources

About