Effect of swinging on EEG of rats of juvenile age in the wakefulness state

Lychakov, D. V.; Аристакесян, Е.А.; Oganesyan, G. A.

doi:10.1134/s002209300705009x

Cited by 3 publications

(3 citation statements)

References 11 publications

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“…Registration and analysis of the brain's electrical activity (electroencephalography, EEG; electrocorticography, ECoG) are also used in experimental studies of rodents [4,5]. In several pilot studies, we examined and described typical alterations of brain electrical activity observed in rats subjected to penetrating TBI [6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Effects of Alpha-2 Adrenergic Agonist Mafedine on Brain Electrical Activity in Rats after Traumatic Brain Injury

et al. 2021

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The search for and development of new neuroprotective (or cerebroprotective) drugs, as well as suitable methods for their preclinical efficacy evaluation, are priorities for current biomedical research. Alpha-2 adrenergic agonists, such as mafedine and dexmedetomidine, are a highly appealing group of drugs capable of reducing neurological deficits which result from brain trauma and vascular events in both experimental animals and human patients. Thus, our aim was to assess the effects of mafedine and dexmedetomidine on the brain’s electrical activity in a controlled cortical-impact model of traumatic brain injury (TBI) in rats. The functional status of the animals was assessed by electrocorticography (ECoG), using ECoG electrodes which were chronically implanted in different cortical regions. The administration of intraperitoneal mafedine sodium at 2.5 mg∙kg−1 at 1 h after TBI induction, and daily for the following 6 days, restored interhemispheric connectivity in remote brain regions and intrahemispheric connections within the unaffected hemisphere at post-TBI day 7. Animals that had received mafedine sodium also demonstrated an improvement in cortical responses to photic and somatosensory stimulation. Dexmedetomidine at 25 μg∙kg−1 did not affect the brain’s electrical activity in brain-injured rats. Our results confirm the previously described neuroprotective effects of mafedine sodium and suggest that ECoG registration and analysis are a viable method evaluating drug efficacy in experimental animal models of TBI.

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Section: Introductionmentioning

confidence: 99%

Effects of Alpha-2 Adrenergic Agonist Mafedine on Brain Electrical Activity in Rats after Traumatic Brain Injury

et al. 2021

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“…The resonance hypothesis is supported by experiments which had shown the increase EEG power spectral level in the low-delta band, firstly, along with the level of motion sickness symptoms in human subjects exposed to cross-coupled angular stimulation [7], secondly, during drum rotation in those subjects who developed severe symptoms of motion sickness [14], and, thirdly, in hypothalamus and hippocampus in awake juvenile rats after swinging [20]. On the other hand, there are good reasons to believe that the evolutionary transition between amphibians and reptiles is associated with the emergence of emotion [4,5], and, thus, emotions are absent in amphibians, they have no NC and do not suffer from motion sickness.…”

Section: Why Lower Vertebrates Could Be Immune To Motion Sicknessmentioning

confidence: 99%

Behavior of toads, Bufo bufo, in a dynamic environment

Lychakov

2010

VES

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Susceptibility to motion sickness was tested by exposing free moving toads to rotation of a stimulator modeled after an amusement park Ferris Wheel. The stimulator provided a gentle stimulation of frequency 0.25 Hz and centrifugal acceleration 0.143 g during 120 min or more without external visual cues. No emetic or prodromal behavioral response was elicited during or after rotation. During rotation the amount of motor activity in most toads increased evidently. The most active toads attempted to climb out of the test chamber. It was inferred that experimental rotation was rather a stressful stimulus which initiated an escape response. In addition, during rotation the number of eye retractions and urination incidences increased, but appetite after rotation was inhibited. During rotation the motionless toads performed small regular head movements with period equal to rotation period of stimulator. These oscillations were probably vestibular (otolith) reaction to oscillating acceleration. The proposed resonance hypothesis gives a general idea of why lower vertebrates are immune to motion sickness.

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“…Yet, the common approach to cellular and network-level investigation of development in animal models has until now been limited to comparing data from pre-adolescents (Spear, 2000;Kilb, 2011) with adults (Pen et al, 2006;Hogsden and Dringenberg, 2009;Gvilia et al, 2011;Sturman and Moghaddam, 2011a). Strong and rigorous research was primarily aimed at the role and mechanisms of oscillations, both local and transmitted between regions, in neonates (Leinekugel et al, 1997(Leinekugel et al, , 2002Garaschuk et al, 1998;Khazipov et al, 2004;Buhl and Buzsaki, 2005;Ben-Ari et al, 2007;Minlebaev et al, 2007;Mohns et al, 2007;Brockmann et al, 2011;Del Rio-Bermudez et al, 2017;Griguoli and Cherubini, 2017;Ahlbeck et al, 2018) while periadolescent stages remain much less explored (Sato et al, 1979;Konopacki et al, 1988;Slawecki, 2002;Slawecki and Ehlers, 2003;Lychakov et al, 2007;Burton et al, 2008;Pian et al, 2008;Ehlers et al, 2013Ehlers et al, , 2018Caban et al, 2018;Buzzell et al, 2019;Medlej et al, 2019;Muessig et al, 2019;Zhang et al, 2019).…”

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confidence: 99%

Development of network oscillations through adolescence in male and female rats

Sibilska

Mofleh

Kocsis

2023

Front. Cell. Neurosci.

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The primary aim of this research was to study the developmental trajectory of oscillatory synchronization in neural networks of normal healthy rats during adolescence, corresponding to the vulnerable age of schizophrenia prodrome in human. To monitor the development of oscillatory networks through adolescence we used a “pseudo-longitudinal” design. Recordings were performed in terminal experiments under urethane anesthesia, every day from PN32 to PN52 using rats-siblings from the same mother, to reduce individual innate differences between subjects. We found that hippocampal theta power decreased and delta power in prefrontal cortex increased through adolescence, indicating that the oscillations in the two different frequency bands follow distinct developmental trajectories to reach the characteristic oscillatory activity found in adults. Perhaps even more importantly, theta rhythm showed age-dependent stabilization toward late adolescence. Furthermore, sex differences was found in both networks, more prominent in the prefrontal cortex compared with hippocampus. Delta increase was stronger in females and theta stabilization was completed earlier in females, in postnatal days PN41-47, while in males it was only completed in late adolescence. Our finding of a protracted maturation of theta-generating networks in late adolescence is overall consistent with the findings of longitudinal studies in human adolescents, in which oscillatory networks demonstrated a similar pattern of maturation.

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Effect of swinging on EEG of rats of juvenile age in the wakefulness state

Cited by 3 publications

References 11 publications

Effects of Alpha-2 Adrenergic Agonist Mafedine on Brain Electrical Activity in Rats after Traumatic Brain Injury

Effects of Alpha-2 Adrenergic Agonist Mafedine on Brain Electrical Activity in Rats after Traumatic Brain Injury

Behavior of toads, Bufo bufo, in a dynamic environment

Development of network oscillations through adolescence in male and female rats

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