Effect of sustained-release theophylline administration on pituitary-thyroid axis

Hiratani, Michio; Muto, K; Oshida, Y; Ito, Shigeru; Kasei, Masaharu; Ueda, Shunsaku; Satô, Tamotsu

doi:10.1016/0091-6749(82)90012-4

Cited by 8 publications

(10 citation statements)

References 20 publications

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“…However, in general these caffeine/coffee specific effects are subject of a controversial debate and were not always confirmed. Regarding THs, an over 30 year old study investigated the effect of theophylline administration every 12 hour for 60 hour on the pituritary-thyroid axis in four healthy adults [ 36 ]. Plasma total T4 levels showed a simultaneous increase with theophylline levels over the whole experiment time and were accompanied by an increase in plasma as well as urinary cyclic adenosine 3',5'-monophosphate (cAMP) levels.…”

Section: Discussionmentioning

confidence: 99%

Urinary metabolomics reveals glycemic and coffee associated signatures of thyroid function in two population-based cohorts

et al. 2017

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BackgroundTriiodothyronine (T3) and thyroxine (T4) as the main secretion products of the thyroid affect nearly every human tissue and are involved in a broad range of processes ranging from energy expenditure and lipid metabolism to glucose homeostasis. Metabolomics studies outside the focus of clinical manifest thyroid diseases are rare. The aim of the present investigation was to analyze the cross-sectional and longitudinal associations of urinary metabolites with serum free T4 (FT4) and thyroid-stimulating hormone (TSH).MethodsUrine Metabolites of participants of the population-based studies Inter99 (n = 5620) and Health2006/Health2008 (n = 3788) were analyzed by 1H-NMR spectroscopy. Linear or mixed linear models were used to detect associations between urine metabolites and thyroid function.ResultsCross-sectional analyses revealed positive relations of alanine, trigonelline and lactic acid with FT4 and negative relations of dimethylamine, glucose, glycine and lactic acid with log(TSH). In longitudinal analyses, lower levels of alanine, dimethylamine, glycine, lactic acid and N,N-dimethylglycine were linked to a higher decline in FT4 levels over time, whereas higher trigonelline levels were related to a higher FT4 decline. Moreover, the risk of hypothyroidism was higher in subjects with high baseline trigonelline or low lactic acid, alanine or glycine values.ConclusionThe detected associations mainly emphasize the important role of thyroid hormones in glucose homeostasis. In addition, the predictive character of these metabolites might argue for a potential feedback of the metabolic state on thyroid function. Besides known metabolic consequences of TH, the link to the urine excretion of trigonelline, a marker of coffee consumption, represents a novel finding of this study and given the ubiquitous consumption of coffee requires further research.

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Section: Discussionmentioning

confidence: 99%

Urinary metabolomics reveals glycemic and coffee associated signatures of thyroid function in two population-based cohorts

et al. 2017

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“…We did not observe any effect of theophylline on TSH and fT 4 , because their concentrations were the same in patients and control groups (table 2). However, other studies have reported an association between the levels of theophylline and TSH [10][11][12]: as concentrations of theophylline increased, concentrations of TSH and fT 4 also increased.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary Function Tests and Thyroid Hormone Concentrations in Patients with Chronic Obstructive Pulmonary Disease

Okutan

Kartaloğlu²,

M³

et al. 2004

Med Princ Pract

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Objective: To evaluate the relationship between pulmonary function tests, arterial blood gases, and thyroid gland functions in patients with chronic obstructive pulmonary disease (COPD). Subjects and Methods: Thirty-two patients (mean age 64.1 ± 7.3 years, range 53–84 years) with stable COPD (mean duration of disease 11.1 ± 9.1 years, range 1–30 years) and 15 healthy control cases participated in the study. Pulmonary function, arterial blood gas, and thyroid hormone concentration were measured, and thyroid ultrasonography and scintigraphy were also performed. Results: The values of the pulmonary function tests (vital capacity, forced vital capacity, forced expiratory volume in 1 s and peak expiratory flow) and PaO₂ were lower in the study than control group (p < 0.001), but the values of PaCO₂ and concentration of free 3,5,3′-triiodothyronine (fT₃) were higher in the study than control group (p < 0.01) although thyroid hormone concentrations were within normal limits in all cases. However, there was no difference between the values of thyroid-stimulating hormone and free thyroxine in both the study and control groups and therefore association could not be established between them on the one hand and pulmonary function test and arterial blood gases on the other hand. Only the values of PaCO₂ and fT₃ were positively associated; all other values were negatively associated with fT₃. Conclusion: Changes in pulmonary function tests and arterial blood gases seem to be associated with fT₃ concentrations in patients with COPD. Increased respiratory workload could affect thyroid functions.

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“…58 Many frequently used medications also affect concentrations of thyroid hormones in a complex manner. For example, aminophylline, which is used as a respiratory stimulant in preterm infants with recurrent apnoea, increases TSH, 59 TT4 58,59 and TT3 concentrations 58 whereas theophylline, a metabolite of aminophylline, increases plasma TT4 concentrations in adults and children, with inconsistent effects on TT3 and rT3; 60 although prolonged administration of theophylline to infants has no effect on thyroid hormone concentrations. 61 Glucocorticoids, which are used to mitigate chronic lung disease in preterm infants, have various effects on the pituitary–thyroid axis.…”

Section: Aetiology Of Transient Hypothyroxinaemiamentioning

confidence: 99%

“…58,59 and TT3 concentrations 58 whereas theophylline, a metabolite of aminophylline, increases plasma TT4 concentrations in adults and children, with inconsistent effects on TT3 and rT3; 60 although prolonged administration of theophylline to infants has no effect on thyroid hormone concentrations. 61 Glucocorticoids, which are used to mitigate chronic lung disease in preterm infants, have various effects on the pituitary-thyroid axis.…”

Section: Tt4mentioning

confidence: 99%

The measurement, definition, aetiology and clinical consequences of neonatal transient hypothyroxinaemia

Williams

Hume

2010

Ann Clin Biochem

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This review focuses on neonatal transient hypothyroxinaemia, a condition characterized by temporary postnatal reductions in concentrations of Total T4 or Free T4, with normal or low concentrations of thyroid stimulating hormone (TSH). There is neither an agreed quantitative definition, nor an agreed mode of measurement for the condition. Transient hypothyroxinaemia is not routinely monitored yet it is thought to affect about 50% of preterm infants; it was thought to be without long-term sequelae but observational studies indicate that neurodevelopment may be compromised. The aetiology of transient hypothyroxinaemia is complex. There are significant contributions from the withdrawal of maternal -placental thyroxine transfer, hypothalamic-pituitary -thyroid immaturity, developmental constraints on the synthesis and peripheral metabolism of iodothyronines and iodine deficiency. It is not possible to distinguish clinically, or from laboratory measurements, whether transient hypothyroxinaemia is an independent condition or simply a consequence of non-thyroidal illness and/or drug usage. An answer to this question is important because studies of thyroid hormone replacement have been instigated, with mixed results. Until the aetiology of transient hypothyroxinaemia is better understood it would seem prudent not to routinely supplement preterm infants with thyroid hormones. Iodine deficiency, non-thyroidal illness and drug usage are the most modifiable risk factors for transient hypothyroxinaemia and are the clear choices for attempts at reducing its incidence. We suggest that transient hypothyroxinaemia in preterm infants is defined as a normal or low TSH concentration in conjunction with a concentration of Total T4, that is 10th percentile of cord Total T4 of the equivalent gestational age had the infant remained in utero.Ann Clin Biochem 2011; 48: 7-22.

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Effect of sustained-release theophylline administration on pituitary-thyroid axis

Cited by 8 publications

References 20 publications

Urinary metabolomics reveals glycemic and coffee associated signatures of thyroid function in two population-based cohorts

Urinary metabolomics reveals glycemic and coffee associated signatures of thyroid function in two population-based cohorts

Pulmonary Function Tests and Thyroid Hormone Concentrations in Patients with Chronic Obstructive Pulmonary Disease

The measurement, definition, aetiology and clinical consequences of neonatal transient hypothyroxinaemia

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