Effect of Surgically Removing Subcutaneous Fat by Abdominoplasty on Leptin Concentrations and Insulin Sensitivity

Martı́nez-Abundis, Esperanza; Molina-Villa, Carlos Alejandro; González-Ortı́z, Manuel; Robles-Cervantes, José Antonio; Saucedo-Ortiz, José Antonio

doi:10.1097/01.sap.0000240033.00047.cc

Cited by 24 publications

(20 citation statements)

References 31 publications

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“…A reduction of serum leptin concentrations was also observed in obese women after surgical removal of subcutaneous adipose tissue [12,13] . Assuming that a high serum leptin concentration is responsible for the downregulation of lipogenic enzyme gene expression in WAT of old rats, the decrease in plasma leptin concentration, due to surgical removal of abdominal (perirenal and epididymal) fat pads, should lead to an increase of lipogenic enzyme activities.…”

Section: Introductionmentioning

confidence: 77%

Surgical Removal of Perirenal and Epididymal Adipose Tissue Decreases Serum Leptin Concentration and Increases Lipogenic Enzyme Activities in Remnant Adipose Tissue of Old Rats

Nogalska

Stelmańska²,

Śledziński³

et al. 2008

Gerontology

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Background: The rate of lipogenesis and gene expression of lipogenic enzymes in white adipose tissue (WAT) of rats decreases with age. Previously, we showed the inverse relationship between serum leptin concentration and lipogenic enzymes activities in WAT of ageing rats. Based on those results, we postulated that leptin could play some role in the downregulation of lipogenic enzyme genes expression in WAT of old rats. Objective: To further test this hypothesis, in the present paper we examined the effect of surgical removal of perirenal and epididymal WAT on serum leptin concentration and lipogenic enzymes activities in remnant adipose tissue of old rats. Methods: One-year-old rats, which display a high serum leptin concentration and low lipogenic enzyme activities in WAT, were subjected to surgical removal of the perirenal and epididymal WAT. Two months after the surgery, the serum leptin concentration and lipogenic enzyme activities in remnant WAT were compared to the serum leptin concentration and lipogenic enzyme activities measured in adipose tissue collected during the surgery. Results: WAT removal resulted in an approximately 6-fold decrease of serum leptin concentration and about a 2-fold increase of lipogenic enzyme activities in remnant adipose tissue. Conclusions: These results indicate that interventions designed to reduce abdominal adipose tissue mass can change the lipogenic activity of remnant adipose tissue. Additionally, leptin could be one of the factors contributing to the downregulation of the genes expression of lipogenic enzymes during ageing in rats.

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Section: Introductionmentioning

confidence: 77%

Surgical Removal of Perirenal and Epididymal Adipose Tissue Decreases Serum Leptin Concentration and Increases Lipogenic Enzyme Activities in Remnant Adipose Tissue of Old Rats

Nogalska

Stelmańska²,

Śledziński³

et al. 2008

Gerontology

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“…In contrast, D'Andrea et al [30] performed a similar study in obese females with normal glucose tolerance and found that an averaged weight lost of 3.6 kg by liposuction was associated with significant improvements in insulin-sensitivity. These conflicting results were reproduced in other studies; some of the studies demonstrated an improvement [28,31,32], whereas others did not [33,34]. However, data from these studies were confounded by multiple factors.…”

Section: Figure 2 Factors Determining Adipose Tissue Expansionmentioning

confidence: 91%

Adipose tissue expandability: the metabolic problems of obesity may arise from the inability to become more obese

Tan

Vidal-Puig

2008

Biochemical Society Transactions

152

103

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The prevalence of obesity is increasing and with it the prevalence of associated metabolic complications. Precisely how obesity results in metabolic disturbances remains unclear. In the face of persistent positive caloric balance, it has been postulated that the capacity of adipose tissue to safely store fat may be vital. This paper explores some of the evidence suggesting that the risk of developing metabolic disturbances is not related to how much fat an individual has, but how well their fat can expand to accommodate the caloric excess. If this is true, the metabolic consequences of obesity may arise from the inability to become more obese.

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“…However, health consequences of liposuction are still poorly understood. Moreover, the results of previous studies dealing with the problem in question are inconclusive [2,3,4,5,6]. Nevertheless, some authors showed that liposuction is safe and beneficial procedure resulting in an amelioration of insulin resistance and decrease in the markers of vascular inflammation [2,3,4,5].…”

Section: Introductionmentioning

confidence: 90%

Up-Regulation Mttp and Apob Gene Expression in Rat Liver is Related to Post-Lipectomy Hypertriglyceridemia

Dettlaff-Pokora

Śledziński

Świerczyński

2015

Cell Physiol Biochem

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Background/Aims: The aim of this study was to explain the molecular basis for elevated concentrations of circulating triglycerides (TAGs) after partial surgical removal of adipose tissue (lipectomy) in rats. Methods: The levels of mRNA and protein: a) involved in synthesis of fatty acids and TAGs; b) participating in TAG-rich lipoproteins assembly and secretion; and c) transcription factors essential for maintaining TAG homeostasis were determined by RT-PCR and Western Blot in the livers of control and lipectomized rats. Results: Partial lipectomy was associated with increase: a) in serum and liver concentration of TAGs, and b) in the liver levels of mRNA of microsomal TAG transfer protein (MTP) and apolipoprotein B-100 (ApoB-100). These changes were tightly associated with up-regulation of Hnf1a and Hnf4a gene expression in the liver. Lipectomy was also reflected by a significant increase in the expression of genes encoding: a) fatty acid synthase (FASN), b) glycerol 3-phosphate acyltransferase 1 (GPAT1), diacylglycerol acyltransferases 1 and 2 (DGAT1 and DGAT2), c) spot 14 protein (S14) and SREBP-1 in the liver. Conclusion: Coordinated up-regulation of Mttp, Apob, Hnf1a, Hnf4a, Fasn, Gpam and Dgat (1 and 2) gene expressions may contribute to the increase in circulating and liver concentrations of TAGs after lipectomy in an experimental rat model.

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Effect of Surgically Removing Subcutaneous Fat by Abdominoplasty on Leptin Concentrations and Insulin Sensitivity

Cited by 24 publications

References 31 publications

Surgical Removal of Perirenal and Epididymal Adipose Tissue Decreases Serum Leptin Concentration and Increases Lipogenic Enzyme Activities in Remnant Adipose Tissue of Old Rats

Surgical Removal of Perirenal and Epididymal Adipose Tissue Decreases Serum Leptin Concentration and Increases Lipogenic Enzyme Activities in Remnant Adipose Tissue of Old Rats

Adipose tissue expandability: the metabolic problems of obesity may arise from the inability to become more obese

Up-Regulation Mttp and Apob Gene Expression in Rat Liver is Related to Post-Lipectomy Hypertriglyceridemia

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