Effect of surgical technique on in vitro posterior capsule opacification

Davidson, Michael G.; Morgan, D.; McGahan, M.C.

doi:10.1016/s0886-3350(99)00451-4

Cited by 36 publications

(34 citation statements)

References 26 publications

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“…However, the prevalence of PCO in the present study was modest, despite the use of a single-piece PMMA IOL. Less PCO and fewer lens epithelial cells were reported with phacoemulsification compared with extracapsular cataract extraction in an in vitro study in canine eyes 32. Our own experience suggests that cataract surgery by the SLIMCE technique, a modified version of small-incision manual cataract extraction, may be associated with lower rates of PCO.…”

Section: Discussionmentioning

confidence: 61%

Impact of posterior subcapsular opacification on vision and visual function among subjects undergoing cataract surgery in rural China: Study of Cataract Outcomes and Up-Take of Services (SCOUTS) in the Caring is Hip Project, Report 5

Congdon

Choi

et al. 2008

British Journal of Ophthalmology

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Section: Discussionmentioning

confidence: 61%

Impact of posterior subcapsular opacification on vision and visual function among subjects undergoing cataract surgery in rural China: Study of Cataract Outcomes and Up-Take of Services (SCOUTS) in the Caring is Hip Project, Report 5

Congdon

Choi

et al. 2008

British Journal of Ophthalmology

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“…In addition, the canine lens capsule explant model develops identical characteristics of PCO to those of human origin 22 . The influence of the surgical technique and type of intraocular lens implant on the development of PCO in the dog has been evaluated 23,24 . Cell proliferation across the canine posterior lens capsule after phacoemulsification occurred in vitro and the authors proposed that complete removal of residual LECs is necessary to prevent PCO 23 .…”

Section: Introductionmentioning

confidence: 99%

“…The influence of the surgical technique and type of intraocular lens implant on the development of PCO in the dog has been evaluated 23,24 . Cell proliferation across the canine posterior lens capsule after phacoemulsification occurred in vitro and the authors proposed that complete removal of residual LECs is necessary to prevent PCO 23 . Therefore, meticulous capsule vacuuming to remove the residual LECs can have an immediate benefit on posterior capsule clarity, but the long‐term benefit may be limited 23 …”

Section: Introductionmentioning

confidence: 99%

Posterior capsular opacification in diabetic and nondiabetic canine patients following cataract surgery

Bras¹,

Colitz²,

Saville

et al. 2006

Veterinary Ophthalmology

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Posterior capsular opacification (PCO) is the most common postoperative complication of contemporary cataract surgery. Limited information is available regarding PCO formation and factors that influence PCO development in the dog. Two hundred sixty-five eyes (144 from diabetic dogs and 121 from dogs with breed-related cataracts) were prospectively evaluated for PCO formation for up to 12 months postoperatively. The mean age of all dogs in the study was 7.77 years and diabetic dogs were significantly older than dogs with breed-related cataracts. There were 73 males (61 neutered, 12 intact) and 74 females (70 neutered, 4 intact) in the study. Statistical analysis was performed based on age, breed/size, gender, stage of cataract at the time of surgery, PCO score at each time point, breed-related vs. diabetic cataract, right eyes compared to left eyes, and presence/absence of uveitis. Age and gender did not significantly influence PCO formation. Small and medium-sized breeds developed significantly more PCO in comparison to the large/giant breeds at 2 weeks and 2-4 months postoperatively, but the differences were not significant at later time points. There was an overall significant increase in PCO formation in eyes with early immature cataracts when compared to other stages of cataract up to 4 months postoperatively but not at later time points. There were no statistical differences in PCO score at 6 months or at 1 year postoperatively in eyes with breed-related and diabetic cataracts. Right eyes did not differ from left eyes in PCO score. PCO score significantly increased over time in breed-related and diabetic groups and in the overall population. No difference was found in the degree of PCO formation in eyes with inflammation prior to or after surgery compared with those without inflammation. In summary, age, gender, presence of inflammation, and cause of cataract (breed-related vs. diabetes mellitus) do not influence the development of PCO in canine cataract dogs. Small and medium-sized breeds develop significant PCO earlier than larger breeds. It is important to note that all eyes from all dogs in this study developed PCO in a time dependent manner.

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“…At the surgical level attempts were made to polish the lens capsule during surgery and thus effectively eliminate the lens cell epithelial population. However, it now seems that total removal of the cells by this method is virtually impossible and even a small residual cell population can repopulate the posterior capsule (Davidson, Morgan and McGahan, 2000a). Therefore, the major area of development on the surgical front is in the design of intraocular lenses.…”

Section: Prevention Of Pcomentioning

confidence: 99%