Effect of surgical stress on the erythrocyte insulin receptor

Kaukinen, S.; Marttinen, A.; Vuorinen, Pauli; Koivula, Timo

doi:10.1016/s0261-5614(84)80043-6

Cited by 4 publications

(5 citation statements)

References 19 publications

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“…Also, in the present study the serum cortisol concentrations in the hyperglycaemic patients were higher than in the control patients. In the hyperclycaemic-patients PFAs were lower than in the reference patients, as we also found earlier (Kaukinen et al, 1984). Hyperglycaemia inhibits lipolysis, which is otherwise a normal response to trauma.…”

Section: Serum Free Fatty Acids and Cortisolsupporting

confidence: 86%

“…We have previously shown that surgical stress with glucose load reduces the number of insulin receptors and also the receptor affinity to insulin at physiological concentrations (Kaukinen et al, 1984). These receptor changes suggest the development of peripheral insulin resistance at receptor level, which with the increased glucose production elevates blood glucose concentration.…”

Section: Serum Free Fatty Acids and Cortisolmentioning

confidence: 97%

“…Some patients develop postoperative hyperglycaemia. 1f the patient has been given glucose containing infusion fluids, the hyperglycaemic response is accentuated (Kaukinen et al, 1984;Giddings et al, 1977). Serum insulin concentration rises, but is not able to reduce blood glucose (Kaukinen et al, 1984;Giddings et al, 1977).…”

Section: Introductionmentioning

confidence: 99%

“…1f the patient has been given glucose containing infusion fluids, the hyperglycaemic response is accentuated (Kaukinen et al, 1984;Giddings et al, 1977). Serum insulin concentration rises, but is not able to reduce blood glucose (Kaukinen et al, 1984;Giddings et al, 1977). The hyperglycaemic response can be explained partly by increased glucose production due to increased secretion of adrenaline, glucagon and cortisol, and partly by the fact that peripheral tissues may be resistant to the action of insulin and glucose transport into the cells may be inhibited (Morgan et al, 1961;Wright and Henderson, 1975).…”

Section: Introductionmentioning

confidence: 99%

“…glucose load the binding decreased, indicating the development of insulin resistance (Kaukinen et al, 1984). Cellular glucose utilisation can also be reduced (Wright and Henderson, 1975).…”

Section: Introductionmentioning

confidence: 99%

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Postoperative Hyperglycaemia — are the Patients Diabetic?

Kaukinen

Salmi²,

Marttinen³

et al. 2009

Exp Clin Endocrinol Diabetes

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The aim of this study was to investigate the occurrence and causes of postoperative hyperglycaemia. Blood sugar was measured after operation in 262 patients who had undergone minor emergency operations, when the patients were receiving 5% glucose infusion at the rate of 170 ml/h. In 32 patients (12%) blood glucose was over 8.0 mmol/l. Serum insulin concentration in these patients was significantly higher than in reference patients, who had blood glucose below 5.5 mmol/l. The number of insulin receptors in red cells and the affinity of insulin to receptors were similar in both groups. Serum cortisol was higher, but free fatty acid concentration lower, in the hyperglycaemic group than in the reference group. The tests done postoperatively were repeated two weeks later without surgical stress. The values recorded, indicating the patients' normal metabolism, did not differ between the two groups, except that serum cortisol was somewhat higher in the reference patients. The oral glucose tolerance test was normal in all patients except one. The results suggest that patients prone to postoperative hyperglycaemia are not diabetic, but that their production of glucose is increased during surgical stress.

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Section: Serum Free Fatty Acids and Cortisolsupporting

confidence: 86%

Section: Serum Free Fatty Acids and Cortisolmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…glucose load the binding decreased, indicating the development of insulin resistance (Kaukinen et al, 1984). Cellular glucose utilisation can also be reduced (Wright and Henderson, 1975).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations