Effect of Surgical Implantation of Recombinant Human Bone Morphogenetic Protein‐2 in a Bioabsorbable Collagen Sponge or Calcium Phosphate Putty Carrier in Intrabony Periodontal Defects in the Baboon

Blumenthal, Neil M.; Koh-Kunst, Grace; Alves, Mario; Miranda, Dario Augusto Oliveira; Sorensen, Rachel G.; Wozney, John M.; Wikesjö, Ulf M.E.

doi:10.1902/jop.2002.73.12.1494

Cited by 48 publications

(38 citation statements)

References 53 publications

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“…This process is driven by cellular and molecular mechanisms controlled by the TGF-β superfamily of genes, which encodes a large number of extracellular signalling growth factors [16]. Bone morphogenetic proteins (BMPs) are a wellstudied group of these growth factors involved in the processes of bone healing; and the human genome encodes at least 20 of these multifunctional polypeptides [17]. Among several of its functions, BMPs induce the formation of both bone and cartilage by stimulating the cellular events of mesenchymal progenitor cells.…”

Section: Growth Factors For Wound Repairmentioning

confidence: 99%

Growth factor delivery for oral and periodontal tissue engineering

Kaigler

Cirelli

Giannobile

2006

Expert Opinion on Drug Delivery

164

153

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The treatment of oral and periodontal diseases and associated anomalies accounts for a significant proportion of the healthcare burden, with the manifestations of these conditions being functionally and psychologically debilitating. Growth factors are critical to the development, maturation, maintenance and repair of craniofacial tissues, as they establish an extracellular environment that is conducive to cell and tissue growth. Tissue-engineering principles aim to exploit these properties in the development of biomimetic materials that can provide an appropriate microenvironment for tissue development. These materials have been constructed into devices that can be used as vehicles for delivery of cells, growth factors and DNA. In this review, different mechanisms of drug delivery are addressed in the context of novel approaches to reconstruct and engineer oral-and tooth-supporting structures, namely the periodontium and alveolar bone.

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Section: Growth Factors For Wound Repairmentioning

confidence: 99%

Growth factor delivery for oral and periodontal tissue engineering

Kaigler

Cirelli

Giannobile

2006

Expert Opinion on Drug Delivery

164

153

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“…Finn et al [20] Évaluation Concernant les 7 études précliniques, il y avait six modèles canins [22,25,[32][33][34][35] et un modèle chez le primate [36]. Six études concernaient l'utilisation d'éponges de collagène implantées seules ou en association avec des facteurs de croissance dans la régénération de défauts osseux créés chirurgicalement [25,[32][33][34][35][36]. Dans trois études, la régénération alvéolaire était évaluée en fonction de différentes concentrations de rhBMP-2 [34], de BMP6 [33], ou de rhGDF5 [32], avec une éponge de collagène comme vecteur.…”

Section: Utilisation Des éPonges De Collagène Pour La Régénération Osunclassified

“…Enfin, une étude évaluait la régénération de l'os alvéolaire d'un défaut parodontal en présence de rhBMP-2/ACS, rhBMP-2/PCa, ACS, et PCa [36]. Le phosphate de calcium (PCa) était synthé-tique αBSM et il servait de vecteur au même titre que les éponges de collagène dans cette étude.…”

Section: Utilisation Des éPonges De Collagène Pour La Régénération Osunclassified

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Intérêt des éponges de collagène pour prévenir la résorption osseuse alvéolaire post-extractionnelle : revue systématique de la littérature

Blanchy

Babilotte

Fénelon

et al. 2016

Med Buccale Chir Buccale

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Résumé -Introduction :La cicatrisation alvéolaire post-extractionnelle est accompagnée systématiquement d'une résorption osseuse plus ou moins importante selon les sites anatomiques et la pathologie initiale. Cette résorption osseuse peut parfois compromettre la mise en place d'implants dentaires. L'objectif de cette revue systématique de la littérature était d'évaluer si les éponges de collagène permettaient de limiter cette résorption osseuse. Matériels et méthodes : Les bases de données Medline et Pubmed ont été consultées pour la période 1986-2015. Résultats : Les études comparant les éponges de collagène à une cicatrisation naturelle n'ont pas montré de différence significative en ce qui concerne la cicatrisation alvéolaire. En revanche, les études comparant l'implantation d'une éponge de collagène comme vecteur de facteurs de croissance à une éponge de collagène seule montraient un effet positif des facteurs de croissance pour corriger un défaut osseux parodontal ou pour limiter la résorption post-extractionnelle. Discussion : Il n'y a pas d'intérêt à placer une éponge de collagène seule dans une alvéole d'extraction pour limiter la résorption osseuse. En revanche, la mise en place dans l'alvéole d'une éponge de collagène associée à des facteurs de croissance permet de maintenir la hauteur et la largeur de la crête alvéolaire. Conclusion : Les éponges de collagène doivent être utilisées uniquement comme des hémostatiques locaux après une extraction dentaire. Rien n'indique dans la littérature que ces éponges pourraient avoir un rôle dans le maintien du volume osseux alvéolaire.Abstract -Use of acellular collagen sponges to prevent post-extraction alveolar bone resorption: systematic review of the literature. Introduction: Alveolar bone healing following dental extraction is usually accompanied by a resorption of alveolar bone. This resorption of alveolar bone may hinder the insertion of dental implants. The aim of this literature review was to evaluate whether acellular collagen sponge (ACS) grafting could limit alveolar bone resorption and maintain alveolar bone volume after dental extraction. Materials and Methods: The Medline and Pubmed databases were searched for the period 1986-2015. Results: Studies comparing ACS grafting with natural healing did not show any significant differences concerning alveolar bone healing and bone volume preservation. Experiments comparing the implantation of ACS alone versus ACS loaded with growth factors such as rh-BMP2 showed better results using rh-BMP2 for guided periodontal regeneration and post-extraction alveolar bone volume preservation. Discussion: This systematic review of the literature shows that there is no evidence that grafting a collagen sponge inside an alveolar socket would limit alveolar bone resorption. On the other hand, the insertion of a collagen sponge loaded with growth factors (such as rhBMP2) allows maintaining the height and width of the alveolar ridge. Conclusion: Acellular collagen sponges must be used as a local haemostatic agent. They have n...

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“…Blumenthal ve ark. 38 , rh BMP-2'nin periodontal rejenerasyonu arttırdığını gözlemlemişlerdir. Iohara ve ark.…”

Section: Introductionunclassified

Traditional and Current Treatment Methods from Apexification to Apexogenesis

Ceyhan¹,

Akdik²

2018

EÜ Dişhek Fak Derg

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ÖZETBu derlemenin amacı; herhangi bir sebeple canlılığını kaybetmiş, olgunlaşmamış, genç daimi dişlerin gelişimlerinin tamamlanabilmesi için çocuk diş hekimliğinde rutin olarak kullanılan geleneksel tedavi yöntemleri ve günümüzde sıklıkla kullanılmaya başlanan rejeneratif yöntemleri ele almak ve konu ile ilgili yapılmış çalışmaları sunarak gelecekteki klinik uygulamalara katkı sağlamaktır. Nekrotik genç daimi dişlerin kök gelişiminin sağlanması için farklı materyaller kullanılarak uygulanan apeksifikasyon tedavisinden uzun yıllardır yararlanılmaktadır. Bu yöntemin bazı dezavantajları nedeniyle rejeneratif tedavi yöntemleri gündeme gelmeye başlamıştır. Rejeneratif prosedürlerin temelini oluşturan doku mühendisliği, fonksiyonunu kaybetmiş doku ya da organların yeniden restorasyonuna odaklanmakta olup bu konuda yapılan çalışmalar diş hekimliğinin birçok alanında ümit verici sonuçlar elde edildiğini göstermektedir. İlerleyen teknoloji, yüksek hızlı el aletlerinin geliştirilmesinden biyolojik onarım materyallerine kadar diş hekimliği uygulamaları üzerinde önemli, süregelen bir etkiye sahiptir. Doku mühendisliği uygulamalarının günümüzde kullanılan diş tedavilerine alternatif olabilmesi açısından, hekimlerin bu uygulamalar hakkında detaylı bilgilere sahip olmaları ve araştırmalar yaparak uzun dönem sonuçlarını sunmaları önem arz etmektedir.

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Effect of Surgical Implantation of Recombinant Human Bone Morphogenetic Protein‐2 in a Bioabsorbable Collagen Sponge or Calcium Phosphate Putty Carrier in Intrabony Periodontal Defects in the Baboon

Abstract: The results of this study support the use of rhBMP-2 to enhance periodontal regeneration of intrabony periodontal defects. While this novel technology holds promise, refinement in carrier systems may provide the key to enhancement of the regenerative potential.

Cited by 48 publications

References 53 publications

Growth factor delivery for oral and periodontal tissue engineering

Growth factor delivery for oral and periodontal tissue engineering

Intérêt des éponges de collagène pour prévenir la résorption osseuse alvéolaire post-extractionnelle : revue systématique de la littérature

Traditional and Current Treatment Methods from Apexification to Apexogenesis

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