Effect of Surgical and Chemical Adrenergic Denervation on Vascular Responses

Haeusler, G.; Haefely, W; Huerlimann, A.

doi:10.1159/000391906

Cited by 10 publications

(4 citation statements)

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“…In perfused mesenteric blood vessels from rats sympathectomized from birth with higher doses of 6-hydroxydopamine the magnitude of the vasoconstrictor response to injected noradrenaline was less than or equal to the response of normal vessels over a range of doses. This result is similar to that obtained by Haeusler et al (1971) in mesenteric arteries from adult rats treated with 6-hydroxydopamine for at least 10 days before the experiment. They found no evidence for the development of postjunctional supersensitivity in chronically denervated mesenteric blood vessels.…”

Section: Discussionsupporting

confidence: 90%

“…Whether acute or moderately long-term sympathectomy sensitizes blood vessels to the vasoconstrictor effects of noradrenaline is controversial (Haeusler, Haefely & Huerlimann, 1971). In perfused mesenteric blood vessels from rats sympathectomized from birth with higher doses of 6-hydroxydopamine the magnitude of the vasoconstrictor response to injected noradrenaline was less than or equal to the response of normal vessels over a range of doses.…”

Section: Discussionmentioning

confidence: 99%

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Long‐lasting peripheral and central effects of 6‐hydroxydopamine in rats

Clark¹,

Laverty²,

Phelan

1972

British J Pharmacology

151

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Summary1. In newborn rats treated with 6-hydroxydopamine hydrobromide (6-OHDA) (50-150 mg/kg on 5-7 days) a widespread and long-lasting dose related sympathectomy was demonstrated. 2. When rats given 6-hydroxydopamine (100 mg/kg, seven treatments) in the neonatal period were killed at 10 weeks the concentration of noradrenaline (NA) in the heart, mesentery and vas deferens was significantly reduced. There was no alteration in the catecholamine content of the adrenal glands. 3. The amplitude of the responses of perfused mesenteric arteries from 6-hydroxydopamine treated rats to intra-arterial noradrenaline was not increased, compared with controls, but the duration of responses was increased. 4. 6-Hydroxydopamine given to newborn rats caused a long-lasting depletion of noradrenaline in three of the five regions of the central nervous system (cortex, cerebellum and spinal cord) studied. The concentration of noradrenaline in the pons-medulla was increased, but in the thalamic region was unchanged. The treated rats showed significantly lower exploratory activity. 5. Treatment of newborn rats with 6-hydroxydopamine thus has striking and long-lasting effects on peripheral and central adrenergic systems.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Long‐lasting peripheral and central effects of 6‐hydroxydopamine in rats

Clark¹,

Laverty²,

Phelan

1972

British J Pharmacology

151

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“…In previous studies it has generally been found that treatment with 6-OHDA induces little or no catecholamine supersensitivity in arterial vessels (Haeusler, Haefely & Thoenen, 1969;Haeusler, Haefely & HUrlimann, 1971;Finch et al 1973; but see Shibata et al 1972). There have been no previous studies on catecholamine sensitivity of veins after treatment with 6-OHDA.…”

Section: Discussionmentioning

confidence: 99%

Regenerations of the noradrenergic innervation of the cardiovascular system of the chick following treatment with 6‐hydroxydopamine

Bennett¹,

Malmfors²

1974

The Journal of Physiology

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SUMMARY1. Fluorescence histochemical and pharmacological studies were made of the noradrenergic innervation of inferior venae cavae and left atria from 2-and 6-week-old chicks before, and following, treatment with 6-hydroxydopamine.2. Noradrenergic nerves in the younger animals appeared to be relatively resistant to the toxic effects of 6-hydroxydopamine.3. In the older animals, the time course of recovery from the effects of 6-hydroxydopamine appeared to reflect the rate of regeneration of destroyed noradrenergic nerves.4. Marked presynaptic supersensitivity to adrenaline and noradrenaline was observed in left atria and inferior venae cavae following treatment with 6-hydroxydopamine.

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“…a virtually complete adrenergic denervation of arterial blood vessels as it does in most of the other adrenergically innervated peripheral tissues. The high residual noradrenaline content (50% of controls) found in the mesentery after treatment of adult rats with 6-OHDA (Haeusler & Haefely, 1970;Haeusler, Haefely & Huerlimann, 1971) probably represents noradrenaline located in the 'long nonterminal sympathetic nerve fibres which accompany the mesenteric blood vessels and which are not destroyed by 6-OHDA. The absence of a supersensitivity to exogenous noradrenaline observed in the present experiments in the isolated renal artery preparation after administration of 6-OHDA to adult rats does not necessarily militate against the completeness of the adrenergic denervation.…”

Section: Discusionmentioning

confidence: 99%

A comparison of the effects of chemical sympathectomy by 6‐hydroxydopamine in newborn and adult rats

Finch

Haeusler

Thoenen

1973

British J Pharmacology

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Summary1. The effects of chemical sympathectomy with 6-hydroxydopamine (6-OHDA) on the cardiovascular system of the rat were compared in, (a) 10-weekold rats treated during the first 14 days after birth with 150 ,ug/g sub--cutaneously, and (b) adult rats injected intravenously with 2 x 50 mg/kg on day 1 and 2 x 100 mg/kg on day 7 and the experiments performed on day 8. 2. Intravenous administration of 6-OHDA to adult rats almost completely abolished the pressor responses to stimulation of the entire sympathetic outflow in the pithed rat, the contractions of the lower eyelid to stimulation of the cervical sympathetic trunk and the vasconstrictor responses produced by periarterial nerve stimulation of the isolated renal artery preparation. Pressor responses to physostigmine and to tyramine were markedly reduced or abolished in anaesthetized and pithed rat preparations, respectively. 3. In corresponding experiments, 10-week-old rats treated as newborns with 6-OHDA; showed a marked reduction in the stimulation-induced pressor responses and contractions of the lower eyelid, but completely normal vasoconstrictor responses to periarterial nerve stimulation of the isolated perfused renal artery were obtained. The pressor responses to physostigmine were slightly reduced but the tyramine responses were unchanged. 4. Treatment with 6-OHDA at birth caused an almost complete and longlasting noradren-aline depletion in the heart, spleen, salivary glands and ileum but only a partial depletion in the mesentery from 10-week-old rats. These low noradrenaline levels showed no recovery in rats up to an age of 4 months. The tyrosine hydroxylase activity in both the cervical and stellate ganglia from 10-week-old rats was markedly reduced by treatment with 6-OHDA after birth. 5. Injections of 6-OHDA after birth produce an almost complete and permanent sympathectomy of various adrenergically innervated organs in the rat.

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Effect of Surgical and Chemical Adrenergic Denervation on Vascular Responses

Cited by 10 publications

References 0 publications

Long‐lasting peripheral and central effects of 6‐hydroxydopamine in rats

Long‐lasting peripheral and central effects of 6‐hydroxydopamine in rats

Regenerations of the noradrenergic innervation of the cardiovascular system of the chick following treatment with 6‐hydroxydopamine

A comparison of the effects of chemical sympathectomy by 6‐hydroxydopamine in newborn and adult rats

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