Effect of surfactant on the characteristics of biodegradable microcapsules

Abstract

The objective of this project was to evaluate the effect of several lipophilic surfactants on the characteristics of PLGA microcapsules. BSA was used as a model peptide. Seven different lipophilic surfactants were used and each of the surfactants was used at three different concentrations, 0.1, 0.5 and 1% (w/w), respectively. The microcapsules were prepared using the double emulsion solvent evaporation technique. The microcapsules were all spherical in shape with a smooth surface. The median size of the microcapsules varied between 4 and 49 microm. The zeta potential of the microcapsules varied between -26 and -43 mV. The efficiency of encapsulation varied between 8 and 45%. Efficiency of encapsulation appears to be dependant on both the type and concentration of the surfactant. Cumulative percent of BSA released up to 35 days varied from 18 to 78%. In conclusion, the physical characteristics of the microcapsules do not appear to be greatly affected by the type of surfactant. All of the samples appear to show polydispersity in their particle sizes. Particle charge depended on both the type and concentration of the surfactant. The overall dissolution of these microcapsules was very slow.

Encapsulation and release ofα-chymotrypsin from poly(glycerol adipate-co-ω-pentadecalactone) microparticles

“…The choice of stabiliser very much depends on the type of emulsion to be stabilised. The effects of surfactants are not limited to the preparation procedure of the particles, but also have an influence on the characteristics of the particles and hence release of active (Graves et al, 2005).…”

Intrinsic Tween 20 Improves Release and Antilisterial Properties of Co-encapsulated Nisin and Thymol

“…When Tween 20 was used at a 10% and 50% molar percentage of the encapsulated β-lactoglobulin, the burst release (in 2 min) reduced to 16% and 1%, respectively, from 23% for the treatment without Tween 20. 31 In another study, 32 different types of surfactants, that is, zwitterionic, anionic, and nonionic, were used at different levels to study encapsulation and release properties of bovine serum albumin (BSA). The EE of BSA and percentages of its release over time were observed to increase, decrease, or be unaffected with an increase in surfactant level used at 0.1À1% mass of PLGA, depending on the specific surfactant.…”

Drug release from PLGA particles with polyelectrolyte coating

“…PLGA particle and film fabrication PLGA microparticles and nanoparticles were fabricated similarly using either the o/w or the w/o/w emulsion followed by evaporation of the solvent in the oil phase, as is amply available in the literature. [141][142][143][144][145][146] Due to its variety, the exact details of fabrication of each type of particles are described in the corresponding chapter. Suffice it to say that the primary difference between micro-and nanoparticles is the emulsion power of the final emulsion: greater with nanoparticles, and smaller with microparticles.…”