Effect of Surfactant Mixing on Partitioning of Model Hydrophobic Drug, Naproxen, between Aqueous and Micellar Phases

Abstract

Mixed surfactants may improve the performance of surfactant-enhanced solubilization of drugs and thus can serve as the tool for increased bioavalaibility, controlled drug release, and targeted delivery. Solubilization of Naproxen by micellar solutions at 25 degrees C using single and mixed surfactant systems was measured and compared. Solubilization capacity determined with spectrophotometry and tensiometry has been quantified in terms of molar solubilization ratio, micelle-water partition coefficient, and locus of solubilization. Cationic surfactants exhibited higher solubilization capacity than nonionics and anionics, the efficiency increasing with chain length. Mixing effect of surfactants on mixed micelle formation and solubilization efficiency has been discussed in light of regular solution approximation (RSA). Equimolar cationic-nonionic surfactant combinations showed better solubilization capacity than pure cationics or nonionics, which, in general, increased with increase in hydrophobic chain length. Equimolar cationic-nonionic-nonionic ternary surfactant systems exhibited intermediate solubilization efficiency between their single and binary counterparts. Use of RSA has been extended, with fair success, to predict the partition coefficient of ternary surfactant systems using data from binary mixtures. The theoretical micelle-water partition coefficients calculated from the geometric mean equation compared well with experimental values. Locus of solubilization of NAP in different micellar solutions was probed by UV-visible spectroscopy.

Effects of surfactant micelles on solubilization and DPPH radical scavenging activity of Rutin

“…Among single ionic surfactant systems, the solubilization is least efficient in SDS as evident from the values of MSR, a possible consequence of electrostatic repulsion between anionic Rutin and negatively charged SDS head groups. Similar results have been reported in solubilization studies of Ibuprofen [53], Sulfanilamide [54] and Naproxen [55]. However, the extent of solubilization is observed to increase with concentration of SDS through hydrophobic interactions due to increase in micelle concentration.…”

Enhanced soil retention for o-nitroaniline by the addition of a mixture of a cationic surfactant (Cetyl Pyridinium Chloride) and a nonionic surfactant (Polyethylene Glycol Mono-4-nonylphenyl Ether)

“…However, at an added dose of CPC above 15,000 mg L −1 , the added P0707 continually decreased the K * d values of o-nitroaniline. As described in equation 1, the decrease of K * d values of o-nitroaniline could be attributed to the forming of mixed micelles in solution, which remains o-nitroaniline in solution by solubilization [26][27][28]. The maximum K * d value of o-nitroaniline is approximately 144 mL g −1 , which is appeared at the added P0707 and CPC dose of 6000 and 10,500 mg L −1 respectively (Fig.…”

“…Giving consideration to the different adsorption mechanisms of cationic and nonionic surfactants on soils and clays, cationic and nonionic surfactants can be expected to adsorb on soils and clays simultaneously without sorptive competition and thus to provide higher organic matter content for sorption. Moreover, in the mixed cationic-nonionic surfactant systems, mixed micelles might form, which may differ significantly from the micelles of individual surfactant and exhibit a number of synergistic advantages over the use of a single surfactant type [26][27][28][29][30][31]. For example, mixed micelles of cationic-nonionic surfactant mixtures may be more effective for partition of organic contaminants than the micelles of individual surfactants [26][27][28].…”

“…Moreover, in the mixed cationic-nonionic surfactant systems, mixed micelles might form, which may differ significantly from the micelles of individual surfactant and exhibit a number of synergistic advantages over the use of a single surfactant type [26][27][28][29][30][31]. For example, mixed micelles of cationic-nonionic surfactant mixtures may be more effective for partition of organic contaminants than the micelles of individual surfactants [26][27][28]. If mixed micelle-like structures (mixed hemi-micelles) formed on soil/clay surface, it can be expected that the organic phase derived from the soil adsorbed mixed hemi-micelles may be more effective for sorption of organic contaminants than the organic phase derived from the adsorbed single surfactant.…”

Effect of L64 on the Phase Behavior of 1‐Dodecyl‐3‐methylimidazolium Chloride/Water System

“…1,2 Especially, the aggregation behaviors and interactions between nonionic surfactant and cationic surfactant have been paid much attention. [3][4][5][6][7][8] Li et al 3 investigated the interaction between the cationic surfactant tetradecyltrimethylammonium bromide (TTAB) and the Pluronic triblock copolymer F127 in water by electromotive force, isothermal titration calorimetry (ITC), differential scanning calorimetry (DSC), and light scattering techniques. They showed that F127 micelles change to mixed F127/TTAB micelles, further to F127/micellar TTAB complex with increasing of TTAB concentration at 35 , and the micellization b ℃ ehavior was emphasized.…”