Effect of surfactant micelles on solubility and spectral characteristics of 2,2’-bibenzimidazole

Abstract

The solubilization capacity of surfactants of different types was quantitatively characterized by spectrophotometry toward 2,2´ bibenzimidazole (BBI), whose derivatives possess a wide range of pharmacological activity. 2,2´ Bibenzimidazole solubilized by sodium dodecyl sulfate micelles is characterized by a high molar absorption coefficient (9400 mol -1 L cm -1 ) at the absorbance maximum (342 nm at pH 4-10), which may serve as a basis for the development of procedures for analytical monitoring of the BBI content in aqueous solutions and biosystems. The ability of surfactants to enhance the solubility of BBI in water and, as a consequence, to increase its bioavailability in the series sodium dodecyl sulfate < cetyltrimethylammonium bromide < Tween 80.