Effect of surface roughness on initial responses of osteoblast-like cells on two types of zirconia

Yamashita, Daisuke; Machigashira, Miho; Miyamoto, Mari; Takeuchi, Hironobu; Noguchi, Kazuyuki; Izumi, Yuichi; Ban, Seiji

doi:10.4012/dmj.28.461

Cited by 143 publications

(104 citation statements)

References 36 publications

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“…In contrast, Yamashita et al have studied attachment of osteoblast-like cells on 2 kinds of ceramics and reported that surface condition had no effect on initial attachment because the specimen surface was covered by chemically stable oxide [43]. Price et al have made composites of ceramics and carbon nanofibers and reported that the finer surface of the specimens increased the attachment area of osteoblasts, and the number of attached cells increased with an increase in the addition of carbon nanofibers [44,45].…”

Section: Discussionmentioning

confidence: 99%

Biocompatibility and Bone Tissue Compatibility of Alumina Ceramics Reinforced with Carbon Nanotubes

et al. 2012

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Aims: The addition of carbon nanotubes (CNTs) remarkably improves the mechanical characteristics of base materials. CNT/alumina ceramic composites are expected to be highly functional biomaterials useful in a variety of medical fields. Biocompatibility and bone tissue compatibility were studied for the application of CNT/alumina composites as biomaterials.Methods & results: Inflammation reactions in response to the composite were as mild as those of alumina ceramic alone in a subcutaneous implantation study. In bone implantation testing, the composite showed good bone tissue compatibility and connected directly to new bone. An in vitro cell attachment test was performed for osteoblasts, chondrocytes, fibroblasts, and smooth muscle cells, and CNT/alumina composite showed cell attachment similar to that of alumina ceramic.Discussion & conclusion: Owing to proven good biocompatibility and bone tissue compatibility, the application of CNT/alumina composites as biomaterials that contact bone, such as prostheses in arthroplasty and devices for bone repair, are expected.4

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Section: Discussionmentioning

confidence: 99%

Biocompatibility and Bone Tissue Compatibility of Alumina Ceramics Reinforced with Carbon Nanotubes

et al. 2012

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“…In recent studies, it was shown that by introducing surface roughness in 3Y-TZP, the cell response was similar to titanium and alumina, concluding that roughened zirconia surface represents an appropriate substrate for proliferation and spreading of osteoblastic cells (Bächle et al, 2007;Wenz et al, 2008;Yamashita et al, 2009). It was also reported that zirconia dental implants with acid etched surface (CeraRoot implants with 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 4 ICE™ surface) showed a similar or higher success rate as for Titanium implants after 5 years of follow-up study (Oliva et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Surface roughened zirconia: towards hydrothermal stability

Camposilvan

Flamant

Anglada

2015

Journal of the Mechanical Behavior of Biomedical Materials

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Surface roughness is needed in several yttria-stabilized zirconia components used in restorative dentistry for osseointegration or adhesion purposes. This can be achieved by different treatments, which may also modify the microstructure of the surface. Among them, sandblasting and chemical etching are widely used, but their effect on hydrothermal aging of zirconia is not fully understood. In the present work, the zirconia long-term stability of rough surfaces prepared by these techniques is analyzed and a method is proposed for preventing hydrothermal aging while maintaining the original surface appearance and mechanical properties. The method involves pressure infiltration of a Cerium salt solution on the roughened surfaces followed by a thermal treatment. The solution, trapped by surface defects and small pores, is decomposed during thermal treatment into Cerium oxide, which is diffused at high temperature, obtaining Ce co-doping in the near-surface region.In addition, the microstructural changes induced in the near-surface by sandblasting or chemical etching are removed by the thermal treatment together with surface defects. No color modification was observed and the final roughness parameters were in the range of existing implants of proved good osseointegration. The aging resistance of Ce co-doped materials was strongly enhanced, showing the absence of aging after artificial degradation, increasing in this way the surface mechanical integrity.The proposed treatment is easily applicable to the current manufacturing procedures of zirconia dental posts, abutments, crowns and dentures, representing a solution to hydrothermal aging in these and other biomedical applications.

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“…A number of studies have described the early stages of osteoblast-zirconia attachment, proliferation, differentiation and activity [10][11][12] . The initial attachment of fibroblasts, assuming soft tissue adhesion, on zirconia or Ti discs has also been investigated 13,14) , and these studies have confirmed the similar biological responses of each type of cell on each material.…”

Section: Introductionmentioning

confidence: 99%

Initial attachment of human oral keratinocytes cultured on zirconia or titanium

et al. 2012

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Initial attachment of human oral keratinocytes (HOKs) cultured on mirror-surfaced commercially pure titanium (Ti) or yttriastabilized tetragonal zirconia polycrystals (TZP) was investigated. Numbers of viable attached HOKs, their mRNAs and proteins expression of laminin γ2 and integrin β4 were evaluated using the WST-1 assay, quantitative real-time PCR and enzyme-linked immunosorbent assay, respectively. Localization of laminin γ2 and integrin β4 was observed using immunofluorescent staining. Cell spreading was evaluated by measuring the perimeter of actin on fluorescent stained images, and cell morphology was examined using scanning electron microscopy. At 1 h TZP elicited less of initial attachment than Ti in terms of mRNAs expression and proteins expression of laminin γ2 and integrin β4 (p<0.05). However, at 48 h TZP was showed similar initial attachment in comparison to Ti. Therefore, it was suggested that TZP has a potential to form epithelial attachment like Ti.

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Effect of surface roughness on initial responses of osteoblast-like cells on two types of zirconia

Cited by 143 publications

References 36 publications

Biocompatibility and Bone Tissue Compatibility of Alumina Ceramics Reinforced with Carbon Nanotubes

Biocompatibility and Bone Tissue Compatibility of Alumina Ceramics Reinforced with Carbon Nanotubes

Surface roughened zirconia: towards hydrothermal stability

Initial attachment of human oral keratinocytes cultured on zirconia or titanium

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