Functionally Graded Materials (FGMs) is a promising engineering material, which is highly desirable in extreme environments of aerospace, nuclear and bio-implants. Although the surface accuracy and quality of 3D printed Ni-Fe FGMs can meet most application scenarios, it still requires post-cutting treatment especially in nuclear industry. The FGMs, with the gradient of mechanical property, is a new type of di cult-to-cut material. However, no ready-made post milling process can be referred. The poor machined surface quality induced by severe tool wear still cannot be handled even with textured tool under Minimum Quantity Lubrication (MQL). In this paper, the mechanical properties and machinability of the Ni-Fe FGMs as well as its 5 isotropic component 304L x IN625 y were rstly studied and correlated. Then, two milling parameter selection strategies were proposed by minimum milling force and by minimum surface roughness, corresponding to strategy I and strategy II. The results show that severe tool breakage occurs when strategy I is adopted. On the contrary, tool undergone continuous reciprocating cycles of bonding, coating peeling, re-bonding, re-peeling when strategy II is adopted. Un this circumstance, strategy II can reduce tool ank wear by 40.1% regarding to the synergistic effect of micro-texture and MQL, which is a prospective method to solve the low tool durability during machining of 3D printed Ni-Fe FGMs.