Effect of surface modification on optical and electronic properties of graphene quantum dots

Rani, Priya; Dalal, Ranjeet; Srivastava, Sunita

doi:10.1016/j.apsusc.2022.155379

Cited by 30 publications

(17 citation statements)

References 35 publications

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“…The hydrodynamic diameter was about 228 nm (Figure b) and the zeta potential was around −21.6 mV after being fully coated with PDA. In addition, the quantum yield (QY) of mSZ NPs was calculated according to Equation : QY = Ne / Na ≈ AUFl / AUAb where Ne and Na are the numbers of emitted and absorbed photons, respectively. AUFl and AUAb represent the areas under the fluorescence emission curve after ultrasonication (Figure e) and the absorption curve (Figure i), which were about 94.4 and 391.5, respectively.…”

Section: Resultsmentioning

confidence: 99%

Ultrasound-Chargeable Persistent Luminescence Nanoparticles to Generate Self-Propelled Motion and Photothermal/NO Therapy for Synergistic Tumor Treatment

Zhang,

Yan,

Cao

et al. 2023

ACS Nano

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Cancer phototherapy indicates advantages in ease of manipulation, negligible drug resistance, and spatiotemporal control but is confronted with challenges in tumor cell accessibility and intermittent light excitation. Herein, we propose a strategy with persistent luminescence (PL)-excited photothermal therapy (PTT), concurrent thermophoresispropelled motion, and PL-triggered NO release, where PL emission is chargeable by ultrasonication for readily applicable to deep tumors. Mechanoluminescent (ML) nanodots of SrAl 2 O 4 :Eu 2+ (SAOE) and PL nanodots of ZnGa 2 O 4 :Cr 3+ (ZGC) were deposited on mesoporous silicates to obtain mSZ nanoparticles (NPs), followed by partially coating with polydopamine (PDA) caps and loading NO donors to prepare Janus mSZ@PDA-NO NPs. The ML emission bands of SAOE nanodots overlap with the excitation band of ZGC, and the persistent near-infrared (NIR) emission could be repeatedly activated by ultrasonication. The PL emission acts as an internal NIR source to produce a thermophoretic force and NO gas propellers to drive the motion of Janus NPs. Compared with the commonly used intermittent NIR illumination at both 660 and 808 nm, the persistent motion of ultrasound-activated NPs enhances cellular uptake and long-lasting PTT and intracellular NO levels to combat tumor cells without the use of any chemotherapeutic drugs. The ultrasound-activated persistent motion promotes intratumoral accumulation and tumor distribution of PTT/NO therapeutics and exhibits significantly higher tumor growth inhibition, longer animal survival, and larger intratumoral NO levels than those who experience external NIR illumination. Thus, this study demonstrates a strategy to activate PL emissions and construct PLexcited nanomotors for phototherapy in deep tissues.

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Section: Resultsmentioning

confidence: 99%

Ultrasound-Chargeable Persistent Luminescence Nanoparticles to Generate Self-Propelled Motion and Photothermal/NO Therapy for Synergistic Tumor Treatment

Zhang,

Yan,

Cao

et al. 2023

ACS Nano

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“…This layer absorbs UV light and emits visible light, allowing for improved utilization of the sun's energy. [66,158,[214][215][216][217][218][219][220] For example, Lee et al reported the deposition of GQD layers onto the surface of a crystalline-silicon (c-Si) solar cell through the kinetic spraying of GQD suspensions (Figure 11a). At a nozzle scan speed of 30 mm/s, the layers effectively shifted the energy from UV wavelengths in the range between 300 and 420 nm to visible wavelengths (450-750 nm), resulting in an increase of the short circuit current density (J SC ) by 0.9 mA cm −2 and, consequently, an improvement in cell efficiency by 2.7%.…”

Section: Solar Cellsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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From Pristine to Heteroatom‐Doped Graphene Quantum Dots: An Essential Review and Prospects for Future Research

Kim

Hyeong

et al. 2023

Small

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Graphene quantum dots (GQDs) are carbon‐based zero‐dimensional materials that have received considerable scientific interest due to their exceptional optical, electrical, and optoelectrical properties. Their unique electronic band structures, influenced by quantum confinement and edge effects, differentiate the physical and optical characteristics of GQDs from other carbon nanostructures. Additionally, GQDs can be synthesized using various top‐down and bottom‐up approaches, distinguishing them from other carbon nanomaterials. This review discusses recent advancements in GQD research, focusing on their synthesis and functionalization for potential applications. Particularly, various methods for synthesizing functionalized GQDs using different doping routes are comprehensively reviewed. Based on previous reports, current challenges and future directions for GQDs research are discussed in detail herein.

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“…Graphene and its derivatives have great potential in a wide range of biomedical applications. , Recently, a set of rules were proposed for using graphene-based nanomaterials in the medical field as follows: (a) the use of discrete and small graphene sheets that macrophages in the body can effectively remove and internalize from the deposition sites, (b) the use of stable, hydrophilic, colloidal sheets to minimize their accumulation in the body, and (c) using biodegradable or chemically modified graphene that can be efficiently degraded. The biological response depends on lateral size, the number of layers, hydrophobicity, and surface functionalization. − The electronic properties and performance of graphene can be changed by surface modification with various functional groups. − …”

Section: Introductionmentioning

confidence: 99%

Graphene Oxide Hosting a pH-Sensitive Prodrug: An In Silico Investigation of Graphene Oxide-Based Nanovehicle toward Cancer Therapy

Zaboli

Raissi

Hashemzadeh

et al. 2023

ACS Appl. Bio Mater.

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Prodrug and drug delivery systems are two effective strategies for improving the selectivity of chemotherapeutics. Herein, via molecular dynamics (MD) simulation and free energy calculation, the effectiveness of the graphene oxide (GO) decorated with the pH-sensitive prodrug (PD) molecules in cancer therapy is investigated. PEI–CA–DOX (prodrug) was loaded onto the GO surface, in which the hydrogen bonding and pi–pi stacking interactions play the main role in the stability of the GO–PD complex. Due to the strong interaction of GO and PD (about −800 kJ/mol), the GO–PD complex remains stable during the membrane penetration process. The obtained results confirm that GO is a suitable surface for hosting the prodrug and passing it through the membrane. Furthermore, the investigation of the release process shows that the PD can be released under acidic conditions. This phenomenon is due to the reduction of the contribution of electrostatic energy in the GO and PD interaction and the entry of water into the drug delivery system. Moreover, it is found that an external electrical field does not have much effect on drug release. Our results provide a deep understanding of the prodrug delivery systems, which helps the combination of nanocarriers and modified chemotherapy drugs in the future.

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Effect of surface modification on optical and electronic properties of graphene quantum dots

Cited by 30 publications

References 35 publications

Ultrasound-Chargeable Persistent Luminescence Nanoparticles to Generate Self-Propelled Motion and Photothermal/NO Therapy for Synergistic Tumor Treatment

Ultrasound-Chargeable Persistent Luminescence Nanoparticles to Generate Self-Propelled Motion and Photothermal/NO Therapy for Synergistic Tumor Treatment

From Pristine to Heteroatom‐Doped Graphene Quantum Dots: An Essential Review and Prospects for Future Research

Graphene Oxide Hosting a pH-Sensitive Prodrug: An In Silico Investigation of Graphene Oxide-Based Nanovehicle toward Cancer Therapy

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