Effect of surface coating on the toxicity of silver nanomaterials on human skin keratinocytes

Lu, Wentong; Senapati, Dulal; Wang, Shuguang; Tovmachenko, O. G.; Singh, Anant Kumar; Yu, Hongtao; Ray, Paresh Chandra

doi:10.1016/j.cplett.2010.01.027

Cited by 227 publications

(163 citation statements)

References 25 publications

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“…MHA@AgNPs, indicating the surface coating could obviously mediate the antibacterial activities of AgNPs. The surface coating effect that was previously reported indicated that citrate-coated AgNPs exerted higher toxicities when compared to those coated with biodegradable polymer, 29 although no differences were observed between AgNPs with polyvinylpyrrolidone or oleic acid coatings in an earthworm study. 30 The antibacterial order observed was exactly consistent with the trend of silver ion release from these AgNPs (Figure 2).…”

mentioning

confidence: 64%

Surface ligand controls silver ion release of nanosilver and its antibacterial activity against <em>Escherichia coli</em>

Long¹,

Hu²,

Yan³

et al. 2017

IJN

120

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Understanding the mechanism of nanosilver-dependent antibacterial activity against microorganisms helps optimize the design and usage of the related nanomaterials. In this study, we prepared four kinds of 10 nm-sized silver nanoparticles (AgNPs) with dictated surface chemistry by capping different ligands, including citrate, mercaptopropionic acid, mercaptohexanoic acid, and mercaptopropionic sulfonic acid. Their surface-dependent chemistry and antibacterial activities were investigated. Owing to the weak bond to surface Ag, short carbon chain, and low silver ion attraction, citrate-coated AgNPs caused the highest silver ion release and the strongest antibacterial activity against Escherichia coli , when compared to the other tested AgNPs. The study on the underlying antibacterial mechanisms indicated that cellular membrane uptake of Ag, NAD + /NADH ratio increase, and intracellular reactive oxygen species (ROS) generation were significantly induced in both AgNP and silver ion exposure groups. The released silver ions from AgNPs inside cells through a Trojan-horse-type mechanism were suggested to interact with respiratory chain proteins on the membrane, interrupt intracellular O 2 reduction, and induce ROS production. The further oxidative damages of lipid peroxidation and membrane breakdown caused the lethal effect on E. coli . Altogether, this study demonstrated that AgNPs exerted antibacterial activity through the release of silver ions and the subsequent induction of intracellular ROS generation by interacting with the cell membrane. The findings are helpful in guiding the controllable synthesis through the regulation of surface coating for medical care purpose.

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mentioning

confidence: 64%

Surface ligand controls silver ion release of nanosilver and its antibacterial activity against <em>Escherichia coli</em>

Long¹,

Hu²,

Yan³

et al. 2017

IJN

120

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“…These results suggested reversible toxicity of Ag NPs and a transient discoloration of exposed skin. Lu et al [38] reported the effect of surface coating on cyto, geno and photo-toxicity of silver nanomaterials of different shapes on human skin HaCaT keratinocytes. They demonstrated that coating of silver NPs with a biodegradable polymer prevents the toxicity of the power.…”

Section: Penetration Of Metal Npsmentioning

confidence: 99%

Skin penetration of inorganic and metallic nanoparticles

Wang

2014

J. Shanghai Jiaotong Univ. (Sci.)

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Nanotechnology is a rapidly growing science of producing and utilizing nano-sized particles. These nanomaterials are already having an impact on health care. Nowadays we are using nanoproducts in various fields, and this leads to direct and indirect exposure in human. Skin is the largest organ of the body and functions as the first-line barrier between the external environment and the internal organs of the human body. Then people worry about the nanoparticle (NP) small enough to penetrate the skin. The potential of solid NPs to penetrate the stratum corneum and to diffuse into underlying structures raises a considerable health and safety issue for their topical use. We review the current state of knowledge on the potential risk to human health presented by skin penetration of NPs nanotechnologies, and explore the robustness of current research strategies and directions to ensure the development of "safe" and publicly accepted nano-based products and technologies.

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“…Various applications of silver nanoparticles to vegetables (An, Zhang, Wang, & Tang, 2008;Costa, Conte, Buonocore, & Del Nobile, 2011;Fayaz, Balaji, Girilal, Kalaichelvan, & Tvenkatesan, 2009;Hu, Fanga, Yang, Ma, & Zhao, 2011;Zhang, Duan, & Shan, 2005) and dairy products (Incoronato, Conte, Buonocore, & Del Nobile, 2011) are reported in the literature. As toxicological features of silver nanoparticles are well known (Kiruba, S.C.G., Tharmaraj, Sironmanic, & Pitchumani, 2010;Lu et al, 2010), EU safety regulation limits silver amount to 0.05 mg Ag/kg of food (Fernandez et al, 2009). Thus, due to the safety concern, the use of food coatings as carriers of silver represents a viable approach to avoid the direct contact of nanoparticles with food (Gammariello, Conte, Buonocore, & Del Nobile, 2011;Incoronato et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Calcium-alginate coating loaded with silver-montmorillonite nanoparticles to prolong the shelf-life of fresh-cut carrots

Costa

Conte

Buonocore

et al. 2012

Food Research International

110

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Effect of surface coating on the toxicity of silver nanomaterials on human skin keratinocytes

Cited by 227 publications

References 25 publications

Surface ligand controls silver ion release of nanosilver and its antibacterial activity against <em>Escherichia coli</em>

Surface ligand controls silver ion release of nanosilver and its antibacterial activity against <em>Escherichia coli</em>

Skin penetration of inorganic and metallic nanoparticles

Calcium-alginate coating loaded with silver-montmorillonite nanoparticles to prolong the shelf-life of fresh-cut carrots

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