Effect of surface chemistry of polymeric nanoparticles on cutaneous penetration of cholecalciferol

Lalloz, Augustine; Bolzinger, Marie‐Alexandrine; Faivre, Jimmy; Latreille, Pierre‐Luc; Ac, Araceli García; Rakotovao, Cyrielle; Rabanel, Jean‐Michel; Hildgen, Patrice; Banquy, Xavier; Briançon, Stéphanie

doi:10.1016/j.ijpharm.2018.09.046

Cited by 20 publications

(7 citation statements)

References 72 publications

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“…This special structure allows liposomes convenient to carry and deliver drugs with difference characters from hydrophilic, hydrophobic to lipophilic, and they can even adsorb hydrophilic and lipophilic compounds simultaneously, thus making it more versatile [8]. The stability of liposomes whether in vitro or in vivo is influenced by NPs size, surface charge, lipid component, and surface modification (ligand or polymer), respectively [9]. Liposomes are usually modified on its surface to expand their fluidity and enhance drug delivery, and targeting as well.…”

Section: Ivyspringmentioning

confidence: 99%

Designing Nanoparticle-based Drug Delivery Systems for Precision Medicine

Yang¹,

Jia²,

Yang³

2021

Int. J. Med. Sci.

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Traditional drugs are facing bottlenecks of lower solubility, absorption, and especially the inefficient organs or cells targeting during the precision medicine era. It is urgently needed to discover and establish new methods or strategies to modify old drugs or create new ones against the above defects. With the support of nanotechnology, the solubility, absorption and targeting of traditional drugs were greatly improved by modifying and fabricating with various types of nanoparticles to some extent, though many shortages remain. In this mini-review we will focus on advances in several most commonly used nanoparticles, from their nature and design, to drug delivery system and clinical application, that they overcome heterogeneous barriers in precision medicine, thereby ultimately improve patient outcome overall.

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Section: Ivyspringmentioning

confidence: 99%

Designing Nanoparticle-based Drug Delivery Systems for Precision Medicine

Yang¹,

Jia²,

Yang³

2021

Int. J. Med. Sci.

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“…On the contrary, in the study of Lalloz et al (2018), it was not possible to penetrate VD into the epidermis through the intact pigskin with the use of poly(lactic acid) nanoparticles, regardless of the surface chemistry, although, the average particle size of nanoparticles was about 100 nm [66].…”

Section: Drug Delivery Systems For Application On the Skinmentioning

confidence: 99%

Drug Delivery Systems for Vitamin D Supplementation and Therapy

2019

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Vitamin D (VD) is a fat-soluble prohormone well known for its role in regulating calcium and phosphate metabolism. It has been clinically used for many years to prevent rickets in children, osteomalacia, and osteoporosis in adults. VD insufficiency is a common medical condition, and many supplements are available in the market in order to increase serum 25-hydroxy VD levels to recommended amounts. Over the course of the last decades, it has become increasingly clear that calcitriol, an active form of VD, regulates multiple cellular processes with effects on normal and malignant cell growth and differentiation, and on the immune and cardiovascular function. Increasing evidence supports the role of the VD system in cancer prevention and therapy. Due to many pleiotropic and beneficial effects in extra-skeletal disorders, VD has gained potential and become an interesting active for encapsulation into drug delivery systems. The purpose of this review is to present the diversity of drug delivery systems that have been reported for VD or VD derivatives in an orderly manner across the following categories: Oral administration, application on the skin, cancer prevention/therapy, and other diseases or routes of administration.

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“…According to the structure, polymeric nanocarriers are commonly divided into nanospheres, characterized by a solid structure in which the drug is dispersed in the polymer matrix, nanocapsules, which own a defined core in a liquid state and shell structure, and nanobubbles, spherical core/shell structures filled by a gas or vaporizable compounds [114]. Several authors proposed the application of nanospheres to enhance drug penetration, among them Lalloz et al [119] deeply studied the effect of the particles’ surface charge on skin penetration. In their work, vitamin D (logP = 7.5) was incorporated in purposely synthesized block copolymers by employing flash nanoprecipitation, a productive nanoparticle production technique (a technique that has been well-described, for example by Lavino et al [120]).…”

Section: Pharmaceutical Nanocarriers For Dermatological Applicationsmentioning

confidence: 99%

“…In their work, vitamin D (logP = 7.5) was incorporated in purposely synthesized block copolymers by employing flash nanoprecipitation, a productive nanoparticle production technique (a technique that has been well-described, for example by Lavino et al [120]). Permeation studies, conducted both on healthy and damaged pig skin, showed a limited effect of the nanoparticle surface charge on the healthy skin while particle polarity affected the release kinetics in the case of damaged skin tissue [119]. By employing a similar particle production methodology, our research group designed poly-ε-caprolactone (PCL) nanoparticles for the delivery of the strongly hydrophilic caffeine molecule (logP = −0.07).…”

Section: Pharmaceutical Nanocarriers For Dermatological Applicationsmentioning

confidence: 99%

“…In the work of Pereira [123] adapalene (logP = 8.5) loaded PCL nanocapsules were produced and topically applied: the high hydrophobicity of both carrier and drug facilitated diffusion in the SC but no further penetration was observed, making the system suitable for topical administration. Marto et al [70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88,89,90,91,92,93,94,95,96,97,98,99,100,101,102,103,104,105,106,107,108,109,110,111,112,113,114,115,116,117,118,119,120,121,122,123,124] incorporated an anti-inflammatory drug in starch-shelled nanoparticles by emulsion solvent evaporation method. The potential effectiveness of such topical formulation was evaluated both in vitro and in vivo on ra...…”

Section: Pharmaceutical Nanocarriers For Dermatological Applicationsmentioning

confidence: 99%

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Bio-Functional Textiles: Combining Pharmaceutical Nanocarriers with Fibrous Materials for Innovative Dermatological Therapies

et al. 2019

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In the field of pharmaceutical technology, significant attention has been paid on exploiting skin as a drug administration route. Considering the structural and chemical complexity of the skin barrier, many research works focused on developing an innovative way to enhance skin drug permeation. In this context, a new class of materials called bio-functional textiles has been developed. Such materials consist of the combination of advanced pharmaceutical carriers with textile materials. Therefore, they own the possibility of providing a wearable platform for continuous and controlled drug release. Notwithstanding the great potential of these materials, their large-scale application still faces some challenges. The present review provides a state-of-the-art perspective on the bio-functional textile technology analyzing the several issues involved. Firstly, the skin physiology, together with the dermatological delivery strategy, is keenly described in order to provide an overview of the problems tackled by bio-functional textiles technology. Secondly, an overview of the main dermatological nanocarriers is provided; thereafter the application of these nanomaterial to textiles is presented. Finally, the bio-functional textile technology is framed in the context of the different dermatological administration strategies; a comparative analysis that also considers how pharmaceutical regulation is conducted.

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Effect of surface chemistry of polymeric nanoparticles on cutaneous penetration of cholecalciferol

Cited by 20 publications

References 72 publications

Designing Nanoparticle-based Drug Delivery Systems for Precision Medicine

Designing Nanoparticle-based Drug Delivery Systems for Precision Medicine

Drug Delivery Systems for Vitamin D Supplementation and Therapy

Bio-Functional Textiles: Combining Pharmaceutical Nanocarriers with Fibrous Materials for Innovative Dermatological Therapies

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