Effect Of Surface Area Of Dialyzer Membrane On The Adequacy Of Haemodialysis

Chowdhury, NS; Islam, Fmm; Zafreen, Farzana; Begum, BA; Sultana, Nahid; Perveen, Shuhana; Mahal, M

doi:10.3329/jafmc.v7i2.10387

Cited by 7 publications

(7 citation statements)

References 5 publications

(6 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hemodialyzers with smaller surface area are known to give less adequate hemodialysis than those having larger surface area. is was shown in a study done in Bangladesh where they found that increasing the surface area of a dialyzer membrane (from 1.2 to 1.3 m 2 ) increased the adequacy of hemodialysis by 10.4% (by URR criteria) and 19.7% (by Kt/V criteria) [30]. Similarly, Panagoutsos et al showed that increasing the surface area of the dialyzer membrane from 1.15 m 2 ± 0.1 to 1.7 m 2 increased the Kt/V from 0.93 ± 0.19 to 1.55 ± 2.9 (p < 0.05) and URR from 52 ± 8% to 71 ± 7% (p < 0.05); that is, there was 66.7% and 36% increment in Kt/V and URR, respectively [31].…”

Section: Discussionmentioning

confidence: 90%

Adequacy of Hemodialysis and Its Associated Factors among Patients Undergoing Chronic Hemodialysis in Dar es Salaam, Tanzania

Somji

Ruggajo

Moledina

2020

International Journal of Nephrology

View full text Add to dashboard Cite

e worldwide prevalence of maintenance hemodialysis continues to rise. An adequate delivery of hemodialysis dose as measured by Kt/V or urea reduction ratio is a crucial determinant of clinical outcome for chronic hemodialysis patients. e aim of this study was to assess the adequacy of hemodialysis and its associated factors among patients undergoing chronic hemodialysis in Dar es Salaam. is was a cross-sectional study done on patients undergoing chronic hemodialysis in four dialysis centers in Dar es Salaam. Sociodemographic information and treatment characteristics were collected. Urea reduction rate and single-pool Kt/V were calculated to determine the adequacy of hemodialysis. e data were analyzed and any associated factors for inadequate hemodialysis were determined using a chi-square test and a logistic regression analysis. A total of 143 patients participated in the study. Males represented 65.7% of the study population. e mean age (±SD) was 51.7 ± 1.2 years. Only 34.3% (based on urea reduction ratio (URR)) and 40.6% (based on Kt/V) of patients received adequate hemodialysis. e univariate analysis showed that males were more likely to have inadequate dialysis (65.6% versus 48.0%, p � 0.048 based on Kt/V). Patients using hemodialyzers with dialyzer surface area less than 1.4 m 2 received significantly less hemodialysis dose than those with more than 1.4 m 2 (69.0% versus 41.2%, p � 0.02, by URR) (62.7% versus 35.3%, p � 0.03, by Kt/V criteria). Patients who had hemoglobin <10 g/dl received significantly inadequate hemodialysis dose as compared to patients with hemoglobin ≥10 g/dl by Kt/V criteria (69.8% versus 51.3%, p � 0.03). None of the factors acquired significance in the multivariate analysis. e proportion of patients receiving an adequate hemodialysis dose is low (34.3% based on URR and 40.6% based on Kt/V). Male gender, dialyzer surface area of <1.4 m 2 , and hemoglobin level of <10 g/dl were associated with an inadequate delivered dose of hemodialysis in the univariate analysis but not in the multivariate analysis. is study can increase awareness about the importance of measuring hemodialysis adequacy and giving the correct hemodialysis dose to achieve the intended benefit.

show abstract

Section: Discussionmentioning

confidence: 90%

Adequacy of Hemodialysis and Its Associated Factors among Patients Undergoing Chronic Hemodialysis in Dar es Salaam, Tanzania

Somji

Ruggajo

Moledina

2020

International Journal of Nephrology

View full text Add to dashboard Cite

show abstract

“…Although sufficient literature is available on measuring hemodialysis adequacy and the factors responsible for it but very few has compared the effect of dialyzer surface area on the adequacy of hemodialysis. Reference [8] had done a similar study in Bangladesh, however their study was restricted to measuring adequacy in single dialysis session by URR and single pool (Kt/V) while increasing surface area of dialyzers and they did not couple this to decreasing frequency of hemodialysis per week. Their results came significant (p value < 0.001) and they concluded that single session adequacy can be increased by increasing the surface area of dialyzers.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Increasing Surface Area of Dialyzer Membrane on Adequacy of Hemodialysis

et al. 2021

View full text Add to dashboard Cite

Introduction: The patients with end stage renal disease requires 12 hours of hemodialysis per week divided in three equal sessions (4 hours/day for 3 days/week). Some studies show that adequacy of hemodialysis can be maintained by increasing the surface area of the dialyzer membrane and decreasing the frequency of treatment which can help the poor socioeconomic status patients in getting effective hemodialysis at a low cost. Objectives: To observe whether by increasing the surface area of dialyzer the dose of dialysis can be reduced against the standard hemodialysis prescription. Study design: Randomized Control Trial. Study Duration: Six months from March 2017 to August 2017. Settings: Department of Nephrology, The Indus Hospital Karachi. Subjects: ESRD patients undergoing Hemodialysis for at least 6 months at The Indus Hospital Karachi. Methods: In this prospective randomized control study, a total of 60 patients of end stage renal disease receiving hemodialysis for more than six months were included and divided into 2 groups randomly (Arm-A: twice weekly dialysis using a larger surface area dialyzer and Arm-:B thrice weekly dialysis using regular surface area dialyzer). Results: A total of 59 (30 in Arm A and 29 in Arm B) patients were enrolled in the study out of which majority of the patients were male (59.3%). On average significantly higher URR and eKt/V were reported in Arm A whereas, higher mean standard (weekly) stdKt/V was reported in Arm-B. Conclusion: Standard protocols should be followed to maintain the adequacy of Hemodialysis.

show abstract

“…The passage of the uremic solutes via the membrane surface is strongly affected by differences in the inter-membrane diffusion rate, solubility of solutes, electrical charge density, and polarity on the surface of the intact membrane Technological advances in membrane chemical compositions; dialyzer design and sterilization techniques have led to improved performance of dialyzer and prolong survival time of ESRD patients. Currently, different types of dialyzers are commercially available in the market, and they can be classified in terms of membrane chemical composition, membrane surface area and membrane permeability to water or different blood proteins such as middle molecules (ß2-microglobulin) (Chowdhury et al, 2012;Daugirdas et al, 2012;Nissenson and Fine, 2016).…”

Section: Discussionmentioning

confidence: 99%

Advanced Materials for Polymeric Ultrafiltration Membranes Fabrication and Modification

Muhamad¹,

Nazri²,

Lau³

et al. 2018

Advanced Materials for Membrane Fabrication and Modification

View full text Add to dashboard Cite

This book contains information obtained from authentic and highly regarded sources. Reasonable efforts have been made to publish reliable data and information, but the author and publisher cannot assume responsibility for the validity of all materials or the consequences of their use. The authors and publishers have attempted to trace the copyright holders of all material reproduced in this publication and apologize to copyright holders if permission to publish in this form has not been obtained. If any copyright material has not been acknowledged please write and let us know so we may rectify in any future reprint.Except as permitted under U.S. Copyright Law, no part of this book may be reprinted, reproduced, transmitted, or utilized in any form by any electronic, mechanical, or other means, now known or hereafter invented, including photocopying, microfilming, and recording, or in any information storage or retrieval system, without written permission from the publishers.

show abstract

Effect Of Surface Area Of Dialyzer Membrane On The Adequacy Of Haemodialysis

Cited by 7 publications

References 5 publications

Adequacy of Hemodialysis and Its Associated Factors among Patients Undergoing Chronic Hemodialysis in Dar es Salaam, Tanzania

Adequacy of Hemodialysis and Its Associated Factors among Patients Undergoing Chronic Hemodialysis in Dar es Salaam, Tanzania

The Effect of Increasing Surface Area of Dialyzer Membrane on Adequacy of Hemodialysis

Advanced Materials for Polymeric Ultrafiltration Membranes Fabrication and Modification

Contact Info

Product

Resources

About