Effect of supplements during the cold season on the reproductive system in prepubertal Tibetan sheep ewes

Jing, Xiaoping; Peng, Quanhui; Hu, Rui; Wang, Hongze; Yu, Xiao‐Qiang; Degen, A. Allan; Zou, Huawei; Bao, Shanke; Zhao, Suonan; Wang, Zhisheng

doi:10.1111/asj.12762

Cited by 20 publications

(15 citation statements)

References 65 publications

(76 reference statements)

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“…What is more, low temperatures have bad effects on the reproductive system. For example, cold exposure can induce the polycystic ovary phenotype by activating the sympathetic nervous system and changing the development of ovarian follicle [8,10,31] and cause an increase in germ cell apoptosis and decrease mammalian reproductive capacity [1][2][3]. Reproductive hormone disorders also affect follicular development by regulating and activating ovarian sympathetic activity [5].…”

Section: Discussionmentioning

confidence: 99%

“…It also can affect follicular development by activating sympathetic activity in the ovary [3,4]. In addition, cold not only induces menstrual disorders and dysmenorrhea [5,6], it can also trigger ovarian insulin resistance, reproductive hormone disorders, and polycystic ovary phenotype [7][8][9]. Cold exposure can not only induce gynecological diseases via sympathetic neuroendocrine and endocrine systems, oxidative damage, and energy metabolism pathway [10][11][12][13], but it can also influence on reproductive system, through blood circulation changes.…”

Section: Introductionmentioning

confidence: 99%

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Effect of cold stress on ovarian & uterine microcirculation in rats and the role of endothelin system

Wang

Xiao

Fang

et al. 2020

Reprod Biol Endocrinol

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Background: Cold, an environmental factor, induces many reproductive diseases. It is known that endothelin (ET) is a potent vasoconstrictor, and cold stress can increase the expression of ET and its receptors. The cold stress rat model was developed to examine two parameters: (1) the effects of cold stress on ovarian and uterine morphology, function, and microvascular circulation and (2) possible mechanisms of ET and its receptors involved in cold stress-induced menstruation disorders. Methods: The rat cold stress model was prepared with an ice water bath. The estrous cycle was observed by methylene blue and hematoxylin and eosin (H&E) staining. Serum estradiol 2 (E 2), testosterone (T), progesterone (P) were detected by radioimmunoassay. Hemorheology indices were measured. The real-time blood flow of auricle and uterine surfaces was measured. Expressions of CD34 and α-SMA in ovarian and uterine tissues were detected by immunohistochemistry. ET-1 contents in serum were tested, and expressions of ET-receptor types A and B (ET-AR and ET-BR) in ovarian tissues were detected via Western blotting. Results: Cold stress extended the estrous cycle, thereby causing reproductive hormone disorder, imbalance of local endothelin/nitric oxide expression, and microcirculation disturbance. Cold-stress led to up-regulation of ET-AR expression and protein and down-regulation of ET-BR expression in rats. Conclusions: This study suggests that the reason for cold stress-induced dysfunction in reproductive organs may be closely related to the imbalance of ET-1 and its receptor expressions, leading to microvascular circulation disorders in local tissues.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of cold stress on ovarian & uterine microcirculation in rats and the role of endothelin system

Wang

Xiao

Fang

et al. 2020

Reprod Biol Endocrinol

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“…Despite differences in the consumption of mineral supplement in powder and in block (P=0.0385), there was no difference in performance and carcass characteristics of lambs (P>0.05), probably because diets were very similar in both treatments. Jing et al (2017) conducted a study with ram lambs on pasture with no supplementation and supplemented with mineral blocks or concentrate and reported a difference in weight gain between treatments, with the animals fed on salt block having an intermediate performance. Similar to this present study, Campbell et al (2017), assessed the difference between mineral salt in block and in powder in the diet of lambs and found no difference in weight gain in stall-feeding, nor in feed conversion or consumption of dry fodder.…”

Section: Experiments 2: Lambs In Finishing Phasementioning

confidence: 99%

Block of mineral salt in the diet of sheep and lambs and their effects on health and performance

2018

Aust. J. Basic & Appl. Sci.

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Sheep farming is growing worldwide (FAOSTAT, 2016), including in tropical areas, where production of dry forage is high; however, it has a lower content of nutrients in comparison with forage of temperate climates. Overcoming nutritional deficiency of animals fed tropical forages is a challenge, especially during dry seasons. The grazing method is used to maximize forage production and reduce feeding costs. However, due to the high nutritional needs of lambs in the growing stage, they can be stall-fed at finishing, as they are slaughtered young and have a greater nutritional need than ewes do. Supplements to grazing sheep are used to enhance animal performance, as well as to improve animal health (PEREIRA et al., 2017). Supplementation with minerals is critical to animal performance and health due to mineral deficiencies in the soil-plant system, which directly affect animal nutrition. Mineral deficiency negatively influences animal growth, reproduction, immune system, cellular replication, skeletal progress, and energetic metabolism (WANG et al., 2009; HAENLEIN; ANKE, 2011; OVERTON; YASUI, 2014). The mineral supplementation is traditionally offered as powder, which limits its adequate use due to its hygroscopic characteristics. Multi-nutritional block is an alternative for mineral supplementation for sheep production systems. The use of minerals in block influence positively parameters, such as feeding efficiency, milk production, reproductive performance (KIOUMARSI et al., 2011; WANG et al., 2016). The use of mineral blocks is easy and efficient, and sheep can receive the necessary requirements of oligoelements to ensure health and optimum productivity, with reports of various benefits for reproduction, reduction of mortality rate, greater economic return (WANG et al., 2016). We hypothesized if sheep and lambs have good intake of mineral salt in block and if its consumption is beneficial to their health, performance and skeletal quality. The objective of this study was to assess the effects of mineral supplementation in a block format salt on the consumption, performance, skeletal characteristics and hematological and biochemical parameters of sheep and lambs reared under tropical conditions. MATERIAL AND METHODS The experiment protocol for the present experiment was approved by the Animal Ethics and Well-being Committee of the University of São Paulo, No. 8755210515, issued on July 7, 2015. The study was divided into two experiments. The first experiment comprised pregnant sheep reared under the grazing system and the second with stall-finished lambs. Both were conducted in the Faculty of Animal Science and Food Engineering of the

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“…Additionally, earlier findings illustrated that supplementation during the cold season stimulates the hypothalamic-pituitary gonadal axis and enhances follicular development in prepubertal Tibetan sheep ewes on the Qinghai-Tibetan plateau [19]. Meanwhile, it has been reported that enhanced nutrition improves the reproductive efficiency of animals.…”

Section: Introductionmentioning

confidence: 99%

Effect of Concentrate Supplementation on the Expression Profile of miRNA in the Ovaries of Yak during Non-Breeding Season

Xie

Kalwar

Yan

et al. 2020

Animals

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Yak (Bos grunniens) is an important and remarkable livestock species that survives in the challenging environment of the Qinghai–Tibetan Plateau. However, its growth rate is slower and reproductive potential is generally lower than cattle. Meanwhile, it has been reported that enhanced nutrition improves the reproductive efficiency of animals. The purpose of this study was to investigate the effect of concentrate supplementation on the miRNA expression profile in the ovaries of yak during the non-breeding season. The study displayed that non-breeding season supplementation significantly improved growth performance, serum biochemical indicators, and reproductive hormone concentrations in yaks. In this study, we also examined the differential expression analysis of miRNA in the ovaries of yak during non-breeding seasons using Illumina Hiseq sequencing technology. As a result, 51 differentially expressed miRNAs were found in the experimental group (CS) and control group (CON). Gene Ontology (go) and Kyoto Genome Encyclopedia (KEGG) analysis of target genes showed that beta-alanine metabolism; tryptophan metabolism; sphingolipid metabolism; alanine, aspartate and glutamate metabolism; and the inositol phosphate metabolism pathway attracted our attention. Based on qRT-PCR, seven miRNAs were assessed to verify the accuracy of the library database. We predicted and identified potential miRNA target genes, including LEP, KLF7, VEGFA, GNAQ, GTAT6, and CCND2. miRNA and corresponding target genes may regulate yaks’ seasonal reproduction through their nutritional status. This study will provide an experimental basis for improving the reproductive efficiency of yaks by supplementation in the non-breeding season.

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Effect of supplements during the cold season on the reproductive system in prepubertal Tibetan sheep ewes

Cited by 20 publications

References 65 publications

Effect of cold stress on ovarian & uterine microcirculation in rats and the role of endothelin system

Effect of cold stress on ovarian & uterine microcirculation in rats and the role of endothelin system

Block of mineral salt in the diet of sheep and lambs and their effects on health and performance

Effect of Concentrate Supplementation on the Expression Profile of miRNA in the Ovaries of Yak during Non-Breeding Season

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