Effect of supplementation with methionine and different fat sources on the glutathione redox system of growing chickens

Németh, Kornél; Mézes, Miklós; Gaál, T.; Bartos, Andres E; Balogh, Krisztián; Húsvéth, Ferenc

doi:10.1556/avet.52.2004.3.12

Cited by 32 publications

(16 citation statements)

References 18 publications

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“…The increased GSH-Px activity was possibly caused by the higher substrate (GSH) content in the same group as was also found in our previous experiment (Németh et al, 2004).…”

Section: Discussionsupporting

confidence: 86%

Effect of combined treatment with aflatoxin B 1 and T-2 toxin and metabolites on some production traits and lipid peroxide status parameters of broiler chickens

Pál

Dublecz

Kovács-Weber

et al. 2009

Acta Veterinaria Hungarica

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Three groups of cockerels were fed with a control diet, with a diet contaminated with T-2 and HT-2 toxin (0.31 and 0.26 mg/kg) or with that containing a combination of T-2 and HT-2 toxin (0.32 and 0.25 mg/kg) and aflatoxin B 1 (AFB 1 , 0.38 mg/kg) for 21 days. Body weight gain and feed conversion ratio did not differ significantly among the groups. Malondialdehyde concentration of the liver was lower in the group fed the diet contaminated with the combination of T-2 + HT-2 toxin and aflatoxin B 1 as compared to the control group or the group fed T-2 + HT-2 toxins. Reduced glutathione (GSH) content of the liver was lower in the T-2 + HT-2 group than in the group fed a combination of T-2, HT-2 and aflatoxin. Reduced glutathione content of the heart was higher in the T-2 + HT-2 group than in the control group. Mycotoxin contamination had no effect on glutathione peroxidase (GSH-Px) activity in comparison to the control, but significantly lower GSH-Px activity was found in the heart of chickens in the T-2 + HT-2 + AFB 1 group than in the T-2 + HT-2 group. In this study, T-2 + HT-2 toxin and aflatoxin B 1 contamination of the diets did not affect the production traits adversely and did not exert additive effects on lipid peroxidation and on the glutathione redox system.

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“…The increased GSH-Px activity was possibly caused by the higher substrate (GSH) content in the same group as was also found in our previous experiment (Németh et al, 2004).…”

Section: Discussionsupporting

confidence: 86%

Effect of combined treatment with aflatoxin B 1 and T-2 toxin and metabolites on some production traits and lipid peroxide status parameters of broiler chickens

Pál

Dublecz

Kovács-Weber

et al. 2009

Acta Veterinaria Hungarica

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“…the actual supply of methionine and cysteine (Németh et al, 2004). The amino acid content of the diets was near the same in both groups which means that DDGS with higher proportion of PUFA, therefore higher susceptibility to oxidation, may provoke lipid peroxidation.…”

mentioning

confidence: 88%

Effects of Distillers Dried Grain with Soluble (DDGS) on Meat Quality, Lipid Peroxide and Some of Antioxidant Status Parameters of Fattening Turkey

et al. 2012

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A small-scale feeding trial was conducted with 30 BUT Big 6 male turkeys (15 in each group) fed diets containing 0% or 15% distillers dried grain with soluble (DDGS) to investigate the effects of DDGS on meat quality, including fatty acid composition, and lipid peroxide and glutathione status of blood and liver. Quality parameters of breast meat did not differ between the treatments groups, except significantly higher shear force in the group fed dietcontaining DDGS. DDGS inclusion did not cause significant changes in the chemical composition of breast muscle but revealed significantly lower proportion of myristic, palmitoleic and total saturated fatty acids, and higher proportion of linoleic and total polyunsaturated fatty acids. The higher proportion of polyunsaturated fatty acids of the diet containing 15% DDGS caused higher malondialdehyde content in blood plasma and red blood cell haemolysate, but not in liver or muscle homogenates. Consequently reduced glutathione content was significantly lower in blood plasma but higher in liver homogenate as effect of DDGS added to the diet, but did not differ in red blood cell haemolysate. Glutathione peroxidase activity showed similar changes as reduced glutathione. These results suggest that higher proportion of polyunsaturated fatty acids of the diet containing 15% DDGS resulted in higher malondialdehyde formation in blood, but not in liver and breast muscle because of the activation of the glutathione redox system in liver.

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“…25,37,47) Our results showed that hepatic GSH, which was measured after intoxication with acetaminophen, was significantly lower in soybean oil fed animals than counterpart of those groups (Fig. 1).…”

Section: Discussionmentioning

confidence: 64%

Diets with Beef Tallow Prevent Acute Acetaminophen Hepatotoxicity Compared to Diets with Soybean Oil in a Rat Model

Hwang

Kwak

Lim

et al. 2010

JOURNAL OF HEALTH SCIENCE

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Dietary polyunsaturated fatty acids (PUFA) increase liver injury in response to ethanol feeding. We tested the hypothesis that diets rich in linoleic acid (18:2 n-6) would also affect acute liver injury after acetaminophen injection. To determine whether the types and quantity of dietary fats were important, we examined the effects of feeding diets with either 7 or 15 g per 100 g soybean oil or beef tallow. After the feeding period, animals were unfed and injected either with 600 mg/kg body weight acetaminophen suspended in gum arabic-based vehicle, or with vehicle alone. Samples of plasma and liver were taken for analyses of liver-specific enzymes, [glutamatepyruvate transaminase (GPT) and glutamate-oxaloacetate transaminase (GOT)] and hepatic glutathione (GSH) and thiobarbituric reactive substances (TBARS) levels, respectively. Treatment with acetaminophen significantly elevated levels of plasma GOT and GPT as well as hepatic TBARS but reduced hepatic GSH levels in groups fed diets with soybean oil compared to beef tallow. The feeding regimens changed the ratio of 18:2 n-6 to oleic acid (18:1 n-9) in liver membrane phospholipid approximately 4-to 6-fold, and produced modest changes in arachidonic acid (20:4 n-6). We conclude that acetaminophen-induced hepatotoxicity can be protected with more saturated fatty acids (SFA)-rich diet but can be exacerbated with PUFA-rich diet by modulating the tissue fatty acid composition.

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Effect of supplementation with methionine and different fat sources on the glutathione redox system of growing chickens

Cited by 32 publications

References 18 publications

Effect of combined treatment with aflatoxin B 1 and T-2 toxin and metabolites on some production traits and lipid peroxide status parameters of broiler chickens

Effect of combined treatment with aflatoxin B 1 and T-2 toxin and metabolites on some production traits and lipid peroxide status parameters of broiler chickens

Effects of Distillers Dried Grain with Soluble (DDGS) on Meat Quality, Lipid Peroxide and Some of Antioxidant Status Parameters of Fattening Turkey

Diets with Beef Tallow Prevent Acute Acetaminophen Hepatotoxicity Compared to Diets with Soybean Oil in a Rat Model

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