Effect of Supplementation of Withania Coagulans Fruit on the Fasting Plasma Glucose Levels of Type 2 Diabetic Subjects

Hemalatha, .; Vigasini, Nora

doi:10.22159/ajpcr.2018.v11i12.27433

Cited by 3 publications

(1 citation statement)

References 4 publications

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“…The factory Shows colorful type of conditioningviz. hypoglycemic ( 4,14) hypolipidemic, Free Radical scavenging, cardiovascular, hepatoprotective, antiinflammatory, reduce Oxidative tress, crack mending, antitumor, Immuno-suppressive, cytotoxic, antifungal and antibacterial properties( 11)…”

Section: Introductionmentioning

confidence: 99%

The Phytochemical and Pharmacological Screening of Withania Coagulans

Sanskruti Pawar,

Shubhangi Manikpuriya,

Gajanan Sanap

2023

World J. Bio. Pharm. Health Sci.

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In ancient system of the drug, colorful shops shows to cure colorful health disordes and conditions. Withania coagulans Dunal, Is generally known as ‘ Indian bubbish maker ’ Or ‘ Vegetable Rennet ’ because The part of withaniai.E fruits and Leaves are used as a coagulant. Withania coagulans(Withania coagulans) dunal belongs To Family solanaceae.Withania coagulans dunal Is a argentine- whitish In colour, It's small under shrub It Is distributed In east of The mediterranean region. It Isone Of The most important medicinal factory and It's veritably useful In ayurveda. In ayurvedic system Of drug,Withania coagulans Is fxtensively Used In diabetic Cases, antimicrobial, antitumour and also shows other colorful exertion. Coagulin H Insulated FromWithania coagulans displayed effect On The vulnerable response. The Dried Flowers were uprooted consecutively by methanol and water. Withania coagulans Show remedial effect Of The Part of whole factory Withania coagulans dunal Is A Rigid, argentine- whitish Small Shrub, about 30- 150 Cm Altitudinous. The leaves are about2.5-7.5 Cm long and1.5 Cm broad. The Seeds Are Dark Brown, Observance Shaped, rough with sharp Fruity smell. dunal Flower may contain nioactive element to Treat colorful conditions. Withania coagulans is pharmacological Important remedial Factory, generally Known As Rishyagandha. It's used In treatment of colorful conditions like Indigestion, diabetes mellitus, liver diseases, sanctification Of blood and controls blood Pressure. In addition, It's reported To control tube glucose situations and precluding renal complications. A standard protocol was Followed For The birth Of Withania coagulans. The fruits of Withania coagulans 0.28 G/ 100 Ml) Were Soaked In distilled water overnight followed by a mechanical dissipation using A sterile cotton wood and filtration through rubbish cloth.

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Section: Introductionmentioning

confidence: 99%

The Phytochemical and Pharmacological Screening of Withania Coagulans

Sanskruti Pawar,

Shubhangi Manikpuriya,

Gajanan Sanap

2023

World J. Bio. Pharm. Health Sci.

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Withania coagulans Dunal.: A Narrative Review of an Anti-diabetic Shrub of the Desert Biome

Balkrishna,

Mishra,

Singh

et al. 2024

NPJ

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Diabetes mellitus is a chronic disease affecting more than 300 million people worldwide. Even after advances in medicine, we are still away from a permanent solution to this problem. Longterm use of currently available treatments are associated with adverse effects ranging from cardiovascular conditions, renal disorders, liver ailments, and weight gain. Subsequently, a significant diabetic population seeks herbal medicines that are said to control blood sugar levels. Several plants have been explored in this context; one such plant is Withania coagulans Dunal., which is known for the hypoglycemic property due to its fruits. Different plant parts and bioactive components like withanolides exhibited anti-diabetic activity in type 2 diabetes models in vivo and in vitro. However, clinical studies are limited and more research is warranted. Bioactive composition of W. coagulans include Withanolide J, F; Coagulin C, E, L; Ajugin E, Withaperuvin C and others. Bioavailability of Withaferin A from W. coagulans was enhanced by co-administration of Piperine. Herbal quality control and commercialization aspects are also highlighted. W. coagulans can be employed in managing type 2 diabetes mellitus after detailed follow-up studies.

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Effectiveness and Safety of Ayurvedic Medicines in Type 2 Diabetes Mellitus Management: A Systematic Review and Meta-Analysis

et al. 2022

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Introduction: Many Ayurvedic medicines have the potential for managing type 2 diabetes mellitus (T2DM), with previous systematic reviews demonstrating effectiveness and safety for specific Ayurvedic medicines. However, many of the reviews need updating and none provide a comprehensive summary of all the Ayurvedic medicines evaluated for managing T2DM.Objective: The objective of this systematic review was to evaluate and synthesize evidence on the effectiveness and safety of Ayurvedic medicines for managing T2DM.Inclusion criteria: Published and unpublished RCTs assessing the effectiveness and safety of Ayurvedic medicines for managing T2DM in adults.Methods: The JBI systematic review methodology was followed. A comprehensive search of sources (including 18 electronic databases) from inception to 16 January 2021 was made. No language restrictions were applied. Data synthesis was conducted using narrative synthesis and random effects meta-analyses, where appropriate. Pooled results are reported as mean differences (MD) with 95% confidence intervals (CI).Results: Out of 32,519 records identified from the searches, 219 articles were included in the systematic review representing 199 RCTs (21,191 participants) of 98 Ayurvedic medicines. Overall, in the studies reviewed the methodology was not adequately reported, resulting in poorer methodological quality scoring. Glycated hemoglobin (HbA1c) was reduced using Aegle marmelos (L.) Corrêa (MD -1.6%; 95% CI −3 to −0.3), Boswellia serrata Roxb. (−0.5; −0.7 to −0.4), Gynostemma pentaphyllum (Thunb.) Makino (−1; −1.5 to −0.6), Momordica charantia L. (−0.3; −0.4 to −0.1), Nigella sativa L. (−0.4; −0.6 to −0.1), Plantago ovata Forssk. (−0.9; −1.4 to −0.3), Tinospora cordifolia (Willd.) Hook.f. and Thomson (−0.5; −0.6 to −0.5), Trigonella foenum-graecum L. (−0.6; −0.9 to −0.4), and Urtica dioica L. (−1.3; −2.4 to −0.2) compared to control. Similarly, fasting blood glucose (FBG) was reduced by 4–56 mg/dl for a range of Ayurvedic medicines. Very few studies assessed health-related quality of life (HRQoL). Adverse events were not reported in many studies, and if reported, these were mostly none to mild and predominately related to the gastrointestinal tract.Conclusion: The current evidence suggests the benefit of a range of Ayurvedic medicines in improving glycemic control in T2DM patients. Given the limitations of the available evidence and to strengthen the evidence base, high-quality RCTs should be conducted and reported.

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Effect of Supplementation of Withania Coagulans Fruit on the Fasting Plasma Glucose Levels of Type 2 Diabetic Subjects

Cited by 3 publications

References 4 publications

The Phytochemical and Pharmacological Screening of Withania Coagulans

The Phytochemical and Pharmacological Screening of Withania Coagulans

Withania coagulans Dunal.: A Narrative Review of an Anti-diabetic Shrub of the Desert Biome

Effectiveness and Safety of Ayurvedic Medicines in Type 2 Diabetes Mellitus Management: A Systematic Review and Meta-Analysis

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